Collagen has support, repair, moisturizing and whitening effects, and has a wide range of application prospects in the field of medical aesthetics and cosmetics. In the field of medical aesthetics, collagen can be used as fillers, facial rejuvenation, and dressings. In the field of cosmetics: anti-aging, whitening, moisturizing. Currently, the extraction method and genetic engineering method head collagen companies generally dressings and cosmetics to provide profits and cash flow, research and development of medical beauty and medical products layout of the future, medical - medical beauty - cosmetics - food and beverage and other multi-scene, multi-functional product matrix is **** the same direction.
Collagen is a structural protein in the extracellular matrix, containing one or more regions of triple-helical structure consisting of α-chains.
Collagen makes up 25-30% of the total body protein, weighs about 6% of body weight, and is widely distributed in skin, tendons, ligaments, and bones. There are 27 known types of collagen, the most common being types I to V. Type I is mainly found in tendons, bones and teeth, type II in cartilage and vitreous body, and type III in infant skin, cardiovascular and dermis. Collagen preparation methods mainly include animal source extraction and genetic engineering, the two methods have their own advantages and disadvantages, are making progress; in March and April 2021, the FDA issued the "Naming Guidelines for Recombinant Collagen Biomaterials", "Recombinant Collagen Classification of Medical Products Definition of the Principles", to promote the recombinant collagen in an orderly and rapid development.
Collagen can be used in the fields of medicine, medical cosmetology, cosmetics, food, light industry, etc.; among them, the application in the face value industry is based on:
1) Support: Type I collagen constitutes an elastic network in fibrous form in the skin to support the skin;
2) Repair: Promote the growth of fibroblasts;
3) Moisturizing: Collagen has a large number of hydrophilic groups, while hydrolyzed Glycine, alanine, aspartic acid and serine after hydrolysis are all natural moisturizing factors;
4) whitening: collagen is rich in tyrosine residues, which can compete with tyrosine in the skin and bind to the active center of tyrosinase, thus inhibiting melanin production.
Collagen in medical aesthetics: fillers, facial rejuvenation, dressings.
1) Fillers: collagen is suitable for filling the areas around the eyes (crow's feet, tear troughs, etc.), forehead, etc.; at present, there are 6 products from 4 companies that have been approved; among them, Jinbo Bio's "VYM" is the first recombinant collagen filler (recombinant collagen freeze-dried fibers of type III humanized collagen). Fiber). Under the two paths of extraction method and genetic recombination, there are many companies carrying out research and development of collagen fillers and reviewing the report.
2) Facial rejuvenation: Collagen's 4 major effects are applicable to facial rejuvenation, and it has a promising future in mesotherapy.
3) Dressing: used for sedation and anti-inflammation after medical aesthetic program, wound repair, acne repair, repair of allergies and redness removal.
Collagen used in skin care products: anti-aging, whitening, moisturizing.
Principle of action: Collagen hydrolyzed oligopeptide can activate Smad signaling pathway, up-regulate the expression level of TGF-βRII, thus increasing the expression of type I and type III pre-collagen mRNA (COL1A2 and COL3A1); oligopeptide can inhibit the synthesis of MMP-1 that destroys collagen, and also affect the expression of some of the genes in fibroblast cells. gene expression while inducing collagen and hyaluronic acid production. High-end brands such as FELOCA and Estee Lauder have collagen product lines, and skincare products such as Giant Bio, Jinbo Bio, and Beauty Law (a subsidiary of Marumi) focus on recombinant collagen.
Trend outlook: dressings and cosmetics provide profits and cash flow, R&D for aesthetic use and medical products to layout the future.
Currently, the head of the extraction method and genetically engineered collagen enterprise revenue and profit generally mainly from the face value industry scenario, such as dressings and cosmetics. Relying on R&D and financial strength, each head collagen enterprise is making efforts to research and develop medical products and medical aesthetic class III medical devices, etc., and such products will be listed in large quantities in the next 3~5 years; the head enterprises will form a multi-scenario, multi-effective product matrix, such as medical-medical aesthetics-cosmetics-food and beverage.
Risks:
Tightening of regulations, the incubation of new brands slows down, but in the long run, it is conducive to the healthy development of the industry; dressings, strong efficacy of the impact of the traditional cosmetic skin care products market.
This article originated from the financial sector network