Pharmaceuticals are special commodities used for the prevention and treatment of diseases and for the restoration and adjustment of the functions of the organism, and its quality is directly related to the health and well-being of human beings. If some medicines are contaminated by microorganisms, dust particles and other contaminants or cross-contaminated during the manufacturing process, they may produce unanticipated diseases and hazards.
2, medical applications and medical research in the clean room requirements
And in medicine, more biological clean room for microbial contamination control. In biological clean room, these microorganisms are mostly composed of bacteria and fungi, particle size size above 0.2um, common bacteria particle size are above 0.5um, and most of them are attached to other material particles. Biological pollution channels not only through the air, but also with the human body, with the operator's clothing.
In the field of medical research, biological laboratories, aseptic laboratories, and for biochemical and medical experiments with "special breeding animals" breeding room are also very important to control microbial contamination.
3, precision machinery and fine chemical products production of clean room requirements
With the development of science and technology, the production of many industrial products on the production environment of the dust concentration of extremely high requirements, which requires its production environment with a certain level of air cleanliness and control of the production process required for the supply of various types of related substances quality. For example, in the production of film, film, if contaminated by dust, will occur in the emulsion oxidation, weakening of activity, pH changes, etc., thus affecting the film's photographic properties.
4, semiconductor, integrated circuit production of clean room requirements
Semiconductor material purification as an important basis for the development of semiconductor devices. Due to large-scale and ultra-large-scale integrated circuit process requirements, in order to obtain high-purity silicon materials, raw materials and intermediate media of high purity and cleanliness of the production environment has become a prominent issue affecting product quality.
The yield of integrated circuit chips is related to the defect density of the chip, which is related to the number of particles in the air. Therefore, the rapid development of integrated circuits, not only on the air to control the size of the particles have very high requirements, but also need to further control the number of particles; at the same time, for the production of ultra-large-scale integrated circuits in the environment of the control of chemical contamination is also related to the requirements.
5, cosmetics, food production of clean room requirements
Most of the modern cosmetics contain proteins, vitamins, amino acids, plant extracts, etc., these components for bacteria, mold and other microorganisms breeding, reproduction provides favorable conditions. Therefore, microbial contamination is an important factor affecting the quality of cosmetics. The control object of the clean room used in the cosmetic production process is mainly dust particles and microorganisms, which is similar to the requirements of the clean room used for pharmaceutical production. At present, the air cleanliness level of the clean room for cosmetic production can be referred to the GMP specification for pharmaceuticals.
In the production process of food factories, the strict management of facilities is to ensure food safety and hygiene, to prevent the occurrence of pathogenic coliform bacteria, salmonella caused by food poisoning or drinks mixed with mold, etc. In the 1990s to the present, the WHO and a number of developed countries to introduce the HACCP (Hazard Analysis and Critical Control Points) system, the development of the use of hygiene management of production processes. The food production recognition system.