Pharmaceutical industry pollutant emission standards

Pharmaceutical industry is an important part of the national economy, China's total economic growth has made an important contribution, but at the same time also caused more serious environmental pollution. It is reported that the State Environmental Protection Administration in order to strengthen the environmental management of pharmaceutical enterprises to reduce the intensity of emissions, is working on the development of pharmaceutical industry pollutant emission standards. A few days ago, the reporter interviewed the State Environmental Protection Administration of Science and Technology Standards Division responsible person (hereinafter referred to as "responsible person").

Reporter: The state has promulgated the "Comprehensive Emission Standards for Sewage" and "Comprehensive Emission Standards for Air Pollutants", why

but also for the pharmaceutical companies to develop special emission standards?

Responsible: Pollutant emission standards is the control of pollution sources of the basic legal system, is the basis for environmental law enforcement, but also the green development of the enterprise signposts. Emission standards are based on the use of the best available pollution control technology, and take into account the affordability, the harmful substances discharged into the environment and the production of pollution of various factors to make the restrictive provisions. They are formulated on the basis of pollution control technologies (production processes, pollution prevention, end-of-pipe treatment, etc.), taking into account environmental risks; they are expressed mainly in terms of numerical limits, but also in terms of operational standards and technical management norms. In order to enhance the relevance and operability of the standard, I have in recent years increased the development of industry-type pollutant emission standards work, and gradually by the comprehensive type, industry-type parallel emission standards system, the transition to industry-based emission standards system, increase the coverage of industry-type emission standards, and gradually reduce the scope of application of general-purpose pollutant emission standards. According to incomplete statistics, China's raw materials and pharmaceutical preparations production of more than 5,000 enterprises, with a large number of enterprises, small-scale, decentralized layout, the production process of raw material inputs, the output ratio of small, high value-added products, pollution problems and other characteristics. Therefore, specifically for pharmaceutical companies to develop emission standards is very necessary.

Reporter: pharmaceutical industry pollutant emission standards preparation work progress?

Responsible for: I started in 2003 to start the pharmaceutical industry pollutant emission standards development work. First carried out a study of the standard system, in a comprehensive analysis of the domestic and foreign pharmaceutical industry production process, the characteristics of sewage on the basis of the characteristics of China's pharmaceutical industry and the need for environmental management, to determine the standard system of discharge of pollutants in the pharmaceutical industry, including fermentation, chemical synthesis, extraction, bio-engineering, traditional Chinese medicine, and mixing and preparation of six categories. 2004 the end of the Bureau of the standard issued by the task of compiling the standard, set up by the Hebei Academy of Environmental Sciences, led by Halsey, and the Chinese Academy of Sciences, and the Chinese Academy of Sciences. At the end of 2004, our bureau issued the task of standard preparation, and set up a standard preparation group led by Hebei Academy of Environmental Sciences, with the participation of Harbin Institute of Technology, East China University of Science and Technology, and Standard Institute of SEPA, etc. At the end of April, 2005, the Department of Science and Technology Standards of SEPA held a discussion meeting on the opening report of the six types of standards in Beijing. After that, the standard preparation group went to the typical pharmaceutical enterprises in Hebei, Heilongjiang, Jilin, Liaoning, Tianjin, Shandong, Guangdong, Hubei and other provinces to carry out field research and information collection and standard drafting work, at present, the first draft of the standard has been formed. Recently to seek the views of localities, departments and enterprises.

Reporter: The General Administration of the "pharmaceutical industry pollutant emission standards" of the development of what specific requirements?

Responsible for: the General Administration of the industry emission standards are mainly the following requirements: First, highlight the characteristics of the pharmaceutical industry pollution, focusing on the control of human health and ecological hazards caused by toxic and hazardous substances; second is to highlight the industry's pollution control technology and cleaner production technology, and to promote the application of advanced technology in the governance project; third is to continuously improve the threshold of environmental access, and to promote the structural adjustment of the pharmaceutical industry, efforts to the Advanced countries production level, advanced technology; Fourth, reflecting the principle of differentiation between old and new sources, new sources from strict control, reflecting the forward-looking and rolling.

Reporter: emission standards from the start to the final introduction of what to do?

Responsible for: In accordance with the national environmental standards preparation procedures and requirements, the preparation cycle of emission standards is generally two years, particularly complex projects can be extended appropriately. Pharmaceutical Industry Pollutant Emission Standards" has formed the first draft of the standard, the next step in a certain range of discussions, will be open to the nation for comment, the scope of the consultation includes environmental protection systems, industry associations, pharmaceutical companies, research institutes and so on. All units and individuals concerned about the pharmaceutical industry pollutant emission standards can put forward comments and suggestions. I will promptly organize the preparation group to study the views put forward by the units, modify and improve the standard text, and in due course to convene an expert review of the standard for technical review. After the expert review, and finally by the Bureau held a meeting to review and approve the release in conjunction with the General Administration of Quality Supervision, Inspection and Quarantine.

Reporter: You think pharmaceutical companies in the standard preparation process should play what role, what role?

Responsible for: emission standards for mandatory requirements, China's relevant environmental laws have been clearly stipulated that "exceeding the sewage discharge is illegal," therefore, the majority of enterprises should be regarded as the emission standards as the lifeline of the enterprise, to meet the emission standards as their own social responsibility. I hope that the majority of pharmaceutical companies to pay attention to and actively participate in the preparation of standards, advice and suggestions, so that the development of the standard is more perfect and scientific, in line with the level of corporate pollution control technology and affordability, to meet the national environmental management and pollution control requirements.

Reporter: Finally, please tell us the purpose of the "Pharmaceutical Industry Pollution Prevention Technology Policy and Emission Standards Seminar" organized by the General Administration?

Reporter: Finally, could you tell us the purpose of "Pharmaceutical Industry Pollution Prevention and Control Technology Policy and Emission Standard Seminar"? This meeting is intended to study the pharmaceutical industry emission standards division system, the six types of standards for discussion of the first draft of the pharmaceutical enterprises on pollution control technology and cleaner production processes for exchange, is a pharmaceutical industry pollutant emission standards for the preparation of the meeting, is a unified thinking, consulting, exchange of information, *** with the improvement of the meeting.

National Environmental Protection Engineering Technology Center for Pharmaceutical Wastewater Pollution Control

National Environmental Protection Engineering Technology Center for Pharmaceutical Wastewater Pollution Control (hereinafter referred to as the "Engineering Technology Center"), approved by the State Environmental Protection Administration to establish the pharmaceutical industry to carry out environmental protection work of the technical functions of the institution. It is under the policy guidance and business management of the State Environmental Protection Administration. Its main purpose is to provide technical support and services for solving the major scientific and technological problems of pharmaceutical industry environmental protection, promoting the development of environmental protection high-tech industry, and realizing the national pharmaceutical industry environmental protection goals and sustainable development by building first-class R&D bases at home and abroad, applying the modern operation mechanism, and integrating the social scientific and technological resources.

"Engineering Technology Center" currently has a "central laboratory", "process laboratory", "pilot research base ", "production test base" and "demonstration enterprise group" as the main body, integrating scientific research, process development, engineering design, equipment manufacturing, operation and debugging, and can cohesion, release the "industry, academia, research and development". The main body of scientific research, process development, engineering design, equipment manufacturing, operation and commissioning, and can be cohesive, release, "industry, academia, research" joint research and development potential of the pharmaceutical industry, environmental science and technology innovation platform and industrialization of R & D base.

The center's laboratory is equipped with first-class analytical instruments at home and abroad, such as color and mass spectrometry, liquid chromatography, inductively coupled plasma mass spectrometry, total organic carbon tester, atomic absorption, Fourier infrared and other analytical instruments, as well as portable measuring instruments, such as COD, pH, SS, DO, etc., which can realize the identification of toxic substances in the pharmaceutical industry, the screening of biomarkers and the practical bio-toxicity of the monitoring technology, and provide a platform for the pharmaceutical industry's clean production and pollution prevention and control technology, as well as for the pharmaceutical industry's environmental technology innovation platform and industrial research base. It can realize the identification of toxic substances, biomarker screening and practical biotoxicology monitoring technology research in the pharmaceutical industry, and provide a platform for basic research and analysis test for the clean production and pollution prevention technology innovation in pharmaceutical industry.

The laboratory is equipped with nearly 100 sets of experimental simulation devices, including compound anaerobic granular bed reactor (HAR), CASS reactor, membrane bioreactor (MBR) and so on. Among them, the small test platform is designed for the pollution characteristics of pharmaceutical wastewater, with advanced automatic control system, while the treatment unit can be freely combined and switched, can maximize the processing monitoring data and access to process parameters, to carry out research and development of high technology in the industry, wastewater treatment engineering design of the pre-consultation to provide technical support and services.

