Which is safe, hyaluronic acid or polyacrylamide?

Which is safe, hyaluronic acid or polyacrylamide? Hyaluronic acid, scientifically known as hyaluronic acid, is a highly viscous substance first isolated from the vitreous humor of the cow's eye, and is a naturally occurring linear polysaccharide compound. Hyaluronic acid molecules contain multiple hydroxyl groups, has a very strong hydrophilicity, can combine a large number of water molecules, has a strong role in retaining water, can maintain a suitable wet environment between the cells, is a natural moisturizing factor.

Hyaluronic acid is an important substance for human skin tissue to retain moisture. Hyaluronic acid in the skin helps the skin to tolerate stress and protects the subcutaneous tissue from damage. Hyaluronic acid also acts as a lubricant, allowing the skin to change shape and volume at the right time as bones and joints move.

However, the distribution of endogenous hyaluronic acid in the skin and body is constantly changing. As we age, the decrease in hyaluronic acid and the corresponding decrease in the ability of hyaluronic acid to bind water molecules can lead to a decrease in skin volume, wrinkles, and dry skin. Therefore, hyaluronic acid is used in cosmetic surgery.

Hyaluronic acid products used in medical cosmetology passed the U.S. Food and Drug Administration (FDA) certification in December 2003, and in December 2008 passed the China Food and Drug Administration (SFDA) certification. The main adaptations of hyaluronic acid injections for cosmetic purposes include wrinkle removal, facial contouring, facial depression filling, lip augmentation, and so on.

Inadvertently, I found a notice on the official website of the State Food and Drug Administration (SFDA).On March 28, 2018, the State Food and Drug Administration (SFDA) issued a "Consumer Alert on Polyacrylamide Hydrogel (for injection)", and I was stunned at that time!

Why? Because polyacrylamide is carcinogenic!

Student biology, pharmacy or medicine-related professionals know that when doing molecular biology experiments, protein running gel used in polyacrylamide gel electrophoresis (SDS-PAGE), with the gel is always worried that it will be poisoned, and generally wear a mask, one of the highly toxic substances is polyacrylamide. But I don't know why it is used in the plastic surgery industry.

The toxicity of polyacrylamide specifically talk about. Polyacrylamide monomer is highly toxic, but after the formation of gel because of crosslinking, the toxicity is reduced. However, special attention should be paid to the polyacrylamide hydrogel injected into the human body, it may decompose and produce highly toxic. Due to the ability to decompose into highly toxic monomer molecules in the body, poisoning the nervous system, damaging the kidneys, and causing harm to the vital circulatory system, the World Health Organization has classified this substance as one of the suspected carcinogens.

The use of polyacrylamide hydrogel as a substitute for hyaluronic acid in cosmetic surgery is scary to think about!

The former State Food and Drug Administration (SFDA) revoked the "Medical Device Registration Certificate" of polyacrylamide hydrogel (for injection) and other related products on April 30, 2006, and completely stopped the production, operation, and use of the product.

But after checking the relevant information, I think the use of polyacrylamide hydrogel to replace hyaluronic acid for cosmetic surgery may be a historical legacy!