Analysis of the importance of internal work in the enterprise management system Paper

Abstract: In the current world economy and the development of China's pharmaceutical market, in recent years, China's pharmaceutical business enterprises are undergoing radical changes, drug storage and maintenance quality management, is an important part of the quality management of the pharmaceutical business process, which plays an important role in ensuring the quality of drugs. The quality of drug storage and maintenance work directly affects the quality of drugs. In practice, it must be equipped with conditions that meet the requirements of drug storage to achieve the requirements of controlling the quality of drugs. Keywords drug storage, influencing factors, classification storage, drug maintenance, special drugs Introduction The quality management of drug storage and maintenance is an important part of quality management in the process of drug operation, which plays an important role in ensuring the quality of drugs. The quality of drug storage and maintenance work directly affects the quality of drugs. In practice, it must be equipped with conditions that meet the requirements of drug storage to achieve the requirements of controlling the quality of drugs. Classification of drugs storage management of drug storage is the basic principle of classification of storage, classification of storage is based on the quality characteristics of drugs and storage requirements, according to the different natural attributes of drugs, conservation measures, fire fighting methods of consistency will be divided into a number of categories of drugs in order to be separately stored in different warehouses, and according to the district, row number of scientific storage. II. Influencing factors on the quality of drug storage (a) environmental factors: daylight The ultraviolet rays in daylight play a catalytic role in drug changes, accelerating the oxidation and decomposition of drugs. Air Oxygen and carbon dioxide in the air have a greater impact on the quality of drugs. Oxygen is easy to oxidize some drugs and deteriorate. Carbon dioxide is absorbed by the drug, carbonation and deterioration of drugs. Humidity The amount of water vapor in the air is called humidity. Humidity is too large to make the drug deliquescence, liquefaction, deterioration or mildew, humidity is too small, but also easy to make some drugs weathering. Weathering of drugs, its chemical properties generally did not change, but in the use of the dose is difficult to grasp, especially highly toxic drugs, may be more than the dosage and cause accidents. Easy weathering of drugs are atropine sulfate, codeine sulfate, magnesium sulfate, sodium sulfate and alum. Most of the drugs can absorb water vapor in the air and induce moisture when the humidity is high. As a result, the drug dilution, deliquescence, deformation, mold and so on. Easy to attract moisture of the drugs are pepsin, glycerin, etc.. Temperature Too high or too low temperature can make the drugs deteriorate. The temperature is too high with the volatile degree of drugs, form and cause oxidation, hydrolysis and other changes and the growth of microorganisms have a great relationship. Too low a temperature and easy to cause freezing or precipitation. Time Some drugs are unstable because of their nature or potency, although the storage conditions are appropriate, too long will gradually deteriorate and become ineffective. (b) Human factors: personnel settings; drug quality supervision and management, such as drug quality supervision and management of the establishment of rules and regulations, implementation and supervision and management of the status of drug quality; drug storage and maintenance skills of pharmacy personnel, as well as the degree of importance of the quality of medicines, the responsibility of the strength of the physical conditions, the mental state of the good and bad, and so on. (C) the drug itself factors: hydrolysis is the main pathway of drug degradation, belonging to this type of degradation of drugs are mainly esters (including lactones), amides (including lactones). Oxidation is also the most common reaction of drug deterioration. Drugs with the structure of phenols, enols, aromatic amines, pyrazolones, thiazines are easier to oxidize. When drugs oxidize, not only is there a loss of potency, but color or precipitation may occur. Drugs that are easily oxidized should pay special attention to the effects of light, oxygen and metal ions on them. The packaging materials of drugs also have a greater impact on the quality of drugs. (D) Appearance inspection of drugs Inspection content: The traits of drugs, including form, color, smell, taste, solubility, etc. are important contents of the appearance quality inspection of drugs. The inspection contents of different dosage forms of drugs are different. Tablets: Consistent shape, uniform color, smooth surface, no roughness and porous phenomenon; no adherence to fine powder, particles; no impurities, dirt; uniform color of the coating, no color spots, and uniform thickness, smooth surface, after breaking the coating, the core of the tablet particles should be uniform, uniform color distribution, no impurities, the hardness of the tablets should be moderate, no abrasion, chalking, debris and hardness phenomenon, and the smell, taste, in line with the specific physical properties of the drug. Physical properties. III. Classification and storage management of drugs (a) according to the category of drugs, dosage form