Pharmacological action:
1, hemostasis, significantly promote platelet aggregation in rats and rabbits, enhance platelet activation percentage and platelet surface glycoprotein expression. It can shorten the coagulation time of rats and rabbits and has obvious contraction effect on rabbit arterial strips.
2. Promoting blood circulation and removing blood stasis: inhibiting venous thrombosis in rats, relieving microcirculation disturbance in rats caused by dextran, reducing whole blood viscosity in rats, improving blood flow state and accelerating auricular microcirculation blood flow velocity in mice. It has a certain effect on preventing acute capillary thrombosis in rats, and there will be no abnormal blood coagulation.
3. Anti-inflammatory: It has obvious antagonistic effect on animal inflammatory model caused by inflammatory factors such as adjuvant, carrageenan, foreign protein, chemical inflammatory factor and cotton ball tooth swelling. 4. Callus: It can significantly promote the expression of basic fibroblast growth factor (bEGF) and vascular endothelial growth factor (VEGF), thus accelerating the growth of blood vessels and promoting wound healing.
Palace can remove blood stasis and stop bleeding, promote blood circulation and relieve pain, detoxify and reduce swelling.
It is mainly used for treating traumatic injury, blood stasis, swelling and pain, hematemesis, hemoptysis, hematochezia, hemorrhoids, metrorrhagia, bronchial hemoptysis, pulmonary tuberculosis, ulcer bleeding, sores and swelling, soft tissue contusion, closed fracture and skin infectious diseases.
dosage
Knife wounds, gunshot wounds and falls, regardless of severity, should be taken by the bleeding person with warm water; Blood stasis, swelling and pain, no bleeding, take wine; Gynecology, take it with wine; However, those with excessive blood volume and redness should be taken with warm boiled water; At the beginning of toxic ulcer, take 0.25 g, and apply another powder to the affected area after mixing with wine. If suppurative, take it orally. Other symptoms of internal bleeding can be taken orally.
Oral administration: 0.25-0.5g once, four times a day (2-5 years old1/4,5-12 years old 1/2).
In case of a serious fall, you can take a red insurance policy first, and you don't have to take minor injuries and other diseases.
Matters needing attention
1, taboo: not for pregnant women.
2. Use with caution those who have allergic history to this drug or have a family allergic history. It is not suitable for patients with severe arrhythmia.
3. If there is tissue damage or infection, it must be thoroughly debrided, rinsed and disinfected before external use. Some patients may have a slight burning sensation after external application of Yunnan Baiyao, which will gradually disappear with the improvement of their condition.
Each gauge contains 0.25g, and each box contains 16 pieces, 1 fuse (capsule); Every 4g/ bottle× 6 bottles/box×100 boxes/box.
Store in a cool and dry place and keep it sealed.
Valid for 4 years; 5 years (capsule)
Approval number: National Medicine Zhunzi Z53020799
Features:
1, hemostasis: Yunnan Baiyao can significantly shorten the coagulation time of rabbits and humans, shorten the prothrombin time of rabbits, shorten the bleeding time of rats, and resist the anticoagulant effects of heparin and dicoumarin. Its coagulation mechanism is to increase the permeability of platelet membrane and cause the release of platelet components, including adenosine and calcium, similar to thrombin-induced platelet reaction. Its hemostatic effect mainly comes from the effective components in drugs, and has nothing to do with its pH and vasoconstriction.
2. Promoting blood circulation and removing blood stasis: Yunnan Baiyao can obviously improve the microvascular circulation disorder caused by dextran, obviously reduce the thrombosis caused by ligation of inferior vena cava in rats, and reduce the weight of thrombus, which is significantly different from the control group. (P & lt0.0 1)
3, anti-inflammatory; Subcutaneous injection of Yunnan Baiyao total saponins has inhibitory effects on adjuvant polyarthritis, paw swelling caused by carrageenan, leukocyte chemical inflammation model and cotton granuloma in rats. On the one hand, its anti-inflammatory mechanism can inhibit the release of inflammatory mediators histamine and prostaglandin E, and resist the joint swelling and capillary permeability caused by them, on the other hand, it can be produced by promoting the secretion of corticosteroids.
4. Increase the myocardial nutritional blood volume: The myocardial nutritional blood volume of mice was measured by the isotope 8bRB, and it was found that Yunnan Baiyao could obviously increase the myocardial nutritional blood volume, and the effect was the strongest after 30 minutes.
5. Increase the immune function of the body: Yunnan Baiyao can significantly increase the radioactivity in the liver gland of mice, that is, increase the phagocytosis of liver and spleen, as determined by radioactive colloid.
6. Anti-cancer: Two saponins I and VI isolated from Yunnan Baiyao showed certain anti-cancer activities in the screening tests of P-388, L-1210+00 and 9KB tissue culture systems.