1, use:Clinical application of opioids acute poisoning relief. It is used in opioid overdose poisoning. Preferred for known or suspected opioid overdose caused by respiratory depression and coma, can quickly improve breathing, so that conscious; opioid analgesia, cardiovascular, gastrointestinal effects, pupil constriction, endocrine effects can be counteracted. For opioid-dependent patients, it can prompt withdrawal reactions at the same time, and attention should be paid to the difference. This product can also antagonize the agonist pentazocine anxiety and psychotomimetic effects, ② relief of postoperative respiratory depression of opioid anesthesia. Morphine, fentanyl, pethidine, etc. for intravenous compound anesthesia or anesthesia auxiliary drugs, postoperative respiratory depression is still obvious, can be divided into static injection or intramuscular injection of a small dose of this product, moderate reversal of respiratory depression. Excessive dosage or administration too fast, can be canceled at the same time or significantly weaken the analgesic effect of opioids, causing nausea, vomiting, sudden rise in blood pressure, tachycardia, shortness of breath and other reactions, so special attention should be paid to mastering the dosage and the speed of administration of i ③ Differential diagnosis of opioid addicts (drug addicts). For opioids such as morphine, methadone, pethidine, especially diacetylmorphine dependent people, intramuscular injection of this product can stimulate a severe withdrawal reaction, combined with the history of drug use and urinalysis results, can be confirmed for opioid addiction, but naloxone differential test negative, can not be ruled out positive opioid dependence; ④ can be used for the rescue of acute poisoning of alcohol, toxic shock (restore blood pressure).
2, dosage: adults intramuscular injection, static or IV 0.4 ~ 2mg / times, if necessary, can be repeated after 10min, children's initial dose of 0.01mg / kg; neonates with 10 ~ 60ug / kg. ① for opioid overdose poisoning, adults or children can be static or intramuscular injection of 0.4mg, repeated every 2 ~ 3min, until respiration is restored; because the The short duration of action of this product, methadone and other overdose, reversal of respiratory depression, every 20 ~ 60min should be repeated intramuscular injection of 0.4mg; ② for opioid-induced postoperative respiratory depression, adults intramuscular injection of 0.1 ~ 0.2mg or 1.5μg/kg, 3 ~ 5min can be added to the same amount; or static injection of 40μg every 2 ~ 3min to achieve the desired effect; ③ for the differential diagnosis of opioid-dependent people Diagnosis, intramuscular injection of 0.4mg, no response within 20 ~ 30min can be re-injected 0.4mg.