The human body 200 ml of venous blood, injected into the sterilization container with anticoagulant, and then injected into the container has been prepared about 200 ml of medical oxygen gas mixture, through the strong oxidation of medical oxygen on the blood "filtering" treatment, and then back to the patient to infuse the blood The blood is then re-infused into the patient's vein.
No surgery, no injection, no medicine, only through such a simple operation of blood extraction and transfusion of blood, the treatment of its indications cover three high, cerebral infarction, insomnia, chronic fatigue syndrome, headache, post-herpetic neuralgia, chronic hepatitis, lower limb arterial ischemia, gout, chronic ischemic heart disease, cancer adjuvant therapy, deafness, asthma, and other more than a dozen kinds of diseases.
This is the "three-oxygen macroautohemotherapy", in addition to the medical institutions called "safe and reliable, efficacy, fast, green, no dependence, without hospitalization with the treatment," but also some of the health care institutions publicized as a "miraculous face. The "miraculous face", and even hospitals try to use this therapy for the treatment of new crowns of patients with serious illnesses.
However, there have been questions about triple oxygen therapy, and those who don't believe in it have dismissed it as an IQ tax and a scam. In the question "which pseudo-science is the most offensive to you" in Zhihu, of the 1,818 answers, the most liked answer is to expose the medical aesthetic industry's "purification of blood program", the principle and operation of which are the same as triple-oxygen therapy.
But in many public hospitals, triple-oxygen therapy is being vigorously promoted as a featured technique. Is this an IQ tax, or is it an under-researched new direction in medicine with unlimited potential?
Low level of evidence, not recommended?
The skepticism about triple oxygen therapy is not unfounded.
In June 2018, the open mailbox of the Beibei district government in Chongqing received a letter about "Is ozone macroautohemotherapy legal?" The letter was sent to the district health committee, which replied: after investigation, there is no ozone macroautohemotherapy subject in the current diagnostic and treatment subjects.
In May 2018, Ningbo Evening News reported that Ningbo Sunshine Boai Rehabilitation Hospital was investigated for providing triple oxygen therapy. The hospital charges 30,000 yuan for a course of three-oxygen therapy and refers to patients as "family members", but also said that after paying 30,000 yuan for treatment, you can also get shares in the program, and with the more people receiving three-oxygen therapy treatment in the hospital, the hospital will arrange dividends every month, and the cost of the treatment can be recovered in about half a year, and the more relatives and friends the patient refers to receive the three-oxygen therapy, the more you can get a bonus, and the more patients can receive the three-oxygen therapy treatment. The more relatives and friends you have, the more shares you can get.
Ningbo Jiangbei Health and Market Supervision Department investigated Ningbo Sunshine Boai Rehabilitation Hospital, and then the hospital posted a notice to "renovate the three-oxygen therapy room according to the aseptic operation" in the name of suspending the treatment. However, it is also said that "after the renovation, the hospital will report to the Health Bureau for acceptance and review, after which it will notify everyone to start doing".
According to the report, the Jiangbei Health Supervision Office of medical disputes, said they have judged the so-called "three oxygen therapy" for illegal behavior, should be resolutely banned, will from time to time door-to-door spot checks; has produced charges, by the two sides to coordinate the settlement.
In Malaysia, although triple oxygen therapy has not been banned, the Malaysian Ministry of Health's attitude towards the therapy is "not recommended" because of its low level of clinical evidence.
In 2018, relevant experts from the Pain Group of the Anesthesiology Branch of the Chinese Medical Association, the Anesthesiologists Branch of the Chinese Physicians Association, and the Tricyclooxygenation Group of the Pain Branch of the Chinese Society of Ethnomedicine jointly formulated the "Tricyclooxygenated Autologous Blood Therapy Expert **** Knowledge". "*** knowledge" based on evidence-based medicine, reference to the U.S. Preventive Services Task Force and the Oxford Center for Evidence-Based Medicine disease level of evidence development methodology, the three oxygen therapy treatment of the disease level of evidence is divided into four categories, there is class A evidence of the indications for the absence of.
It is becoming a "medical specialty" in many hospitals
The lack of high-level evidence is not due to the fact that triple-oxygen therapy is the latest medical discovery, but rather that it has been transformed from a therapy into a medical science in China.
China Medical University Aviation General Hospital vice president Kuan Jianxiong is an active promoter of China's three oxygen medicine, "three oxygen autologous blood therapy experts *** knowledge" is led by him to develop, he also edited the publication of the "three oxygen medicine", and organized the "three oxygen medicine in China", hospital tours in various provinces and cities of the country to cultivate three oxygen medicine talents.
