CRRT stands for Continuous Renal Replacement Therapy. Also known as CBP; bedside hemofiltration. The definition is the use of a prolonged, continuous extracorporeal blood purification therapy 24 hours a day or close to 24 hours a day to replace impaired kidney function.
CRRT is defined as all blood purification techniques that allow for the continuous removal of solutes and are supportive of organ function. During the Second World War, Murray and Delmore of Canada developed the first successful artificial kidney machine and used it for clinical treatment of renal failure in l946, after which blood purification techniques were rapidly developed.
Blood purification is to lead the patient's blood to the outside of the body and through a kind of purification device, remove some of the disease-causing substances to purify the blood to achieve the purpose of treatment of disease. It mainly includes hemodialysis, hemofiltration, hemodialysis filtration, hemoperfusion, plasma replacement, immunosorption, peritoneal dialysis and so on.
At present, blood purification therapy has not only been used to treat patients with acute and chronic renal failure, but has also been widely used in the rescue treatment of patients with acute and critical illnesses.
Expanded information:
The goal of the clinical application of CRRT is to remove the excessive water from the body, remove the The goal of CRRT is to remove excessive water, remove metabolic wastes and toxins from the body, correct water and electrolyte disorders, ensure nutritional support, promote the recovery of renal function and remove various cytokines and inflammatory mediators.
It can be used in the treatment of acute and chronic renal failure with unstable cardiovascular function, high catabolism or with cerebral edema, as well as multiple organ dysfunction syndrome, acute respiratory distress syndrome, extrusion syndrome, acute necrotizing pancreatitis, chronic heart failure, hepatic encephalopathy, and poisoning by medicines and toxins.
Principle
Diffusion: solute concentration difference - for small molecules such as urea, creatinine, Na+, K+
Convection: solute and solvent pressure difference - for small molecules, intermediate molecules such as a variety of inflammatory mediators
Adsorption: e.g., carbon canisters, resins, A-protein columns, etc.
To inflammatory mediators, cytokines, endotoxins
Reference: