[1] Process simulation of micro-nano medical devices. Based on the atomic model of the dynamics of Monte Carlo, metacellular automata and other methods to carry out complex three-dimensional microstructure-oriented composite machining process simulation computational and experimental research. The contents include the surface morphology formation mechanism and quality control of body micromachining of micro-nano medical devices, the role and interpretation of surfactants in reactive ion processing, thin film deposition and etching. This direction will explore new processes and methods for micro- and nano-medical devices, study the mechanism of micro- and nanofabrication methods and their multi-scale simulation models, and develop design tools and system integration technologies for micro- and nano-medical devices.
[2] Measurement of micro-nano hydrodynamic parameters. In biomedical testing, most of the non-contact mode atomic force microscopy (AFM) to measure, in order to effectively improve the stability of the AFM in non-contact mode probe control system, research active probe need to build biomedical samples of the sensing and detection of the environment, probe drive control system, probe amplitude sensing system, and the probe resonance factor measurement system; the design of universal non-contact type atomic force microscope suitable for air, aqueous solutions and vacuum A generalized non-contact AFM system for air, aqueous solution and vacuum is designed. The system is used to detect the force between biomolecules and fluid molecules, to evaluate the performance of single-molecule fluid sensors, and to observe and analyze nano-materials, nano-films, and microfluidic chips.
[3] Manufacturing platform for micro and nano medical devices. (1) Taking microfluidic chip as the research object, based on the concept of "micro total analysis system", we study the mechanism and method of rapid calibration, separation and isolation of biological cells in whole blood samples through dielectrophoresis, and automatically detect and analyze the target cells, so as to put forward a set of practicable process methods and theoretical models. (2) Taking single-molecule sensors as the object of research, we study the fabrication process of nano-channels, including nanowire template process and electron-beam lithography process, and design and fabricate field-effect tube-based nano-channel single-molecule sensors.
[4] Manufacturing platform for micro-nano medical devices. Take minimally invasive medical vascular stents as the research object, study the processing process and mechanism of femtosecond laser, build a femtosecond laser processing platform; use femtosecond laser to process drug-carrying vascular stents, and study the mechanism of energy transfer in the process of femtosecond laser processing; through the study of the processing mechanism, drive the discipline of mechanical manufacturing to the direction of advanced manufacturing, extreme manufacturing, and promote the level of application of micronanufacturing in the processing of medical devices.
[5] Nanosimulation of micro-nano medical devices. This lab will carry out the basic theoretical research work on molecular dynamics, ab initio molecular dynamics, Monte Carlo, numerical algorithms, and numerical simulation work on low-dimensional structures, micro-nano-fluids, solid-liquid interfaces, and microscale heat transfer based on the cluster of parallel machines; carry out the molecular dynamics simulation of protein transport in the nanochannels; and study the nanochannel size less than the thickness of the bilayer based on the continuum theory of the Poisson- Boltzmann equation and the adaptation of Navier-Stokes equation when the size of the nano-channel is smaller than the thickness of the bilayer.
[6] Theory of micro and nano medical device design. At the micro and nano scale, the mechanical properties of materials such as elastic modulus, fracture strength and inter-surface friction are very different from the macroscopic ones due to the influence of scale effect and surface effect. Understanding the mechanical behavior of micro and nanomaterials and structures is necessary for the design optimization of micro and nanomedical devices, and the related research is a cutting-edge issue of concern to both the theoretical and engineering communities***, and is the basis for the development of the discipline of micro and nanoscale mechanics. This laboratory will be engaged in the M/NEMS standard parts library, standard machining process aspects of modeling and collation, for the micro-nano manufacturing industry; in the purchase of a number of commercial design software, based on the secondary development of the design software, research and development of a number of micro-nano medical device design software with independent copyright.