Hyaluronic acid (HA) is one of the important components of human matrix, which is mainly metabolized in the liver. At present, HA has been considered as one of the most sensitive and reliable indicators to reflect the degree of liver disease and liver fibrosis. Clinical significance: The serum HA of most patients with liver disease is increased, and it is increased with the aggravation of liver disease, and the liver cirrhosis is significantly higher than that of non-liver cirrhosis. Serum HA level is a good serological index to judge the severity of liver disease, distinguish whether there is cirrhosis and predict its development trend. Among the indexes reflecting liver fibrosis during the transformation from chronic liver disease to cirrhosis, HA has the best diagnostic value, followed by PCIII and LN. The serum HA of patients with liver cancer is obviously increased, and it is reported that the HA level in body fluids or tissues of patients with malignant tumor is increased. Therefore, HA can be used as an auxiliary index to differentiate benign and malignant lesions. HA in patients with nephrotic syndrome and glomerulonephritis was significantly increased, and HA in patients with chronic nephritis and chronic renal failure was significantly higher than that in normal control group. The level of HA is directly proportional to the degree of renal damage. Observing the changes of hyaluronic acid in serum and bone marrow fluid is of great significance to distinguish benign and malignant hematological diseases, judge the pathogenicity of acute leukemia and estimate the prognosis. Patients with connective tissue disease (CTD) have significantly increased HA. The determination of hyaluronic acid in cerebrospinal fluid is helpful for the differential diagnosis of meningitis. The concentration from high to low is cerebral cysticercosis, diseased brain, encephalomyelitis and encephalomyelitis. There is a significant difference between encephalomyelitis and diseased brain, and there is also a significant difference between encephalomyelitis and diseased brain, but there is no significant difference between them. HA concentration in cerebrospinal fluid was positively correlated with the number of nucleated cells, protein and lactic acid concentration, and negatively correlated with sugar and chloride. Note: serum, pleural effusion and cerebrospinal fluid can be used for specimens, and they can be stored at 2 ~ 8℃ for 48 hours. -20℃ can be stored for a long time. Reference value: 2 ~ 1 10 ng/ml. Therefore, your condition needs further liver function examination, and obviously you can't get a health certificate.