Rats were given oral LD50:1650mg/kg; Inhale LC50:2 1000ppm /3H. Mice inhaled LCLO:24000/m3 /2H. Low toxicity. This product can irritate skin and mucous membrane. High concentration has anesthetic effect, and the anesthetic concentration is similar to the lethal concentration. High dose fashion has hepatotoxicity. When rats inhaled 590 mg/m3 for 3 hours, eyelids and nasal mucosa turned red. 147750/m3, corneal edema and turbidity, lingering, runny nose and nosebleeds. Rats, guinea pigs, rabbits and cats were exposed to the concentration of 50mg/L for 3 hours, and some animals fell sideways. 100mg/L appeared deep anesthesia, and some animals died after exposure to 1~4.5 hours. Anesthesia occurs within 1 hour at 200mg/L, and long-term use can lead to death. Inhalation concentration of rats >: 14000mg/m3, sleep, rigidity, deep coma, convulsion, epileptic brain waves. Animals can tolerate anesthesia after repeated inhalation. When animals are exposed to high doses for one or more times, liver fat infiltration and cell lysis will occur. Oral administration may cause gastric bleeding and ulcers. Direct application of 20% aqueous solution to rabbit skin can cause moderate skin irritation. 50% aqueous solution can cause serious corrosion damage, and 20% aqueous solution can cause serious keratitis in rabbit eyes. When THF comes into contact with air, it will form explosive peroxide, which can increase the irritation of THF. It is reported abroad that the anesthetic concentration is 73,800 mg/m3, and the olfactory threshold of human is 88.5mg/m3.
Toxic substance data: 109-99-9 (hazardous substance data)
health hazard
Symptoms such as dizziness, headache, chest tightness, chest pain, cough, fatigue, stomach pain, dry mouth, nausea and vomiting may occur after high concentration inhalation, and may be accompanied by eye irritation symptoms. Some patients may have liver dysfunction. The concentration of THF in urine is related to the concentration of THF in the environment, which can also lead to nosebleeds, leading to gastric bleeding and ulcers. High dose or repeated exposure can lead to fat infiltration and cell lysis in the liver. Direct action of 20% aqueous solution on human skin can cause moderate skin irritation, and 50% aqueous solution can cause serious corrosion damage. 20% aqueous solution used in human eyes will cause serious corneal damage: long-term contact will lead to the loss of sexual function and fertility, or kidney disease!
Precautions for use
Respiratory protection: When you may come into contact with its vapor, you should wear a filter gas mask (half mask). When necessary, it is recommended to wear self-contained breathing apparatus.
Eye protection: Generally, special protection is not needed, and safety glasses can be worn when exposed to high concentration.
Physical protection: wear anti-static work clothes.
Hand protection: wear benzene-proof and oil-proof gloves.
Others: Smoking is strictly prohibited in the workplace. After work, take a shower and change clothes. Pay attention to personal hygiene.
Skin contact: take off contaminated clothes and rinse skin thoroughly with soapy water and clean water.
Eye contact: Lift eyelids and rinse with running water or normal saline. See a doctor.
Inhalation: leave the scene quickly and go to a place with fresh air. Keep the respiratory tract unobstructed. If you have difficulty breathing, give oxygen. If breathing stops, give artificial respiration immediately. See a doctor.
Ingestion: Drink plenty of warm water, induce vomiting and seek medical advice.
Fire extinguishing method: spray water to cool the container, and if possible, move the container from the fire to an open place. If the container in the fire changes color or the safety pressure relief device sounds, it must be evacuated immediately.
Extinguishing agent: foam, dry powder, carbon dioxide, sand. Fire extinguishing with water is ineffective.
Small amount of leakage: adsorbed or absorbed by sand or other nonflammable substances. It can also be washed with plenty of water, diluted and put into the wastewater system.
A large number of leaks: damming or digging holes to contain them. Cover with foam to reduce steam disaster. Spray water to cool and dilute steam, protect field personnel, and dilute the leakage into nonflammable substances. Use explosion-proof pump to transfer it to tank car or special collector, and recycle it or transport it to waste disposal site for treatment.
Precautions for operation: closed operation and comprehensive ventilation. Operators must be specially trained and strictly abide by the operating procedures. Operators are advised to wear filter gas masks (half masks), safety glasses, anti-static work clothes and rubber oil-resistant gloves. Stay away from kindling and heat sources, and smoking is strictly prohibited in the workplace. Use explosion-proof ventilation system and equipment. Prevent the steam in the workplace from leaking into the air. Avoid contact with oxidants, acids and bases. When filling, the flow rate should be controlled, and grounding devices should be provided to prevent static electricity accumulation. When handling, handle with care to prevent the packaging and containers from being damaged. Equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment. Empty containers may leave harmful substances behind.
Precautions for storage: polymerization inhibitor is usually added to the goods. Store in a cool and ventilated warehouse. Stay away from fire and heat sources. The reservoir temperature should not exceed 30℃. The package should be sealed and not in contact with air. Should be stored separately from oxidant, acid, alkali, etc. , and should not be mixed. Adopt explosion-proof lighting and ventilation facilities. It is forbidden to use mechanical equipment and tools that are easy to generate sparks. The storage area should be equipped with emergency response equipment for leakage and suitable accommodation materials.
Occupational standard: TWA 590 mg/m3; STEL 640 mg/m3
References:
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