Skin freezing, also referred to as liquid nitrogen cryotherapy, refers to a recent new technology in the field of therapeutics that kills viruses through extremely rapid freezing, and people with severe cold urticaria cannot be treated with this method. Liquid nitrogen cryotherapy is a combined effect of cryobiology. Normal cells are irreversibly damaged in a state of extreme freezing. It is the rapid killing of the cells in the diseased area through the state of extreme freezing that allows the area to recover normally. It is generally used to treat wart, corns, warts, neurodermatitis, and skin diseases.