This sentence may appear in different occasions, such as quarrels between friends, contradictions between lovers, and even in a wider context, such as conflicts between countries or cultures.
Therefore, understanding this sentence needs to take into account the specific situation and context. If lovers say "I don't want to lose you", it may be that one party loves the other deeply and doesn't want to end the relationship because of some contradictions; If it is between friends, it may be that friends cherish this friendship and don't want to lose it because of some misunderstandings or contradictions; If it is a conflict between countries or cultures, it may represent an attitude of reconciliation and tolerance, and do not want to lose contact with other countries and cultures.
Generally speaking, "I don't want to lose you" expresses a strong desire to maintain a relationship, and I don't want to lose important people or things because of some problems or difficulties.