Chinese name: category of elixir of life: drug source: Han Feizi's work in Shanglin: historical story of Qin Shihuang Ying Zheng and alchemist Xu Fu, related works, scientific experiment, experimental process, experimental principle, application prospect, related legends and historical story. In 2 19 BC, Qin Shihuang sailed around Shandong Peninsula and stayed here for three months. There are three immortals living on three fairy mountains, holding elixir of life in their hands. The person who told this magical story to Qin Shihuang was the local alchemist Xu Fu. It is said that he has seen these three fairy mountains with his own eyes. Qin Shihuang was very happy after hearing this, so he sent Xu Fu to lead thousands of boys and girls to the sea to find the elixir of life. The mighty fleet led by Xu Fu set out, but he drifted at sea for a long time and didn't find what he called the fairy mountain, nor did he find the elixir. Qin Shihuang was a tyrant, and Xu Fu didn't finish the task. When he returned, he would be beheaded in the style of Qin Shihuang, so he drifted to Japan with these thousands of boys and girls. Although the blessing is gone forever, Qin Shihuang did not die seeking immortality. Four years later, in 2 15 BC, Qin Shihuang found another Yan man named Lu Sheng, who was a alchemist specializing in cultivating immortals. This time, Qin Shihuang sent Lu Sheng to the sea to seek immortality, which was different from Chuifu. Chuifu is looking for an elixir of life. This time, Lu Sheng went to the sea to find two ancient immortals, one named "Gao Shi". According to records, the "elixir of life" that Qin Shihuang couldn't find anywhere was commonly known as "Tai Sui" and the scientific name was "Meat Ganoderma lucidum". But in the end, Qin Shihuang did not take the elixir of life, nor did he live to be a hundred years old. Even the Qin Dynasty died long ago. Related works TV series Myth The movie Myth starring Hugh Bai Bing is Jackie Chan. Kim Hee Seon starred in the film "Love of Qin Fighters in Ancient and Modern Wars" (1989 version). Zhang Yimou plays Meng Gong Li/Zhu Lili TV series "Qin Warrior's Love in Ancient and Modern Times" (20 10). Du Chun plays Meng (the second part plays Blue Sky and the third part plays Luo Kaiping). Han Donger played by Ann (2) Scientific experiments in the TV series Legend of the Sword starring Yifeng Li and Qiao Zhenyu. It is reported that American scientists have successfully reversed the aging process for the first time through mouse experiments recently, paving the way for the development of drugs that "keep young forever". Ronald Debinho, an oncologist at Harvard University in the United States, was in charge of this research, and related scientific research results were published in the authoritative academic journal Nature. Before the experiment, the skin, brain and internal organs of these animals were similar to those of an 80-year-old man. Only two months after injecting them with drugs that can turn on a key enzyme, these animals have grown a large number of new cells, which are almost completely renewed and rejuvenated. What is even more surprising is that male rats can make female rats pregnant again and raise a large number of offspring. The major breakthrough of this experimental principle mainly focuses on telomere structure. These are miniature biological clocks that cover the ends of chromosomes to prevent chromosome damage. As time goes by, telomeres become shorter and shorter, which increases the risk of senile diseases such as Alzheimer's disease. When they become too short, the whole cell will die. Telomerase reverse transcriptase can reconstruct telomeres, but the body often turns off this enzyme. Debinho made mice age ahead of time by special methods, simulated the aging process of human beings, and then successfully revived telomerase reverse transcriptase by drugs. Application Prospect If with the help of this research, scientists develop drugs that can "keep young forever", people will live longer and healthier, will not be bothered by Alzheimer's disease and heart disease, and their skin and hair will be as bright as when they were young. This drug may also enable men and women to have children naturally until they are old. Increasing the time of healthy living can also greatly reduce the cost of health services and reduce the burden of family members to take care of sick relatives. Debinho said: "It's like a 40-year-old man looks like an 80-year-old man, and after the reversal, he reaches the level of 50 years old. By 2025, the number of elderly people over 60 will reach 65.438+0.2 billion, and people of this age group are prone to cancer, Alzheimer's disease and cardiovascular diseases. We are about to face a heavy social burden. This experiment is the first time that we have successfully reversed the aging process. This shows that there is a key point in reversing aging organs that we have never realized before. " He hopes that this technology can stop or slow down the aging process, and it is surprising to find and reverse this process. He believes that a drug that can produce the same effect on human beings should eventually be developed. Take middle-aged people as an example, this drug can delay or prevent them from developing Alzheimer's disease, heart disease and diabetes, and even prolong their life. However, people should also pay attention to the fact that a high level of telomerase reverse transcriptase will accelerate tumor growth, and it is impossible to eliminate all aging problems by one drug alone. Debinho said: "Aging is caused by many mechanisms. Therefore, although we think telomeres are very important, there are other factors that also play an important role. " Dr Steven Yatandi, a telomere expert at Harvard University, called the study "very beautiful", but he warned that an anti-aging drug can only reverse 10 years at most. Legend has it that there is a mysterious herb that can be refined and can only be found in the deep rift valley. After refining, this herb can be made into an elixir of life, also known as Resurrection Pill. So far, no one has said that he has seen this herb, because no one knows what it looks like (only one person has been to the depths of the rift valley and seen this herb, saying that it is a magical grass, although he has never seen it. )