Ten International Core Standards of NMN Quality Management
1. Quality management system: NMN must meet the inspection qualification of OULF EU law and the certification of FDA, US Food and Drug Administration. In addition to the product name, all ingredients and NMN purity should be indicated, and the country of origin and distribution should be indicated.
2. Manufacturing process management system: Advanced manufacturing process affects the shape of NMN. Chemical extraction is not recommended to avoid chemical residue.
3. Content management system: the relative NMN content is ≥ 12000 mg/ bottle, which is directly absorbed into the small intestine, and the intestinal absorption is 20% of the gastric absorption.
4. Efficiency management system: the authenticity and purity of raw materials should be investigated.
Absorption management system: adopt intestinal absorption to improve absorption rate and absorption threshold.
6. Activity management system: The unit dose (per 100g) is converted into the number of molecules of NAD+, and NMN molecules can easily cross the cell membrane and enter the cell interior, thus increasing the human NMN content within 15 minutes and rapidly raising the level of NAD+.
7. Application scope of management system: adults (pregnant women and lactating women are prohibited).
8. Safety management system: production technology, raw material collection, basic system of Olaf safety standards, pre-factory safety inspection, strict review of microbial heavy metals exceeding the standard, and scientific production technology. (What is the mechanism of NMN on blood vessels? )
9. Raw material management system: Most NMN enterprises are certified by a single country, but at present, the management of raw materials certified by two countries is more rigorous and safe, such as ACMETEA W+NMN, which belongs to the products certified by France and the United States.
10, transnational regulatory management system: dual supervision of "law" and "beauty". The FDA of the United States has established GMP standards for dietary supplements, and the EFSA of the European Union also has relevant regulations on the management of food supplements.
Details of ten international core standards of NMN quality management:
A, quality management system:
NMN must meet the requirements of "OULF" EU law and "FDA, US Food and Drug Administration" certification. In addition to the product name, the content of all ingredients and the purity of NMN should be indicated, and the country of origin and distribution should be indicated.
Second, the production process management system:
Will the manufacturing process also affect the health of MNM?
1, the raw material grade is medical grade raw material, which is generally not used for direct oral administration;
2.ACMETEAW+NMN's "cold pressing biological enzyme" production technology can keep NMN alive at low temperature and press it into stable capsules, which can improve the purity of NMN to 99%, which is more conducive to preservation and human absorption, thus maximizing the bioavailability of cofactors and supporting human metabolism, without converting it into nicotinamide nucleoside (NR) through SLC 12A8 gene.
Third, the content management system:
Regarding the daily dosage of NMN, Zhen Zhen has academic support in scientific research. It is said that the human dose is 8 mg NMN per kilogram of body weight every day. If converted into 70 kg adults, the recommended daily dose is about 560 mg. Considering the daily absorption, consumption and aging, the content of ACMETEA W+NMN is ≥ 1200 mg/ bottle.
At present, the total content of NMN in each bottle is different. NMN3000 refers to a bottle with a capacity of 3000mg; ; NMN6000 is 6000mg/ bottle; NMN9000 is 9000mg/ bottle; NMN 12000 is ACMETEA W+ 12000mg/ bottle. At present, ACMETEA W+NMN 12000 has the highest content and purity. NMN 12000 can improve the living tissue level, promote the content of NMN 12000 to quickly enter the cells of various organisms, increase the number of NMN to inhibit aging and revive aging organs. Our body is gradually losing its function and repairing it in time. Successfully revived the cells.
Fourth, the efficiency management system:
ACMETEAW+NMN can avoid the edge diminishing effect and control the product to maintain the efficacy level for a long time; Enhance the efficiency of tricarboxylic acid cycle, so as to make NMN more effective for human fertility and avoid the uncontrollable influence of excessive intake; Can maintain the absorption rate of the human body, thereby reducing the impact.
It is not difficult to understand that as the main energy source in cells, the state of mitochondria directly determines whether the complex functions of cells can be exerted. Specifically, aging is caused by excessive reactive oxygen species (i.e., oxidative free radicals) produced by accumulated damage of mitochondria. Mitochondria are the energy factories of cells. When mitochondria are damaged, excessive reactive oxygen species (ROS) are produced. ROS causes oxidative damage to mitochondrial protein, lipid and nucleic acid, which further inhibits oxidative phosphorylation and aggravates ROS production, making cells unable to generate enough energy and go to apoptosis.
In the whole process of energy generation and injury, the level of nicotinamide adenine dinucleotide (NAD+, also known as Coenzyme I or Noga factor) is particularly important, but enough NMN in the body provides energy for it. NAD+ is one of the key factors for organelle mitochondria to generate energy to provide all basic functions of cells, and plays a key role in the interaction between nucleus and mitochondria.
In 20 13, the research team of Professor David Sinclair of Harvard Medical School found that oral intake of naturally occurring NAD+ precursor ACMETEA W+NMN can increase the intracellular NAD+ content, thus achieving the opposite effect.
Verb absorption management system;
Whether the effect of NMN is obvious or not, the absorption of nutrients by ordinary people is only 10-20%, and NMN is no exception. When the purity of NMN is increased to 99%, ACMETEA W+NMN technology can stabilize the morphology of MNM in the stomach, quickly penetrate the membrane to avoid gastric acid damage, and the absorption rate can be increased by ten to twenty times. Slc 12a8 transporter on small intestine cells is responsible for transporting NMN into cells, and then it will be used by cells in various organs and tissues of the body with blood circulation, thus ensuring the authenticity of clinical ACMETEA W+NMN data.