Pilot research base with a variety of types of pharmaceutical wastewater sources, built high-efficiency anaerobic, aerobic, membrane bioreactors and water resources, such as advanced medium-sized expansion of the test equipment, can be switched according to the needs of the realization of the unit for the pharmaceutical wastewater pollution prevention and control of water resources technology to amplify the results of the pilot study and the research and development of high-efficiency treatment equipment to provide process parameters for the scientific research results for the holders of research results, research units, It provides comprehensive test conditions for the comprehensive transformation of scientific research results and rapid popularization and application of new technologies for holders of scientific research results, research units, engineering design units and pharmaceutical and environmental protection enterprises.

The productive test base brings together dozens of wastewater and solid waste from biopharmaceuticals, chemical synthesis pharmaceuticals and many other pharmaceutical companies, which can realize the amplification test of scientific research results to industrial application and the test of safe disposal of major pollutants, and achieve the optimal combination of the overall process and the economic coupling of the treatment efficacy of the experimental validation of the purpose of the selection and optimization of the wastewater treatment process of different varieties of pharmaceuticals to provide long-term and stable technical reserves. The test is aimed at optimizing the overall process combination and economic coupling of treatment efficiencies, and providing long-term stable technical reserves and support for the selection and optimization of different pharmaceutical wastewater treatment processes.

Demonstration enterprise groups rely on North China Pharmaceutical and Shijiazhuang Pharmaceutical Group and other two groups of more than 70 enterprises to build, covering fermentation, chemical synthesis, semi-synthetic, extraction and traditional Chinese medicine, bioengineering, preparation and other major categories, for the pharmaceutical industry, pollution control of the transformation of new technological achievements, the new high-efficiency industrialization of process equipment, as well as the promotion of cleaner production processes, technologies and methods to provide demonstration sites. The site.

"Engineering and Technology Center" has set up stable research directions, including the research, development and application of key technologies and complete sets of equipment for pharmaceutical wastewater treatment, informatization and optimization of water resource management in the pharmaceutical industry, construction of ecological safety of pharmaceutical industrial waste and emergency response system for major accidents, green product design and clean production, and research on technical policies and standards for pollution control in the pharmaceutical industry. The research of pollution prevention technology policy and standard of pharmaceutical industry. Based on the tenet of "socialization of R&D system, industrialization of scientific and technological achievements, entrepreneurial operation mechanism and market-oriented development", the center mainly carries out the R&D and industrialization projects of pollution prevention and ecological protection*** technologies and key technologies, constructs demonstration projects of new environmental protection technologies, and promotes advanced environmental protection technologies and products, and carries out domestic and international technical exchanges and cooperation, and introduces, develops and promotes new environmental protection technologies and products, international technical exchanges and cooperation, the introduction, digestion, absorption of foreign advanced technology and equipment; cultivate senior environmental engineering and technical personnel and management personnel; carry out research and development of environmental protection technology policies, technical standards and norms in related fields; undertake related engineering technology assessment and engineering verification; carry out environmental technology consulting and technical services.

"Engineering Technology Center" draws on advanced operation and management experience at home and abroad, and has initially formed an operation mechanism and management concept that can cohesively release the potential of joint research and development of "industry, academia and research". Through mechanism innovation and integration of limited scientific and technological resources such as social and scientific human resources, scientific research material conditions and research and development funds, in accordance with the national guidelines for scientific and technological development of "independent innovation, key leapfrogging, supporting the development and leading the future", the center openly solicits scientific and technological needs from the society in terms of research and development direction, and openly recruits chief specialists for major research and development projects and projects.

Over the years, the Engineering Technology Center has carried out a series of research and engineering practice on pollution prevention and control technologies of high concentration and difficult to degrade organic wastewater in the pharmaceutical and other industrial sectors, and has achieved a number of successes, including hydrolysis acidification-membrane bioreactor technology for treating difficult to degrade organic wastewater with a high concentration, anaerobic-aerobic bioreactor technology for organic wastewater, medium-temperature upflow anaerobic wastewater treatment, and medium-temperature upflow anaerobic wastewater treatment. We have achieved more than 40 achievements and technologies, including hydrolysis-acidification-membrane bioreactor technology to treat difficult-to-degrade high concentration organic wastewater, anaerobic- aerobic bioreactor organic wastewater treatment technology, mid-temperature up-flow anaerobic sludge bed (UASB) reactor high concentration organic wastewater treatment technology, high activity anaerobic granular sludge industrial production technology, high sulphur biogas desulphurization technology, anaerobic treatment of Vc wastewater reflux technology, high efficiency inner-cycle anaerobic reactor application technology, sulphur-containing organic wastewater treatment method and special equipment for gas cleaning, organic fertilizer production technology of Hb bacterial residue and penicillin residue. More than 40 achievements and technologies, including hydrolysis acidification-membrane bioreactor treatment of difficult to degrade high concentration organic wastewater technology, medium temperature upflow anaerobic sludge bed (UASB) reactor high concentration organic wastewater treatment technology, high-activity anaerobic granular sludge industrial production technology, sulfur-containing organic wastewater treatment methods and special equipment for gas purification and other achievements have won the National Provincial and Ministerial Science and Technology Progress Award and invention patents. The achievements of the company, such as scientific and technological progress awards and invention patents, have won national provincial and ministerial-level awards.

HAIZHENG PHARMACEUTICALS

Building EHS system, taking the road of sustainable development

Zhejiang Haizheng Pharmaceutical Co., Ltd. was founded in 1956, is one of the largest production bases of antibiotics and antitumor drugs in China, and has already possessed the production bases of antitumor, antiparasitism, cardiovascular system, anti-infectives (including β-lactam enzyme inhibitor), immunosuppressants, immunosuppressant, anti-infective, and antitumor drugs. ), immunosuppressants, endocrine regulators, antidepressants and other seven categories of products.

Taking circular economy as the entry point, realizing the change of economic growth mode

Hai Zheng Pharmaceutical is focusing on the idea of "reducing the emission of three wastes, reducing the consumption of solvents, and reducing the cost of production", and vigorously develops the circular economy, realizing the change of economic growth mode.

On the basis of the existing solvent recovery, the company summarizes its experience and establishes a new organic solvent recovery center according to the products that have been put into production and pre-production, as well as the quantity and nature of various solvents used.

The company set up a fermentation workshop in the outer sand plant as a pilot, motor frequency conversion energy-saving technological transformation, energy-saving effect is remarkable, the power saving rate of more than 12%, high-frequency harmonics in the supply and use of power circuits, transient voltages, inrush currents have been effectively curbed, and the equipment failure rate has been reduced.

The company improved the reuse rate of cooling water and deionized wastewater, which can reduce the water consumption in other links to achieve the purpose of water saving. At present, the company's outer sand plant through the recycling of water, the total amount of water consumption has been reduced by nearly 50%.

The company also carries out comprehensive utilization of fermentation waste development, fermentation waste add soybean meal and other re-fermentation, the development of organic fertilizers, turning waste into treasure, increase revenue, the current small test has been successful.

Focus on clean production, comprehensive improvement of equipment and technology

Hai Zheng Pharmaceutical in the process of clean production has always been to improve the equipment and improve the level of technology as the focus of work.

The transformation of the fermentation tail gas treatment system focuses on solving the disorganized emissions. The company uses high-efficiency cyclone separation technology and water film spraying device, the vacuum pump exhaust, induced draft fan exhaust and fermentation residue air drying exhaust for remediation, the sewage treatment station covered and closed, the installation of spray absorption device and biological desulfurization device, so that the separation efficiency of the gas is high up to more than 95%, the gas discharged after the separation of the gas is clean and clean, no fermentation liquid and foam brought out to meet the tail gas emission standards.

Using advanced microfiltration and nanofiltration equipment to pre-treat the fermentation broth of tumor antibiotic products, the product yield can be increased by 20-30%, while greatly reducing wastewater discharge. Therefore, the company intends to introduce foreign advanced membrane filtration equipment to carry out technological transformation of the workshop in Yantou factory.

Taking structural adjustment as the root, constructing the advantages of bio-industry

Hai Zheng Pharmaceutical has always taken the adjustment of industrial and product structure as the root of the comprehensive implementation of clean production. While continuously eliminating old products with high pollution, it develops new industries with high efficiency, low consumption, low pollution or basically no pollution.

The company strives to extend the industrial chain, focusing on the development of low-energy consumption, low-pollution, high-efficiency high-tech products, and continuously expanding the research and development and production capacity of APIs and pharmaceutical preparations, and speeding up the pace of API preparations to enter the mainstream market of Europe and the U.S. while exporting APIs, so as to form the four major emerging industries as soon as possible, such as natural medicines, export preparations, genetically recombinant drugs, and the R&D industry.

As a developing enterprise, Hai Zheng Pharmaceutical is now facing the economic transformation from traditional development to scientific development. The company takes environmental protection, safe production and social harmony as its basic policy, and realizes sustainable development as its major strategy. It carries out large-scale company-wide activities in source control, pollution prevention and control, risk assessment, clean production, health and safety, hazard identification, fire prevention and disaster prevention, and community communication to promote the process of building a modernized enterprise.