① use of dosage tanks or other containers, transfer pumps and other equipment or utensils to prepare the media required by the process;
② the use of sterilizer or sterilizer, such as disinfection of the media, compressed air or other materials, equipment, utensils, etc., disinfection, sterilization;
3 microbiological methods of cultivation, the preparation of all levels of production of strains, re-strengthening, selection of high-quality and high-yield production of bacteria strains;
④ Operate fermentation equipment and control instruments and meters, adjust fermentation process conditions appropriately according to fermentation metabolism indexes, and complete the fermentation process;
⑤ Add instrumental enzymes and intermediates, and control the process conditions, and complete the enzymatic and conversion process of antibiotics;
⑥ Use solid-liquid separation equipment for solid-liquid separation of fermentation broth or leaching tuck;
⑦ Use of solvents, Exchange resin for the extraction of active pharmaceutical ingredients, purification;
8 the use of sterilization, filtration, crystallization, drying and other methods for the purification of drugs;
9 the use of scales will be packaged according to the specified amount of raw materials in special packaging containers;
⑩ preparation of raw materials in line with the standards for the production of process water and so on.