classification and storage According to the category of drugs are generally divided into chemical drugs (raw materials and their preparations library), proprietary drug library, Chinese medicine library, Chinese herbal medicine library, etc. According to the dosage form of drugs are generally divided into injections, tablets, capsules, tinctures, syrup, ointment library, powder library, etc.. (B) according to the classification of storage conditions for each type of drugs should be stored according to its storage temperature requirements were stored in cold storage (2 ~ C - l0 ℃), cool library (not higher than 20 ℃) or room temperature library (0 ℃ 30 ℃) the relative humidity of the library should be maintained between 45% to 75%, should also be based on the storage conditions of other requirements, pay attention to the storage of light. (C) according to the nature of the drugs categorized storage of all kinds of drugs in the buyer, the packaging are indicated on the storage method, with the use of the expiration date are indicated. For example: shading refers to the use of opaque containers, can be used brown containers or black paper wrapped in colorless transparent, translucent containers, airtight means that the container is sealed to prevent dust and foreign objects into the air, sealing refers to the container is sealed to prevent weathering, moisture absorption, volatilization, or foreign objects into the air, fusion sealing or sealing tightly refers to sealing the container or sealing tightly with the appropriate materials to prevent the invasion of air and water, and prevent contamination, the cool place Is not more than 20 ~ C, cold refers to 2 ℃ ~ l0 ℃, cool dark place is to avoid light and not more than 20 ℃, relative humidity is generally controlled between 60-70%, if the drug packaging or instructions do not specify the storage method on the storage at room temperature (& lt; 30 ℃) can be, in general, most of the drugs in the 2 ~ C or more, the lower the temperature conditions The lower the temperature, the better the quality of the drugs stored. (D) according to the natural properties of drugs classified storage of drugs for internal use and external use of drugs to be stored in separate libraries or graded, easy to crosstalk or the nature of the drugs affected by each other should be stored in separate libraries, the name or packaging of the drugs can be easily confused, should be divided into districts or palletized storage, narcotic drugs. A class of psychotropic drugs can be stored in the same special warehouse or special cabinet, medical toxic drugs should be stored in a special cabinet. Chinese herbal medicines, Chinese herbal medicines should be stored in separate warehouses with other medicines. (E) drug storage storage of drugs should be in accordance with the order of the drug production lot number or date of production in order to layer or separate stacking, according to the lot number or validity of the near and far stacking, to facilitate the first out of the first production, the recent first, in addition to the drugs should not be inverted when stacking, should be gently, lightly, and prohibited forceful collision. (F) color-coded management of the storage of drugs should be implemented color-coded management, the unified standard is to be examined and returned drugs library for the yellow library, qualified drugs library, zero weighing library and to be sent to the library for the green library of drugs, unqualified drugs library for the red. (G) unqualified drugs unqualified drugs should be stored separately, special account records, and have a clear sign.

(viii) the validity of the storage management of the implementation of the validity of the storage management of drugs, the validity of less than six months of drugs should be called for sale on a monthly basis. IV. Quality management of drug maintenance Drug maintenance is based on the law of change of drugs in the storage process, with the maintenance of drug quality of the relevant theories, methods and techniques, the quality of drugs for scientific maintenance of technical work, is the study of the law of change of the quality of the stored drugs and scientific conservation methods of a science. (A) the main responsibilities of drug maintenance work 1, the physical and chemical properties of drugs and storage conditions of the provisions of the reasonable storage of drugs storage and maintenance personnel should do a good job of temperature and humidity monitoring and management of the warehouse, strict control of temperature and humidity of the warehouse, to prevent the deterioration of medicines, to do a reasonable placement of the temperature and humidity meter, which can objectively reflect the temperature of the warehouse, humidity of the location, and the daily morning and afternoon of each time to record, if the temperature and humidity warehouse exceed the prescribed range, the temperature and humidity, and if the temperature and humidity warehouse exceeded the prescribed range, the temperature and humidity, and if the temperature and humidity warehouse exceeded the prescribed range. If the warehouse temperature, humidity exceeds the prescribed range, should immediately take control measures (humidity, cooling, warming, etc.) to restore it to the prescribed range, and make a good record. 