Treatment of allergic rhinitis, Cheng Kung University proved: EWSC can slow down the symptoms
Taiwan dust mite allergic rhinitis due to a large number of people, the current medicine can only slow down the discomfort; the National Cheng Kung University Research Center for Allergy and Clinical Immunology Research Center after years of efforts to achieve significant results, the development of "very high therapeutic potential substances - nano-extreme water-soluble chitosan (Extensive water-soluble chitosan; EWSC)" has been proved to drop into the nasal cavity of mice dust mite allergic rhinitis. The Center for Allergy and Clinical Immunology, National Cheng Kung University Research Center, has obtained significant results after years of hard work in developing "Extensive water-soluble chitosan (EWSC), a highly therapeutic substance that has been shown to slow down the inflammation symptoms of mice with dust mite allergic rhinitis and inhibit the phenomenon of neuritis, which is a highly significant effect, and it will be introduced into clinical trials as soon as possible for the benefit of more patients.
Professor Wang Zhiyao held a presentation on May 17th at the Yunping Building on the Guangfu Campus of National Cheng Kung University; Professor Zhang Zhihan, Director of the Research Center of National Cheng Kung University, congratulated Professor Wang on behalf of President Su Huizhen. Prof. Chang Chih-Han said in his speech that for researchers, apart from publishing research papers in important journals and presenting their research results, it is more important for them to hope that their research will contribute to the society, and Prof. Wang Chih-yao has achieved both, and his results are helpful to the home, clinic, and daily life, and he hopes that they will be promoted to the international arena quickly. The University has always been a benchmark school for university-industry cooperation, and in the past few years it has strengthened its innovation and entrepreneurship in addition to technology transfer. Prof. Wang Zhiyao's research results will be directed towards technology transfer or the establishment of a new start-up company, and he hopes that the good results of research and development will be pushed to the society as soon as possible, and that the whole world will be able to enjoy the results of the research and development.
The research group of Prof. Chih-Yao Wang, Director of the Center for Allergy and Clinical Immunology, is the first to use it in the medical field of dust mite allergic rhinitis and has successfully found a therapeutic opportunity; the results of this research have been published in April 2017 in the Journal of Allergy and Clinical Immunology, the highest-ranked journal of allergy.
Prof. Chih-Yao Wang said that the occurrence of nasal allergy is related to the patient's over-sensitive nerve cells, which easily release allergic substances when encountering the outside world *** Animal experiments have shown that when EWSC is dripped into the nasal cavity of mice with dust mite allergic rhinitis, the release of allergic substances from the cells is significantly reduced, and further research on nerve growth factor (NGF) in mice has revealed that EWSC inhibits allergic inflammation by inhibiting the manufacture of nerve growth factor, which generates immunomodulation. Further research on NGF in mice revealed that EWSC inhibits allergic inflammation by inhibiting the production of NGF, resulting in immunomodulation; the therapeutic mechanism of EWSC comes from the inhibition of the neuroinflammatory system.
Professor Wang Zhiyao pointed out that the current medications for allergic rhinitis, including antihistamines and topical steroid nasal sprays, may cause side effects in the long term; the scientific community has confirmed that chitosan can be broken down by cells, and can be absorbed by the intestinal tract, the surface of mucous membranes, and the skin. It also triggers the innate immune response of immune cells, which can achieve the effect of anti-allergy and asthma treatment.
After determining that chitosan can reduce dust mite allergic reactions, Prof. Wang Zhiyao's team further led the international community in the development of nanosized extremely water-soluble butyricosan (EWSC), which significantly slowed down the inflammatory symptoms of allergic rhinitis in dust mite-allergic rhinitis in mice when dropped into the nasal cavity of dust mite-allergic rhinitis mice. Prof. Wang Zhiyao said that the mice breathed about 350 times per minute, and the nasal congestion (thickening of the nasal mucosa) of the mice dropped to more than 100 times per minute during the allergic rhinitis attack, and then resumed 350 times per minute after giving EWSC for a period of time.
Prof. Wang Zhiyao also said that EWSC has the advantage of being natural, non-toxic and biodegradable, and has the potential to be developed into a nasal spray for allergic rhinitis, providing an alternative or additional option to the existing medications used to treat allergic rhinitis in a preventive or therapeutic way.
Allergic rhinitis is a common disease in Taiwan, affecting almost 4 out of 10 children between the ages of 6 and 12, with dust mites accounting for the majority of allergic rhinitis. Taiwan's annual health care expenditure on allergic rhinitis is nearly 10 billion dollars, although allergic rhinitis does not cause fatal danger, but will affect the patient's daily life, if not properly treated, may still be complicated by asthma and increase the mortality rate.
Subscribe to the Healthy Love LOHAS Audio/Video Channel, read health knowledge more easily Join, every day attention to your health! LINE@ ID: @ : /supply/article/33034 Keywords: dust mites, allergic rhinitis, Success University Research Center, Allergy and Clinical Immunology Research Center, nano-extreme water-soluble chitosan, Extensive water- soluble chitosan