Hygrothermal sterilization method through saturated water vapor, boiling water or circulation steam sterilization method, high temperature and high pressure water vapor as a medium, due to the high latent heat of the steam, strong penetration, easy to make the protein denaturation or coagulation, and ultimately lead to the death of microorganisms, so the sterilization efficiency of this method is higher than that of the dry heat sterilization method, and has become the most commonly used in the process of sterilization of the production of pharmaceutical preparations. Moist heat sterilization method can be divided into: boiling sterilization, pasteurization, autoclave sterilization, circulation steam sterilization, and intermittent steam sterilization. p>Damp heat sterilization is widely used in the production process of Chinese medicine preparation. In the production of Chinese medicine preparation, how to sterilize is a big problem. In order to solve the technical problems of sterilization of Chinese herbal medicines, Chinese medicine tablets, Chinese medicine powder, some companies originally used ethanol gas sterilization method, but the method of low production efficiency, long production cycle, large energy consumption, labor and time-consuming.
Later, in the GMP certification technical reform stage, a medical device factory produced by the pressure steam sterilization system was verified. Through the repeated operation of the pressure steam sterilization technology demonstrated success in solving the problem of sterilization of Chinese herbal medicines, tablets, Chinese medicine powder and other materials. The sterilization effect is in line with the requirements of the Chinese Pharmacopoeia and the internal control standards of the production process, and can be effectively used to guide the production of safe and effective sterilization methods, with high practical value and promotion value.
Baidu Encyclopedia - Moist Heat Sterilization Method