2, the warehouse drugs should be based on the flow of regular maintenance and inspection, generally on the warehouse drugs monthly inventory, inventory, but also to check the quality of the drugs and expiration date. And do a good job of registering, especially for the validity of short time and easy to change the species should be appropriate to increase the number of inspections, if found in the stockpile maintenance of drugs of doubtful quality should be hanging a clear sign (yellow card), to be examined and suspended shipments, and at the same time fill in the quality of the drug quality inspection notification form to report to the quality management organization or the person in charge of the timely processing. Chinese herbal medicine or Chinese medicine tablets according to their characteristics, take drying oxygen, fumigation and other methods of conservation. 3, to regularly summarize, analyze and report the conservation check near the expiration date or longer in the library storage of drugs and other quality information. To establish drug maintenance files, including: detailed records of incoming and outgoing drugs, drug maintenance file form, maintenance records, test report query letter, quality report form, accounts, etc., responsible for the maintenance of the management of equipment and equipment, and regular inspections, maintenance and the establishment of the file, the expiration date of the drug refers to the drug in the specified storage conditions, to maintain its quality of the period of time, the state drug regulatory authorities According to the newly amended "Drug Administration Law", all the drugs produced and marketed for sale after December 1, 2001 must be marked with the expiration date, and drugs without the expiration date shall not be produced or sold, and the drug business units shall strictly implement the system of drug reminder of the expiration date, and the custodian of the storehouse shall fill in the "expiration date drug registry" on a monthly basis. Unit when the drugs from the expiration date of only 3 months to the expiration date of the drugs within the scope of the call, if it is estimated that can not be expected to sell out, should be promptly contact with the supply unit to avoid the loss of expiration date in the library of the return of goods. (B) key conservation varieties 1, the establishment of key conservation varieties table for the drug properties of unstable drugs, drugs stored for a longer period of time, near the expiration date of the drugs, drugs with special storage requirements, there has been a quality problem of drugs adjacent to the batch number of drugs. Chinese medicine tablets in the perishable varieties. Such as easy to moth, easy to mold, easy to absorb moisture, easy to flood the oil varieties, in the storage process should be treated specially, the establishment of key conservation varieties table. 2, the key conservation content of the inspection and control of conservation of the storage conditions of the drugs, the drugs for regular quality checks, the problems found in a timely manner to take effective measures to deal with. 3, conservation of the duties and responsibilities of the division of labor, first of all, the quality management personnel are responsible for the conservation of medicines for the staff to carry out business First of all, the quality management personnel is responsible for providing operational guidance to the drug maintenance staff, finalizing the maintenance work plan, determining the key maintenance varieties, analyzing the quality problems reported by the drug maintenance personnel and determining the treatment measures, and supervising and managing the implementation of the maintenance work. Secondly, the warehouse custodian is responsible for the reasonable storage of medicines in the warehouse, managing the storage conditions such as temperature and humidity in the warehouse, filling in the "nearly expiration date medicines reminder form" on a monthly basis, and assisting the conservation staff to carry out the specific operation of the conservation of medicines. Finally, the maintenance personnel are responsible for guiding the custodians to carry out reasonable storage of drugs, regularly checking the storage conditions of the drugs in the warehouse and the quality of the drugs in stock, and adopting scientific and effective maintenance methods according to the storage characteristics of the drugs. Regularly summarize, analyze and report the quality of product maintenance information, responsible for acceptance of the management of maintenance and storage equipment, the establishment of drug maintenance files. 4, drug maintenance files to establish drug maintenance files, refers to the characteristics of the maintenance of species, the establishment of a certain business cycle, the stability of the quality of the drug stored in the monitoring, summarize the conservation experience, improve the conservation methods, and the accumulation of technical information on the accumulation of a means of management. It has the following contents: basic quality information of drugs. Observe the tracking records of the storage quality of drugs within the cycle, the handling of the problem; maintenance quality information, drug conservation personnel regularly summarize, analyze, and report the contents of the maintenance inspection, the near expiration date or the quality of long-stored drugs information, rational regulation of the number of drugs in stock. Ensure that the operating drugs meet the quality requirements. Quality management of drug maintenance drugs in the storage process by internal factors or external factors, quality changes will occur, so the maintenance of drugs is one of the