Foreign NameRecombinat Human GM-CSF, GM-CSF. rhGM-CSF, Levcomax, Sargramostim,Molgrastim
Indications
This product is indicated for the treatment of leukopenia caused by cancer chemotherapy and myelosuppressive therapy, and for the treatment of low white blood cell counts in patients with bone marrow failure, and for the prevention of infectious complications which may be potentially present in the presence of leukopenia. It can also be used to prevent the complications of infections that may be associated with leukopenia, and to accelerate recovery from infection-induced neutropenia
Dosage and Administration
This product is a sterile, dry, frozen powder that is dissolved in a dilute solution and injected either intravenously or subcutaneously. The dose depends on the specific condition, and should be adjusted to maintain the leukocytometer at the desired level, usually below the 9th power of 10/L. In myelodysplastic syndromes, aplastic anemia with leukopenia, a dose of 3 μg per kilogram of body weight should be administered subcutaneously once daily. In cancer chemotherapy-induced leukopenia, the dose is 5-10 μg per kilogram of body weight, injected subcutaneously once daily. It can be used only 1 day after the cessation of chemotherapy for 7-10 days. For bone marrow transplantation, 5-10 μg per kilogram of body weight per day, 4-6h IV, once daily.
Precautions
1. Common adverse reactions are fever, rash. Less common are hypotension, nausea, edema, chest pain, bone pain and diarrhea. Rare reactions are anaphylaxis, bronchospasm, heart failure, supraventricular arrhythmias, cerebrovascular disease, confusion, convulsions, dyspnea, pulmonary edema and syncope. Occasionally, low serum albumin level. 2. It is contraindicated in patients with a history of hypersensitivity to the product and in patients with autoimmune thrombocytopenic purpura. 3. Pregnant women should not use, nursing women should stop breastfeeding.
Specifications Lyophilized powder injection: 150μg (1.67×10^6μ) vials, 300μg (3.3×10^6μ)/vials, 700μg,
50μg,100μg,250μg,400μg.
The product should be used in patients with history of allergy and patients with autoimmune thrombocytopenic purpura.