In the first chapter of "Triple Oxygen Medicine", the history of clinical application of triple oxygen is introduced: it can be traced back to the beginning of the 20th century, in 1915, doctors in Berlin first used triple oxygen to treat dermatological diseases, and then triple oxygen was used by the German army as an anti-infective drug for the treatment of anaerobic infections of open wounds in wars, and used by the German dentists for the treatment of oral infections. 1936, the French doctor Aubourg used O2-oxidation to treat anaerobic infections of open wounds. Aubourg injected O2-O3 gas mixture into the rectum to treat chronic enteritis and intestinal fistula, which was the first application of rectal triple-oxygen perfusion.In 1958, Germany's Joaquim Hansler invented the first triple-oxygen generator whose concentration and dosage could be adjusted, and in 1968, Wolff applied triple-oxygen autologous blood therapy to treat diseases for the first time and in 1972, together with Hansler, the Medical Triple-Oxygen Society was established. He founded the Medical Trioxic Society in 1972 with Hansler.
Yu Baofa was the first to introduce triple-oxygen therapy to China for cancer treatment in 1999, and He introduced triple-oxygen therapy to treat lumbar disc herniation and other diseases in 2000, and a variety of triple-oxygen therapies have been popularized in China over the past 20 years.
Despite the persistent skepticism about triple-oxygen therapy and the lack of high-level evidence-based medical evidence, triple-oxygen therapy has not only been highly sought after by medical aesthetics and private medical institutions, but also by many public hospitals that have carried out this treatment program and promoted it as a medical specialty of their departments.
As of July this year, the "Three Oxygen Medicine China Tour" has held 96 lectures, and the host hospitals include Xiangya Hospital, Weifang Medical College, the People's Hospital of Wuhan University, the First Hospital of Jilin University, the Second Hospital of Harbin Medical University, Qilu Hospital, Dongfang Hospital of Tongji University in Shanghai, and the Aerospace Center Hospital of Peking University, The Second Affiliated Hospital of Tianjin Medical University, Shaw Hospital of Nanjing Medical University, The Second Affiliated Hospital of Dalian Medical University, The First Hospital of Tsinghua University, The First Hospital of Lanzhou City, and the Aviation General Hospital of China Medical University, and other medical centers and research institutes.
According to information on the official website of the medical department of Tianjin University, at the beginning of the epidemic, Tianjin University quickly integrated the scientific research strength and clinical resources of the medical department of the university and the affiliated Haihe Hospital, and proposed the medical triple-oxygen fusion program for the treatment of patients' autologous blood after an in-depth research and judgment of the clinical manifestations of the new coronary pneumonia.
The clinical trial research plan for autologous blood triple oxygen therapy for new crown pneumonia was finalized on Feb. 16, 2020, and passed the ethical review of Haihe Hospital and the audit of China Clinical Trial Registry. Haihe Hospital reported that it successfully treated four confirmed cases of COVID-19 virus pneumonia, including critical cases, with this therapy, which was later included in a special report on the "Tianjin Model" for the treatment of neocoronavirus pneumonia, published by the Tianjin Municipal Commission of Health on March 4, 2020, which was published by the Tianjin Municipal Commission of Health.
Wuhan Municipal Central Hospital pain department director Cai Yi told the "medical world" in the field of pain treatment, three oxygen therapy has been carried out in many public hospitals, but the three oxygen therapy is still not the mainstream means of treatment, only to play a supporting role, the three hospitals are more cautious, in some medical institutions, private hospitals If the process is not standardized and professional, it may cause serious adverse consequences.
Effective, how effective?
Cai Yi told the medical profession, ozone has an anti-inflammatory and analgesic effect, and the principle of hyperbaric chamber is more similar, especially in the field of pain management has been a relatively wide range of applications, there are also some studies have proved that the treatment of hepatitis, insomnia, three highs, high uric acid and so on have a certain role, but it is not possible to be 100 percent effective.
But experts in non-pain fields are not so favorable and forgiving of triple oxygen therapy.
"The use of triple oxygen therapy to treat the 'three highs' is a complete flim-flam and a money scam, and promoting this is just a way to bring in money." Famous cardiovascular disease expert Hu Daiyi told the "medical world", the ordinary three high patients, normal medication has been very good results, spend a lot of money on three oxygen therapy is no better than more exercise, less oil and salt, diet control. "Are some private hospitals have no money to earn before engaging in a large self-blood program, regular hospitals are not carrying out these."
In the field of infectious diseases, there are also hepatologists who point out that there are no reliable and relevant papers or data on hepatitis treatment to support the effectiveness of triple-oxygen therapy, and there is no mention of similar treatments in the Guidelines for the Prevention and Control of Chronic Hepatitis B.
Meanwhile, on some legal counseling or medical communication platforms, there are also many requests for help or complaints from victims who claim to have been deceived by trioxane therapy.
