But in the 1990s, PRP extraction technology needed to be made in a large laboratory, requiring more complex equipment, and also had problems such as insufficient concentration of growth factors, long production cycle, easy contamination, and risk of infection. With the continuous development of science and technology to date, there are a variety of technologies in the world that can quickly produce safe PRP plasma, and the scope of application is becoming more and more extensive.
Among them, in early 2004, two globally renowned professors of medical plastic surgery: Dr. Kubota (Japanese) and Prof. Otto (British), both working in London, innovated on the basis of PRP extraction technology to produce ACR plasma enriched with a high concentration of growth factors - which is rich in EGF that is not contained in other production methods. The production of ACR Plasma is a true application of PRP in injectable cosmetic technology, providing comprehensive conditioning and regeneration of the entire skin layer. At present, the innovative ACR technology based on PRP extraction technology has been widely used clinically in Europe, North America, South Africa, the Middle East, Australia, Japan, Singapore and other developed countries and regions.