Part one of the drug factory internship summary report
I. Mintai Pharmaceuticals corporate profile.xx Pharmaceutical Co., Ltd. formerly known as xx Pharmaceutical Eight Factory, was founded in 1987, the factory is located in the beautiful scenery, surrounded by mountains at the foot of Changbai Mountain, xx Industrial Park. The company covers an area of 50,000 square meters, with a building area of 20,000 square meters. It has four production lines for pre-treatment and extraction of traditional Chinese medicines, tablets, capsules and granules, as well as a quality inspection center with complete facilities and advanced instruments. The company has 560 employees, including 128 professional and technical personnel, with intermediate or above professional and technical titles accounted for 30% of the total number of employees. Mintai Pharmaceutical Factory has now become a modern pharmaceutical enterprise integrating scientific research, development, production and sales. Business philosophy: focus all resources, in-depth research in related fields, professional innovation, professional services.
Second, the internship tasks.
At first, it was in the production workshop, and then it was transferred to the laboratory, mainly learning how to identify drugs, test the qualification of drugs, and microbial limit check.
Third, the content of the internship.
Preparation of silica gel plates, one part of the stationary phase and three parts of water in a mortar and pestle grinding and mixing, poured into the applicator, smooth movement of the applicator on a glass plate for coating, sun-drying, activation at 105% for 30 minutes, standby. Determination of loss of weight on drying of the drug Weigh 1 gram of the drug, place in a weighing flask and dry at 105 degrees Celsius until constant weight is reached, the loss of weight should not be more than 10%. Determination of disintegration time limit of the drug using disintegrometer, electronic balance etc. Microbial limit check.
(1) Sterilize all utensils, pipette, flat dish wrapped in kraft paper, at 165 degrees Celsius, autoclaved for 4 hours, remove, standby.
(2) before doing the experiment, the application of Suhr disinfectant solution on the operating table for disinfection, ventilation, ultraviolet sterilization, wash your hands with hand sanitizer, the required items through the transfer window into the bacteriological examination room for the experiment, the operation of the operation should be wearing a clean clothes, masks and gloves, each sample at least the preparation of more than two petri dishes.
(3) Preparation of test samples PH7 sodium chloride - peptone buffer, take dipotassium hydrogen phosphate, sodium hydrogen phosphate, sodium chloride, peptone, liquid samples need 90 ml solid samples need 100 ml. The medium, nutrient agar medium, tiger red agar medium, put about 15 ml in each flat dish. When the configuration is complete, place it in a sterilizer and sterilize, 121 degrees Celsius for 15 minutes. Place in the refrigerator and store frozen.
(4) herbs containing animal tissues, should do a salmonella check, 10 grams of powdered medicine poured into 200 ml of nutrient broth medium, shaking well, put into the bacterial incubator, 18 to 24 hours, remove, suck out a milliliter, put into the bright green, cultivation, the next day, will be taken out, with inoculation loop inoculation in bile salts, sulfur milk, MacConkey agar medium, cultivation for a day to see the results.
(5) learn how to determine and use the suspended particle dust detector, and the determination of purified water.
Fourth, the internship perception.
During the internship, I fully utilize the knowledge learned in school to improve their skills, just graduated from the students and employed in the post for many years compared to the old staff, both in terms of skills, or in the experience are far inferior to them, I think that the knowledge of the books is certainly important, but the school should let the students more contact with some of the practice, so that the internship in order to give the company to leave a very good impression, so that we grow up to be a very good person, so that we have a very good impression of the company. In my opinion, book knowledge is important, but the school should let students have more practice, so that they can leave a good impression on the company during the internship. But the internship is also many shortcomings, for example, students in the school when the living environment, lifestyle and philosophy, are very different from the community, and this only eight months of internship can not be completely transformed into a real staff, so in the future, no matter where the work, the body and mind should be integrated into the community, and the complete integration of a member of the community.
V. Suggestions for internship.
Part II Pharmaceutical Internship Summary Report
In the first half of the month, I used this time in the xx Pharmaceuticals for three days of observation and practice internship activities, and learned a lot of knowledge.The purpose of the practice:
By visiting and experiencing the production process of the chemical plant workshop, linked to their academic knowledge, for future employment to understand the situation.
Practical content:
Visiting the workshop of ethylene oxide production, consulting engineers, technicians, workers and so on, and linking the knowledge learned in school with the actual life production.
I. Introduction of xx Pharmaceuticals Co.
xx Pharmaceuticals is a large-scale pharmaceutical and chemical enterprise integrating science, industry and trade, mainly engaged in the production of pharmaceutical raw materials and intermediates, food additives, daily-use chemical products and medical devices, the development and transfer of new pharmaceutical products and technologies, as well as the production and sale of fine chemical products and other four major product lines: the production of ethylene oxide, the production of ethylene oxide, the production of ethylene oxide, the production of ethylene oxide, the production of ethylene oxide, and the production of fine chemical products. The production of ethylene oxide, pharmaceutical intermediates series with sodium taurate and other products, medical equipment series with traditional Chinese medicine decoction machine and daily-use chemical surfactants series with sodium coco hydroxyethyl sulfonate. Among them, the annual output of 1000 tons of taurine, quality standards using jp8, vsp26, 80% of the products are exported to Europe and the United States, South Korea and Southeast Asia.
In recent years, XX Pharmaceuticals continues to innovate and develop rapidly, and has become a key backbone enterprise in XX County, and has been recognized as a major contributor to the tax revenue of XX County year after year.
