What is the principle of PCR What is the principle of PCR and what is it used for?

PCR is known as polymerase chain reaction, the principle is the in vitro amplification of DNA.

Specifically: after adding DNA, synthetic raw materials (dNTP, primers), and heat-resistant DNA polymerase (taq) into the EP tube, put it into the PCR instrument, which will use the elevated temperature to denature the DNA, and then make single-stranded replication into double-stranded replication under the action of the polymerase, which will lead to the purpose of gene replication.

Uses:

1, basic research on nucleic acids: genome cloning

2, asymmetric PCR to prepare single-stranded DNA for DNA sequencing

3, reverse PCR to determine the unknown DNA region

4, reverse transcription PCR (RT-PCR) for detecting the level of gene expression in the cell, the amount of RNA viruses and Direct cloning of cDNA for specific genes

5. Fluorescence quantitative PCR for real-time monitoring of PCR products

6. cDNA end rapid amplification technology

7. Detection of gene expression

8. Medical applications: detection of bacterial and viral diseases; diagnostics of genetic disorders; diagnostics of tumors; forensic forensic science