"I am a sophomore in Changsha, a year ago my grandfather found out that he suffered from Hepatitis B Triple Yang, the whole family is very anxious, and inadvertently discovered a hospital in Wuhan has three oxygen autologous blood transfusion therapy, said it can be completely cured. At first, the doctor told us that the treatment of 2-3 courses of treatment is good, but in the treatment of half a year there, grandfather's disease does not get better so that the cost of treatment will be a bottomless pit, and then to grandfather changed to another regular hospital to receive treatment."
"The biggest problem now is over-publicity and abuse. Three-oxygen therapy claimed to be able to treat the original are not very good treatment of the disease, before carrying out treatment to make it clear to the patient, it may be effective but only auxiliary role, can not replace the traditional means of mainstream treatment, lowering blood pressure medication, hepatitis medication should be eaten still have to eat." Cai Yi said.
As the leader and promoter of triple-oxygen medicine in China, Prof. An Jianxiong does not believe that triple-oxygen therapy plays only a supplementary role.
Professor An introduced to the "medical world", the two techniques commonly used in the clinical treatment of pain: hormone and nerve destruction, the facts have proved that the road of pain treatment is very narrow, the patient often relapses, or ineffective, and even cause complications, so we need to find a way to repair the nerves, and can regulate the nerves. of the ideal therapy.
In Prof. An's opinion, triple oxygen therapy is the "ideal therapy" he is looking for. "With triple-oxygen therapy, along with other neuromodulation techniques, we have seen a dramatic increase in the long-term outcome of patients and a dramatic reduction in complications. Once we saw the advantages over traditional therapies, we began exploring broader applications and basic laboratory research on triple oxygen therapy."
Has trioxane autologous blood therapy been abandoned?
In December 2019, the General Office of the National Health and Wellness Commission issued a notice on "Guidelines for the Construction of Anesthesiology Department's Medical Service Capacity," and in the list of "Anesthesia and Pain Treatment Techniques" in Annex 3, "Catalogue of Anesthesia Key Techniques, "Three oxygen injection" and "three oxygen autologous blood therapy" are also listed.
As an active promoter of triple-oxygen medicine in China, Prof. An has basically abandoned "triple-oxygen autologous blood therapy" and shifted his research direction to triple-oxygen localized target therapy and rectal triple-oxygen perfusion therapy.
"We are now promoting triple oxygen medicine is not autologous blood therapy, but trioxide water local injection, we published trigeminal neuralgia, post-herpetic neuralgia, femoral head necrosis and chronic pelvic pain are using trioxide water, trioxide autologous blood therapy may have advantages for immune diseases, but we have also basically replaced it with rectal trioxide perfusion therapy, which doesn't involve blood and would be safer."
Professor An Jianxiong said image-guided lesion-targeted trioxane injections have become their mainstream method of treating pain disorders. But trioxane autologous blood therapy is still the mainstream in many hospitals in China, as well as in the medical aesthetic market, a market that An hopes will be regulated.
"There are fewer doctors practicing triple-oxygen medicine, and many of them just use the therapy and don't do research or publish articles, so it's harder to be convincing, and we're now trying to influence more people through research and article publication. Of course, it is also true that some organizations are profiteering with triple oxygen therapy. These facts are also very clear and will be gradually regulated. Medicine should still be human-centered, to solve the patient's problems, first of all, should adhere to the principle of non-harm, can not do things that jeopardize the interests of the patient, if you use this to get rich, is certainly against the purpose of medicine."
Professor An Jianxiong's team had an article on triple oxygen therapy applied to the treatment of necrosis of the femoral head online this month, which had previously been accepted by Pain Physician, the official journal of the American Society of Interventional Pain Physicians. According to Prof. An, they have demonstrated for the first time that there are alternative therapies to the classic treatment of artificial joint replacement."
The traditional treatment for necrosis of the femoral head is to replace the artificial joint, Prof. An claimed that their use of triple-oxygen therapy to treat necrosis of the femoral head is more than 90% effective, and 70%-80% can achieve clinical cure, with the patient being able to return to a normal life. For especially early patients with osteonecrosis of the femoral head, it can be anatomically cured.
For three-oxygen therapy, the Chinese Medical Association, anesthesiology branch of the tenth chairman of Professor Yu Buwei said, for many short-term efficacy is not significant intractable diseases, such as intractable insomnia, etc., three-oxygen therapy should have a certain efficacy, especially in some medical conditions are not too good place, very market, the patient's clinical subjective feeling is not bad.
"After all, many of the diseases of the big hospitals do not have a particularly good therapy, so there is a certain market space, but there is no charge standard, some prudent public hospitals will refer to the blood transfusion, hemodialysis project to charge, some bold institutions will charge a high price directly. If everyone is not willing to manage, let it go a little more unorganized."