Collagen is a structural protein in extracellular matrix, which contains one or more triple helix regions composed of α-chains.
Collagen accounts for 25%-30% of protein, and its weight is about 6% of body weight. Widely distributed in skin, tendons, ligaments and bones. At present, there are 27 kinds of collagen known, and the common types are I to V; Among them, type ⅰ is mainly distributed in tendons, bones and teeth, and type ⅱ is mainly distributed in cartilage and vitreous body; Type III is mainly distributed in the skin, cardiovascular system and dermis of infants. The preparation methods of collagen mainly include animal source extraction and genetic engineering preparation, both of which have their own advantages and disadvantages and are constantly improving; In March and April of 2002/KLOC-0, the Food and Drug Administration issued the Naming Guiding Principles of Recombinant Collagen Biomaterials and the Classification and Definition Principles of Recombinant Collagen Medical Products, respectively, to promote the orderly and rapid development of recombinant collagen.
Collagen can be used in medicine, medical beauty, cosmetics, food, light industry and other fields; Among them, the application in Yan value industry is based on:
1) Support: Type I collagen forms a fibrous elastic net in the skin to support the skin;
2) repair: promoting the growth of fibroblasts;
3) Moisturizing: Collagen has a large number of hydrophilic groups, and hydrolyzed glycine, alanine, aspartic acid and serine are all natural moisturizing factors;
4) Whitening: Collagen is rich in tyrosine residues, which can compete with tyrosine in skin and combine with the active center of tyrosinase, thus inhibiting the production of melanin.
Application of collagen in medical beauty: filling, facial rejuvenation and dressing.
1) filling: the parts suitable for collagen filling are eyes (crow's feet, lacrimal groove, etc. ), forehead, etc. At present, six products of four companies have been approved; Among them, Jinbo Bio "Weimeimei" is the first recombinant collagen filler (recombinant III humanized collagen freeze-dried fiber). Under the two paths of extraction and gene recombination, many enterprises are developing and auditing collagen fillers.
2) Facial rejuvenation: The four functions of collagen are suitable for facial rejuvenation and have broad prospects in mesoderm therapy.
3) Dressing: used for sedation, anti-inflammation, wound repair, acne repair, desensitization and redness removal after medical beauty projects.
Collagen is used in skin care products: anti-aging, whitening and moisturizing.
Principle of action: The oligopeptide hydrolyzed by collagen upregulates the expression level of TGF-βRII by activating Smad signaling pathway, thus increasing the expression of procollagen mRNA of type I and type III (COL 1A2 and COL3A1); Oligopeptide can inhibit the synthesis of MMP- 1 which destroys collagen, affect the expression of some genes in fibroblasts, and induce the production of collagen and hyaluronic acid. High-end brands such as Filojia and Estee Lauder all have collagen product lines, and skin care products such as Juzi Bio, Jinbo Bio and Meifa (Marubi Subsidiary) mainly use recombinant collagen.
Trend prospect: dressings and cosmetics provide profits and cash flow, research and development medical beauty and future medical product layout.
At present, the income and profits of head extraction and genetic engineering collagen enterprises generally come from dressings and cosmetics in the face value industry scene. Relying on R&D and financial strength, various head collagen enterprises are making great efforts to develop medical products and three types of medical devices for medical beauty, and such products will be listed in large quantities in the next 3-5 years; Head enterprises will form a multi-scene and multi-functional product matrix of medical care, medical beauty, cosmetics, food and beverage.
Risk warning:
Tighter supervision slows down the incubation of new brands, but it is beneficial to the healthy development of the industry in the long run; Powerful dressings and skin care products impact the traditional cosmetics market.
This article comes from Caijing.com.