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Second, cerebrospinal fluid examination: the customary view is mostly normal, some may have a mild increase in protein. Enzyme-linked immunosorbent assay (ELISA) is used to detect the increase of tau protein and decrease of Aβ in cerebrospinal fluid, which has high sensitivity and specificity for the diagnosis of senile dementia.
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Three, neuroimaging: In patients with suspected senile dementia, the tectonic impression of CT and MRI showed mild to severe cortical atrophy and enlarged ventricles, and the coronal position of MRI showed a decrease in the medial temporal lobe volume. In addition, the tectonic impression can also show other abnormalities, such as cerebrovascular disease, hydrocephalus and other factors causing dementia. PET (positron emission tomography), SP (single photon emission tomography), FDG-PET neurological impression often shows hypoperfusion and low metabolic rate of the whole brain, and bilateral frontoparietal lobes are more useful. Frontal lobe activity was significantly decreased in patients with a range of action changes compared with patients without neuropsychiatric symptoms.