Through the investigation and statistics of the growth performance, production performance, mortality and other clinical indicators of immunized and non-immunized animals, the immune effect of the vaccine was evaluated by statistical analysis and comparison. The commonly used evaluation indexes of immune effect are effect index and protection rate. The same method can be used to evaluate the protective effect of different types of vaccines on a disease, and the same vaccine from different manufacturers or different immunization procedures of the same vaccine.
1. Generally, the immune effect of the vaccine is evaluated by measuring the geometric average titer of serum antibodies of immunized animals and comparing the amplitude and duration of titer increase before and after vaccination. For example, the immune effect evaluation of Newcastle disease and avian influenza vaccine showed that the antibody titer was more than 4 times higher than that before immunization after 14 days, indicating that the immune effect was good; If it is less than 4 times, it is considered that the immune effect is not good or it needs to be vaccinated again.
2. For the animals in the immune protection period, the antibody test is carried out every month, and the antibody titer of the animals in the immune protection period is above the protection line, indicating that the immune effect is good. For example, four months after Newcastle disease vaccine immunization, 70% of the animals' serum antibody titers reached more than 26, which means that the immunization effect is good.
Extended data:
First, experimental research, explain the difference between experimental research and non-experimental research in detail:
1. Observation study: a non-randomized study that observes and records the characteristics of the research object in the natural state, and describes and compares the results.
2. Experimental research: it is an analytical research that artificially intervenes and collects results.
3. Experimental research is artificial research, and observation research is natural research.
4. Expansion: the basic elements of observation and research: one is the research object, and the other is the research factor. In descriptive research, the research factor is the influencing factor; In analytical research, research factors are called risk factors or exposure factors.
5. Summary of characteristics of observational study: In the study, the observed objects can be grouped according to certain characteristics, and no experimental factors (intervention factors) are imposed, but random grouping is not needed.
6. Experimental research is to systematically manipulate the change of one variable under controlled conditions to study the influence of the change of this variable on other variables.
Second, the characteristics of various studies:
1, aiming at understanding phenomena and discovering and opening up new knowledge fields. Through experimental analysis or theoretical research, analyze the physical properties, structure and relationship of things, deepen the understanding of objective things, explain the essence of phenomena, reveal the laws of material movement, or put forward and verify various ideas, theories or laws.
2. There is no specific application or purpose. When conducting research, I can't see the results, I can't tell what it is useful, or although it will definitely be useful, I don't know the technical ways and methods to achieve the application purpose. Generally borne by scientists, they have great freedom in determining research topics and arranging work.
3. Research results usually have universal or universal correctness, and the results often show universal principles, theories or laws and are published in scientific journals or exchanged at academic conferences in the form of papers.
4. Therefore, when the purpose of research is to fully understand phenomena in the broadest sense, and/or when its purpose is to discover new fields of scientific research, no matter its direct application, it is regarded as basic research. Basic research can be divided into pure basic research and directional basic research.
5. The difference between pure basic research and directional basic research is that pure basic research is to promote the development of knowledge, regardless of long-term economic or social benefits, and is not committed to applying its results to practical problems or transferring them to departments responsible for application.
6. The purpose of directional basic research is to produce a wide knowledge base and provide information for solving the current, future or possible problems that have been seen or predicted.