Pharmaceutical freeze dryer, also known as pharmaceutical freeze dryer, is applied to biological products, pharmaceutical industry freeze drying equipment, the earliest penicillin is the use of pharmaceutical freeze dryer vacuum freeze drying technology purification and separation, if there is no vacuum freeze drying technology, penicillin, including a lot of other drugs are still asleep.
Two, pharmaceutical freeze dryer can be used to freeze dry which drugs
Many drugs are more susceptible to temperature and moisture content, the presence of large amounts of water is easy to decomposition, inactivation, and transportation is not convenient, with pharmaceutical freeze dryer, can produce a stable structure, biological activity is basically unchanged, the volatile components of the drug and the loss of heat-induced volatility of the components of the drug loss is small, the main application in the It is mainly used in the production of various drugs, such as various antibiotics, vaccines, enzyme preparations, plasma, traditional Chinese medicine injections, biological products, genetic engineering products, medical products and so on.
In addition, the use of pharmaceutical lyophilizers can make some injections become dry blocks, which are easy to transport, prolong the effective preservation period, increase the drug loading capacity, and improve the quality of drugs.
Three, the use of pharmaceutical freeze-drying machine points have what
Pharmaceutical freeze-drying machine and the use of ordinary freeze-drying machine is almost the same, but in the use of the process, should pay attention to the following points:
1, prohibit the use of pipe as a load-bearing escalator.
2, before the operation of the equipment, please operator carefully read the instruction manual, after training and qualified before the operation of the machine.
3, the random computer as a special computer for machine operation, prohibit the installation of other software, prohibit the connection with other mobile hardware devices to prevent the invasion of computer viruses.
4, when the overall rise of the plate layer, the plate layer under the bracket and the bottom of the box better not exceed 500mm, so as to avoid the metal hose is pulled bad.
5, in the use of jacket cooling water cooling, please ensure that the water in the jacket to be discharged to prevent the water in the jacket to freeze into ice will be jacket freeze cracks; requirements for the drainage must be the jacket bleeder valve open, and it is recommended that the drain valve has been in the state of normally open.
6, before the pressure plug operation, it must be ensured that the vials are evenly distributed throughout each plate layer. If the vials are not evenly distributed across the plates, there is a risk of crushing the vials during the stoppering operation. If the vials are not sufficient to cover the entire plate layer, it is also important to ensure that the vials are evenly distributed across the plate layer.
7. The sterile filter may be in an over or under pressure state and should not be disassembled while the equipment is in use.
8, when it is necessary to leak detection of the system concerned, it is recommended to use nitrogen pressure, do not use other gases to avoid danger.
9, in the lyophilizer or near any welding operation, please cut off the power supply to the PLC and all electronic equipment to ensure that the welding arc interference will not cause damage to electronic equipment.
10, control the cylinder hydraulic working safety pressure: plate lifting cylinder working pressure: 20 ~ 80bar; mushroom valve cylinder working pressure: 20 ~ 60bar; cylinder larger working pressure can not exceed 80bar. more than the above pressure operation, may cause damage to the machine, to contact the manufacturer in time.
11, before opening the door of the electrical cabinet, please make sure the total power supply is off. If the equipment is installed with UPS power supply, even if the main power switch of the electrical cabinet is turned off, there is still a danger of high voltage electricity.
12, in order to protect the normal operation of the freeze dryer, we recommend to run the freeze dryer in the environmental conditions below 32 ℃.
13, in the machine handling or positioning process, you must grasp the machine to prevent the machine from tipping.