Is the increase of creatinine level in gout patients necessarily abnormal renal function? There is no doubt that abnormal renal function will lead to an increase in serum creatinine level, especially when the damage exceeds 50%. Creatinine sometimes rises, not necessarily because of abnormal renal function. It is necessary to measure glomerular filtration rate to evaluate the kidney. The glomerular filtration rate is lower than 89mL, indicating that the kidney is slightly reduced. If gout patients suspect that renal function is impaired, besides serum creatinine level, glomerular filtration rate, urea nitrogen and its endogenous creatinine clearance rate need to be integrated, and some cases need to be diagnosed by renal B-ultrasound.
What is the reason for the increase of creatinine in gout patients? 1, age
Creatinine varies with age and sex. It is a physiological decrease in the kidneys of the elderly, and a slight increase in most blood creatinine is a routine situation.
2. Fitness exercise
Creatinine is a metabolic substance of muscles in the whole body. After doing excessive exercise or strength training in a short time, muscle fibers will cause a lot of creatine phosphate, and the creatinine level will increase during examination.
Step 3: Diet.
High animal protein diet can promote the increase of creatinine level, and the clearance rate of endogenous creatinine in kidney is limited. Excess creatinine can not be discharged into blood night, thus increasing the serum creatinine level.
4, kidney disease
Creatinine is completely excreted by glomerulus, and renal tubular injury cannot be catabolized. According to creatinine value, glomerular function can be evaluated. Suffering from gout attack, three highs, nephritis, chronic renal failure and its nephrotic syndrome will promote the increase of creatinine level.
5. Drug elements
Many drugs will cause kidney damage, resulting in drug-induced kidney damage, and promote a significant increase in serum creatinine levels. Taking benbromarone in gout patients can inhibit renal tubular injury, decompose and metabolize blood uric acid, and easily increase the concentration of blood uric acid in renal tubular injury. Without proper drug treatment, it is likely to increase serum creatinine.
How to reduce creatinine level? 1, antibiotics
If the immune function declines due to abnormal autoimmune system, such as proteinuria caused by repeated feelings, and the kidney is easily damaged, anti-infective drugs can be used for treatment at this time. Under the guidance of a doctor, antibiotics should be used in a certain amount of foot treatment, and drugs that are toxic to the kidneys should not be used.
2. Inject normal saline or glucose water.
Insufficient renal blood volume easily leads to endotoxin extraction and rapid increase of creatinine level. At this time, transfusion should be used to alleviate the problem of insufficient oxygen and water in the kidney, accelerate the fluidity of venous blood in the kidney, promote endotoxin metabolism and help reduce creatinine.
3, growth hormone or immune preparation
Uric acid nephropathy and calculus can easily lead to proteinuria leakage, resulting in moderate and severe immune inflammation of the kidney. When the serum creatinine reaches 200 micromoles, immunotherapy should be given. Under the specific guidance of doctors, immune agents or cyclosporine can inhibit renal inflammation and help reduce proteinuria.