First of all, do you have any fighting skills?
If you don't have a fighting foundation, it is recommended to hit near the ribs, or hit the armpits near the acupoints, if you hit the right one, you can punch it for a short time to make it difficult to breathe, and will not cause too much damage, or hit the joints, breaking joints and so on.
If the opposite hand with a weapon, it is recommended to escape, confident can be folded back to run plus positive stirrups side kicks, etc.
If the opposite hand with a weapon, it is recommended to escape.