1, epirubicin is an isomer of adriamycin: epirubicin belongs to antibiotics. It is an isomer of adriamycin, and its mechanism of action is that it is directly embedded between DNA nucleobase pairs, which interferes with the transcription process and prevents the formation of mRNA, thus inhibiting the synthesis of DNA and RNA.
2. Different toxicity: Compared with adriamycin, the curative effect is equal to or slightly higher, but it is less toxic to the heart. Adriamycin is toxic to the heart, which can lead to heart failure in severe cases.
3. Different uses: Epirubicin is suitable for local chemotherapy such as hepatic artery intubation or intraperitoneal chemotherapy. Adriamycin is suitable for acute leukemia (lymphocytes and granulocytes), malignant lymphoma, breast cancer, bronchial lung cancer (undifferentiated small cells and non-small cells), ovarian cancer, soft tissue sarcoma, osteosarcoma, rhabdomyosarcoma, Ewing sarcoma, blastoma, neuroblastoma, bladder cancer, thyroid cancer, prostate cancer, head and neck squamous cell cancer, testicular cancer, gastric cancer, liver cancer and so on.
References:
Baidu Encyclopedia-Epirubicin
Baidu encyclopedia-adriamycin