Second, the main body of the report
1, the chemical principle
Ethylene oxide, a colorless gas at room temperature, low temperature for colorless liquid flow. Ethylene oxide is a colorless gas at room temperature and a colorless liquid at low temperature. It has an ether odor and is toxic. Colorless gas at room temperature, colorless liquid at low temperature. There are two methods of production: the first is ethylene oxidation and the second is chloroethanol dechlorination. The plant has adopted the first method, i.e. oxidation method, where ethylene and peroxide act and peroxide makes the double bond of ethylene to undergo affinity addition so as to produce ethylene oxide. Because ethylene, peroxide, ethylene oxide are flammable and explosive, for safety reasons so there is no actual operation of the workshop equipment.
2, the production of raw materials
Due to xx bordering Wuhan, Wuhan ethylene project is currently the central region of the petrochemical project, and in Wuhan production of peroxide manufacturers, so the production of raw material sources are more adequate.
3, the production process
The powdered peroxide into the various parts of the reactor, to the reactor into a large number of ethylene gas, the reaction temperature is controlled at low temperatures, generally in -10 to 20 ℃. One can make ethylene oxide liquefaction is conducive to the collection, the second is according to the principle of Le Chatelier to generate the liquid phase is conducive to the yield, the third is to avoid the high temperature side reaction more, the fourth is to avoid the temperature is too high explosion.
4, ethylene oxide loading
Ethylene oxide is a flammable and explosive, prone to polymerization of chemical substances, in the air at 1 atmospheric pressure under the conditions of the explosion limit of 3% -100% volume percent concentration, so the storage and transportation of ethylene oxide is very strict requirements, generally using nitrogen Sealed. The use of specialized ethylene oxide car tanker transportation.
Third, the summary
In this holiday, I went to the workshop of the internship practice, so that I have grown knowledge and insight, but also let me grow a lot of practical knowledge, very rewarding, but also very touching. In a few days of activities, I strengthened at least one point of view - the development of the economy to have a long-term vision, knowledge, but also technology. This internship has also strengthened my belief that I need to work hard to learn knowledge and skills to contribute to the future development of China's economy.
Part III Summary Report of Pharmaceutical Internship
I. Purpose of the internship1. Through visiting and studying in the workshop of the pharmaceutical factory, I understand some basic equipment of the workshop, the layout of the workshop and so on.
2. Listen to the relevant management and technical personnel, so that we have a basic impression of the pharmaceutical company.
3. For the work of the pharmaceutical factory and the production process of drugs have a visual understanding of the pharmaceutical process and the related process of machinery and equipment;
4. To help combine the theory of the school with the practice of the specific application of the knowledge of the profession in the reality of social work, deepen the understanding of theoretical knowledge.
5. The pharmaceutical internship in advance of the future may work in the environment has a comprehensive understanding of the future employment positions in the future to find a suitable position, clear future employment routes, to enter the community how to apply professional knowledge to the actual production and life to have a certain understanding.
Second, the internship unit profile
xx Pharmaceutical Factory is a national key secondary schools in Hubei Province, Hubei Province, the combination of production and operation functions and training teaching function of the school-run industry, for Huazhong University of Science and Technology, Tongji School of Pharmacy and Hubei University of Technology, teaching practice base. Its tablets, capsules, granules have passed the GMP certification of the national organization, and in February 2002, it obtained the GMP certificate issued by the former State Drug Administration. At present, it can produce tablets, hard capsules and granules in three dosage forms of 12 varieties of preparations, with an annual production capacity of 200 million tablets, 50 million capsules and 15 million bags of granules, which can accommodate 50 students at a time for production training.
Third, the content of the internship
1, visit the production workshop of the pharmaceutical plant
(1) to understand the layout of the plant and the workshop
x month x day we came to the xx pharmaceutical plant by car, in the leadership of the plant under the leadership of the pharmaceutical plant, we began the internship of the pharmaceutical plant. First of all, the leadership of the pharmaceutical plant introduced us to the layout of the Yikang Pharmaceutical Plant and the layout of the workshop allocation, the workshop in accordance with a certain process layout, in order to achieve the purpose of convenience and efficiency. xx Pharmaceutical Plant for the convenience of students internship, several important workshops are distributed in the corridor side, in order to facilitate students to observe, study.
(2) Familiarize yourself with the drug production process
Under the leadership of the relevant leaders of the pharmaceutical plant, each of our students put on shoe covers and formally entered the drug production work area of XX Pharmaceutical Plant. xx Pharmaceutical Plant strictly implements the principle of separating the flow of people and the flow of goods in order to ensure that the drugs are sterile, and in some special pharmaceutical workshops, the workers are also required to wear special sterile work clothes. In the entire pharmaceutical workshop, all staff must wear white coats, with a good working cap, and the items in the elevator transported to the second floor of the pharmaceutical workshop, must undergo a strict sterilization work to ensure that each process.
2, visit the pharmaceutical quality inspection department
Pharmaceutical quality inspection department in another building on the second floor, the quality inspection department is divided into drug sampling room, drug testing room, microbiology testing room and so on. The quality control department also has a lot of instruments for testing drugs, such as: high performance liquid chromatography, dissolution of the instrument, disintegration meter, tablet press and so on.
Fourth, the internship results and feelings
Although the internship is over, but this experience has a great impact on me and education. Internship is a practical means for us to improve our cognition. Because of the visit to the internship time is relatively tight, we can only briefly understand the general structure of the drug production and packaging plant and the basic process, roughly know how the real drug production is a matter of fact, but also so that the knowledge learned from books to materialize, visualization of some of the first-hand experience of the pharmaceutical workshop on the strict requirements of hygiene, the staff of the rigorous work attitude, so that students have a new understanding and understanding of their own and their own profession. The students have a new knowledge and understanding of themselves and their own profession. It not only makes me in the theory of pharmaceutical technology in this field has a new familiarity, but also more let me feel the importance of the combination of theory and reality, growth of insight, open up the vision.