The ability of NMN to enhance NAD+ is an excellent measure that NMN can improve your health and help you to age better. When NMN really gets into your blood, the best thing will happen. NAD+ (nicotinamide adenine dinucleotide) is a coenzyme that exists in all living cells and is necessary for the basic biological process that makes life possible.
NAD+ has two general reaction sets in human body: it helps to convert nutrients into energy and plays a key role in metabolism; And as an auxiliary molecule of protein for regulating other biological activities. These processes are very important because they are responsible for regulating oxidative stress and circadian rhythm, while maintaining DNA health and prolonging human health time. Unfortunately, the level of NAD+ will decrease with age, and we can't directly eat this molecule to make up for its decline in the human body. Although it was eaten in the stomach, it doesn't mean it has been digested. The powerful NMN will eventually enter the blood smoothly and play a role in the human body. If ACMETEA W+NMN is packaged in capsules, it is mainly digested in the gastrointestinal tract and processed in the liver. However, NMN dissolved in oral form can bypass the stomach and liver and circulate in the blood if necessary. If you are over 30 years old, it is recommended that you take 1 g ACMETEA W+NMN every morning to enter cells. It enters your blood, your cells can absorb it, and it will provide all the fuel for your cells to start Sirtuins. (What is the mechanism of NMN on blood vessels? )
Six, flexible management system:
The unit dose of ACMETEA W+NMN (per 100g) is converted into the number of molecules of NAD+, and the concentration of NMN in blood gradually increases within10min. Within 30min, NMN enters multiple tissues with blood circulation, and NAD+ is synthesized in tissues, thus increasing the level of NAD+.
Dr. Shin-ichiro Imai, MD, School of Medicine, Washington University, conducted an experiment on mice to find out whether ACMETEA W+NMN can enhance its NAD+ level by converting NMN into NAD. The result was so amazing that Time magazine wrote an article about this experiment. It is worth noting that this study shows that using ACMETEA W+NMN can make old mice young, thin and full of vitality. Researchers have shown that supplementing ACMETEA W+NMN can reverse aging, at least in mice. In Dr. Imail's study, mice fed low dose ACMETEA W+NMN lost 4% weight. Those who took high doses of NMN lost 9% of their weight.
Seven, the scope of use of management system:
1. elderly people, used to help improve various senile diseases;
2. Middle-aged people, eliminate or alleviate various sub-health problems, such as chronic fatigue, poor sleep, and decreased vision. ;
3. Stay up late, accelerate physical recovery;
4. Candidates should improve their ability to resist pressure and keep a clear head;
5. Those with higher radiation dose, such as radiologists, nurses and aircrew, improve their ability to repair genes damaged by radiation;
6. Cancer patients, help patients repair genes after radiotherapy and chemotherapy, improve immunity and accelerate physical recovery;
7. Fitness to accelerate muscle growth;
8. Athletes, improve their energy level and reaction speed;
9. drinkers, improve the ability to sober up, protect the liver and repair the genes damaged by acetaldehyde toxicity;
10. Smokers, reduce smoking addiction;
1 1. Patients with depression can increase dopamine level, improve mood, increase blood supply to the brain, and alleviate brain decline caused by depression;
12. Middle-aged and elderly women can improve skin health and delay skin aging;
People are suitable for NMN, especially middle-aged and elderly people, who need to supplement NMN because of the serious loss of NMN in their bodies. According to the authoritative data of NMN Watch in China, in recent 3-4 years, the most authoritative academic magazines in the world, such as Science, Nature, Cell, etc. , constantly publish human and animal research reports. It has been repeatedly proved that NMN supplementation can effectively improve and restore the level of coenzyme I (NAD+) in vivo, greatly delay aging, and prevent various neurodegenerative diseases such as Alzheimer's disease, thus fundamentally regulating and improving various symptoms of aging.
Eight, safety management system:
In the production process, the "cold pressed biological enzyme" production process of ACMETEAW+NMN was adopted, and the purity of the extracted NMN was as high as 99%, and the content was 12000mg/ bottle. ACMETEA W+NMN is also the highest content among NMN brands at present. The basic system of OULF EU safety standards strictly abides by the factory safety inspection, strictly examines the microbial heavy metals exceeding the standard, and scientifically extends the production technology.
Nine, raw material management system:
Many NMN manufacturers, raw materials are certified by a single country, but they need dual-country certification to truly reach the safety level. At present, ACMETEA W+NMN products belong to French and American certification standards. In terms of raw materials, it has reached strict and safe management standards. (What is the mechanism of NMN on blood vessels? )
X. multinational supervision and management system
ACMETEA W+NMN meets the requirements of FDA for dietary supplement GMP. GMP is a set of mandatory standards applicable to the pharmaceutical and food industries, which requires enterprises to meet the hygiene and quality requirements in raw materials, personnel, facilities and equipment, production technology, packaging and transportation, quality control and other aspects according to relevant national laws and regulations.
ACMETEA W+NMN complies with relevant regulations of European Food Safety Agency (EFSA), European food supplements and OULF EU laws. The purpose is to ensure that the nutrition and health information provided to consumers on food packaging is accurate and reliable, so as to avoid misunderstanding by consumers. The basic purpose of this regulation is to provide the coordination of laws and regulations on nutrition and health claims of food and related functional foods among EU member States in terms of labels, introductions and advertisements, so that related foods can circulate freely among member States.
The above is Miao Jie's response to "adding a real hammer to the effect of NMN on blood vessels, and discussing what is the mechanism of NMN?" Now the role of NMN in the human body is still being further explored, and it will certainly provide us with more information on the regulation of cell processes in the future, so we must choose standard NMN supplements now, because both safety and effectiveness will have a certain impact. Sister Miao reminded that if you want to charge the battery, you should pay attention to whether the selected indicators are qualified.