2. How can normal gastric mucosa protect itself from gastric acid and pepsin?

Protection is achieved through five levels: mucus -HCO3- barrier, epithelial barrier, gastric mucosal blood flow, immune cell-inflammatory response and repair and reconstruction factors.

1, mucus -HCO3- barrier: it has lubrication and mechanical protection, antibacterial and anti-H+ dispersion.

2. Epithelial barrier: Gastric epithelial cells are closely connected and can resist high concentration of acid and potential harmful substances.

3. Gastric mucosal blood flow: transport oxygen and nutrients, maintain the structural function and renewal of gastric mucosa, and promote mucus production and secretion.

4. Inflammatory reaction of immune cells: It has defensive and destructive effects.

5. Repair and reconstruction factor: it mainly plays the role of repairing after injury.

Extended data:

Gastric mucosa is a natural barrier to protect the safety of gastric wall. Under physiological conditions, the gastric mucosa is constantly attacked by physical and chemical factors, including gastric acid, Helicobacter pylori, drugs, reflux bile acid, irritating food and other factors will cause harm to the gastric mucosa. When there are too many aggressive factors, the gastric mucosa will be obviously damaged, which will cause stomach pain.

To repair gastric mucosa, attention and prevention should be strengthened from daily life, diet and other aspects.

In daily life, avoid cold food stimulation, stay away from spicy food stimulation, avoid indigestible food, avoid alcohol and tobacco stimulation, eat more sterilization and anti-inflammatory food such as garlic, and try to avoid drinking, spicy food, strong tea and coffee. And fundamentally eliminate gastric mucosal damage.

At the same time, pay attention to daily hygiene habits, pay attention to oral hygiene, often eat some foods that nourish the stomach, take a proper walk after meals, promote the digestion of the stomach, avoid eating foods that irritate the stomach, protect the health of gastric mucosa and prevent bad breath.

Baidu encyclopedia-gastric mucosa

Baidu encyclopedia-pepsin

People's Daily Online-Most stomachaches are caused by gastric mucosal damage. Expert: Stomach pain needs timely treatment.