main content of drug quality management, is the quality of drugs in circulation indispensable and important links. V. Management of special drugs (a) the management of unqualified drugs unqualified drugs management quality unqualified drugs include: intrinsic quality unqualified drugs and extrinsic quality unqualified drugs. In the acceptance of storage check out the unqualified drugs, the acceptance of personnel should be rejected and explain the reasons, such as the discovery of counterfeit drugs, inferior drugs or drugs with major quality problems, should be reported to the local drug supervision and management department, in the library of the maintenance of the unqualified drugs checked out should be filled out in a timely manner, "drug quality re-inspection of the single" reported to the drug management department and the leadership for approval! Confirmation of the sale to be dealt with, the emergence of unqualified drugs, should promptly identify the causes, on the basis of identifying the causes should be promptly dealt with and take effective preventive measures, if necessary, unqualified drugs to be destroyed, but to do a good job in advance to register, statements, explain the reasons approved by the leadership of the proper handling. (B) the management of special drugs, special drugs, the management of national narcotic drugs, psychotropic drugs, radiopharmaceuticals, toxic drugs for medical use, etc., the implementation of special management of special management of the purchase of drugs, acceptance into the warehouse, storage and custody, out of the warehouse to review, sales and other aspects of strengthening the management of narcotic drugs and a class of psychotropic drugs should be implemented in the exclusive custody, if necessary, the implementation of the double-locked custody system, the special cabinets should be security measures, such as Alarms, monitors, according to the nature of special drugs to determine the storage conditions, to set up a special account, a person to register. Regular inventory, so that the account matches the damaged, spoiled, expired, expired and can not be sold varieties should be counted and registered, separate and properly stored, reported to the drug supervision and management department for approval to deal with the treatment of the views on the archives for further investigation. Conclusion:To serve the people's health is our purpose, with the continuous development of the economy, social progress, people's living standards, the increasing demand for drugs, the quality of drugs is the most critical foundation. To create greater economic benefits for the enterprise must have good drug storage and maintenance, more thinking and learning, and constantly improve themselves! This paper combines some of the current methods and experiences of different aspects of the status quo, talked about their own views and opinions, and I hope that the future of drug storage and maintenance have a better help. Acknowledgement five years of campus life will soon come to an end, draw a period, the heart is endless reluctance and attachment. From here out, for my life, will be to embark on a new journey, to apply the knowledge learned to practical work. Looking back on five years, made some achievements, life has happiness and hardships. Thank you for the teacher for five years to my tireless teaching, care and love for my growth.

School friends, love as brothers and sisters. Four years of wind and rain, we walked together, full of love and care, leaving me the best memories worth treasuring. In my more than ten years of study, inseparable from the encouragement and support of parents, is their hard work, selfless pay, for me to create good learning conditions, I can successfully complete the completion of my studies, grateful to them has been on my upbringing and cultivation.

In the internship process, the unit leaders enthusiastic guidance and selfless help, so that I learned more practical knowledge in the society of this university, but also let me recognize the status of the pharmaceutical retail industry and the trend of the pharmaceutical industry, the real integration into the pharmaceutical industry. At the same time, I also got a lot of help and support from my colleagues, and I would like to express my heartfelt thanks! Finally, I would like to express my special thanks to Mr. Cai, who gave us great help and encouragement at the last moment of my graduation so that I could successfully complete my graduation design, and I would like to express my heartfelt gratitude. References: [1] Yang Baofeng. Pharmacology, Beijing: People's Health Publishing House, 9.005.410 [2] State Drug Administration Licensed Pharmacist Qualification Center Organization. Beijing: China Chinese Medicine Press, 2003. 242 [3] Xie Bin. Handbook of Practical New Drugs, Beijing: People's Health Publishing House, 2002. 140 [4] Zhou Haiyang, Wang Longxing, Sun Jiangchun, et al. Analysis of the role of "total control, structural adjustment" policy on the healthy development of the pharmaceutical industry [J]. Chinese Journal of Hospital Management, 1995, 11(9):534.[5] Zhu Huiying, Cao Hongtao. Han Liping, et al. Investigation and analysis of antimicrobial drug application in general hospitals and management countermeasures [J]. Chinese Journal of Hospital Infection, 2003, 13(2):152-155-[6]Xing Hongxia, Zhang Hongying, Zhang Jianping. Survey on the management of antimicrobial drug use in 18 hospitals in North China[J]. Chinese Journal of Hospital Infection, 2003, 13(9): 858-860.