Not what antibody is good for the human body, like irregular antibody is harmful to the human body of a kind of antibody, and want to know whether the body has irregular antibody, then you can carry out the irregular antibody screening test to know, irregular antibody screening test is negative if the results are good, the next step we come to understand the irregular antibody screening test is what it is.
What does irregular antibody screening test mean
There are a variety of medical screening tests, of which irregular antibody screening test is what it means?
An irregular antibody screen is a test to check whether a pregnant woman has antibodies other than anti-A, anti-B, or anti-AB in her blood. Antibody screening is usually performed on the serum or plasma of blood donors to prevent blood containing irregular antibodies from being transfused to patients, to avoid hemolytic transfusion reactions, and to reduce blood waste.
Also, screening for irregular antibodies in patients needing transfusion therapy can prevent hemolytic transfusion reactions and ensure the safety of blood transfusion. In the case of pregnant women, irregular antibody screening can detect irregular antibodies as early as possible, prevent and treat hemolytic disease of the newborn during pregnancy, reduce the degree of venereal disease of hemolytic disease of the newborn, and improve the physical quality of the fetus or the newborn.
What does it mean to be negative for irregular antibody screening
It is necessary to do irregular antibody screening for some patients, so what does it mean to be negative for irregular antibody screening among them?
If the test is negative for irregular antibodies, the results are normal because irregular antibodies are antibodies in the body that cause hemolytic transfusion reactions and hemolysis in newborns. If this antibody is present, it may cause a hemolytic transfusion reaction or neonatal hemolysis. If an rh-negative mother is negative for irregular antibodies, it indicates that it has no effect on the development of the baby. However, if the irregular antibody is found to be positive, vigilance is necessary to avoid neonatal hemolysis.
At present, the United States, Japan, Australia and other countries have irregular antibody screening included in the routine measurement, while China's health administrative department has not yet required blood donors to carry out antibody screening, and only a few hospitals in the clinic for patients to carry out antibody screening. At present, most clinical hospitals in China, the blood transfusion department (or blood bank) of the level of blood matching is relatively backward, has been along the room temperature saline method of blood matching, this method can only be out of the mismatch of the IgM class of antibodies, can not be out of the mismatch of the IgG antibody, and the majority of antibodies other than the ABO blood grouping system of the system of the blood grouping system is the IgG nature of the antibody.
Irregular antibody screening is what kind of test
Irregular antibody screening is not a common test.
Irregular antibody screening is a test for blood transfusion. Irregular antibody screening refers to antibodies that do not conform to the Landsteiner's Law of the ABO blood group system, including ABO subtype antibodies and non-ABO blood group antibodies, mostly immune antibodies (IgG antibodies). There are two types of human blood group antibodies, IgG and IgM. It is now known that the anti-A and anti-B of the ABO blood group system are IgM, and the antibodies of other blood group systems are all IgG. IgM antibodies are able to coagulate with red blood cells containing the corresponding antigens with the naked eye in saline medium (traditional ABO blood group identification).
While IgG antibodies can only sensitize red blood cells to the corresponding antigen in saline media, they cannot cause red blood cells to coagulate, and the reaction between IgG antibodies and the corresponding red blood cells must be performed with the aid of an enzymatic test or an anti-human globulin test in order to produce a visible coagulation. In other words, the traditional saline blood grouping and cross-matching tests are only valid for the ABO blood grouping system, but not for many other blood grouping systems.
Irregular Antibody Screening for Women's Blood Typing
There are actually more tests for blood typing, among which irregular antibody screening for women's blood typing how to do it?
Irregular antibody screening for women's blood group identification: first of all, line up and label the patient's red blood cell suspension tube, the patient's plasma tube, the patient's ABO positive stereotyping tube, the patient's ABO anti-stereotyping tube, the patient's RhD stereotyping tube. Specimen preparation was then performed by separating the patient's plasma, taking one drop of pressure-accumulated erythrocytes, washing three times, and preparing the patient's 2%-5% erythrocyte suspension.
Then the samples were spiked: ABO positive sizing: 1 drop (50ul) of anti-A and anti-B reagents plus 1 drop (50ul) of the patient's erythrocyte suspension. ABO anti-stereotyping: 1 drop (50ul) of patient's serum plus 1 drop (50ul) of anti-stereotyping reagent erythrocytes. For RhD stereotyping: 1 drop (50ul) of anti-D serum plus 1 drop (50ul) of patient erythrocyte suspension. Then centrifuge (2 steps): gently shake the test tube, visual observation of agglutination, record the results of ABO, RhD blood type can be.