"Twelfth Five-Year Plan" Biotechnology Development Plan

Ministry of Science and Technology

II 〇November 11

Contents

1. Situation and Demand 5

(1) Biotechnology is the commanding heights of scientific and technological development in the 21st century 5

(2) Biotechnology has become the strategic focus of competition among countries around the world 6

(3) The biological industry led by biotechnology will become a new growth point for economic development in the 21st century 7

(4) Biotechnology will become a breakthrough point in solving major human problems 7

(5) Biotechnology will become a support point for biosecurity 8

2. Overall ideas and guidance Principle 9

(1) Overall approach 9

(2) Guiding principles 9

3. Development goals 10

4. Key points Task 11

(1) Strengthen forward-looking basic research 11

(2) Break through a number of core key technologies 13

(3) Research and develop a number of major Products and technology systems 16

(4) Strengthen the construction of biotechnology innovation capabilities 20

5. Safeguard measures 22

(1) Deepen institutional reform and innovation, improve National coordination mechanism for biotechnology and industrial development 22

(2) Establish a multi-channel investment mechanism and increase fiscal, taxation and financial and other policy support 22

(3) Encourage the integration of industry, academia and research, and promote Building innovation capabilities of biotechnology enterprises 22

(4) Improving the intellectual property system and establishing a good incentive system 23

(5) Introducing and cultivating innovative talents and strengthening high-quality biological Construction of technical talent team 23

(6) Expand international and regional cooperation and make full use of foreign superior technical talent resources 24

Explanation of terms: 25

Biotechnology is As the main driving force for the development of international science and technology today, the bioindustry has become the focus of international competition and is of great strategic significance in solving the major problems facing mankind such as population, health, food, energy, and environment. The "National Medium and Long-term Science and Technology Development Plan (2006-2020)" (hereinafter referred to as the "Outline") has listed biotechnology as one of the five strategic priorities for scientific and technological development. The "State Council's Decision on Accelerating the Cultivation and Development of Strategic Emerging Industries" (hereinafter referred to as the "Decision") passed in September 2010 also included the bio-industry as a strategic emerging industry. In order to implement the arrangements of the "Decision" and "Outline", cooperate with the implementation of the "Twelfth Five-Year Plan for National Economic and Social Development (2011-2015)", and comprehensively promote the rapid development of my country's biotechnology and industry, the " "Twelfth Five-Year Plan for Biotechnology Development".

1. Situation and Demand

(1) Biotechnology is the commanding heights of scientific and technological development in the 21st century

Biotechnology is the fastest growing field of high technology in the world today one. In the past 10 years, the total number of papers in life sciences, biotechnology and related fields has accounted for more than 50% of the global natural science papers; in the past 10 years, among the 10 annual scientific and technological advances selected by Science, the fields of life sciences and biotechnology accounted for more than 50%. ; In 2008, 16 of the top 20 journals with SCI impact factors were in the life science category. The development of cutting-edge biotechnologies such as genomics, proteomics and stem cells has enabled a qualitative leap in human understanding of the living world; medical biotechnology will significantly improve human health and the quality of life; agricultural biotechnology will significantly improve agricultural products. yield and quality, reducing agricultural production costs; industrial biotechnology will accelerate the development of "green manufacturing", significantly reduce pollutant emissions, and lower production costs; the development of biomass energy will effectively alleviate the pressure of energy shortages; environmental biotechnology will play an important role in environmental governance It plays a huge role in pollution and improving the ecological environment; biotechnology will also play an irreplaceable role in ensuring national security and defending against bioterrorism threats.

Research related to life sciences and biotechnology has occupied a dominant position in scientific research.

(2) Biotechnology has become the strategic focus of competition among countries around the world

In order to seize the commanding heights of biotechnology, countries around the world have formulated national strategic plans, issued special policies, and significantly increased financial investment. . In 2009, the U.S. National Research Council released the report "New Biology in the 21st Century: How to Ensure the United States Leads the Coming Biological Revolution," recommending that national actions be taken to accelerate the development of "new biology," with a focus on strengthening life sciences. and the application of biotechnology in the four fields of food, energy, environment and health. In 2010, the British Biotechnology and Biological Sciences Research Council (BBSRC) released a five-year plan for the development of biotechnology, the "Bioscience Era: 2010-2015 Strategic Plan", which prioritized cutting-edge bioscience and technology as the first priority area of ??support. Japan has raised the biotechnology industry to a national strategic level, and has adopted the strategy of "building a country in the biotechnology industry" as Japan's new national goal, and developed the biotechnology industry through strong financial support. After the South Korean Ministry of Science and Technology announced the long-term science and technology development plan "2025 Vision", it also formulated the national plan "Bio-Vision 2016 (2006-2016)" to guide and promote the development of South Korea's biotechnology. In 2007, India released a biotechnology development strategy to quadruple biotechnology investment within five years. my country's "Outline" lists biotechnology as one of the five strategic priorities for scientific and technological development. The "Twelfth Five-Year Plan for National Economic and Social Development" proposes to cultivate and develop strategic emerging industries such as biology into my country's leading and pillar industries.

(3) The biological industry led by biotechnology will become a new growth point for economic development in the 21st century

Currently, biotechnology is entering the stage of large-scale industrialization, with biomedicine and bioagriculture As it matures, biomanufacturing, bioenergy, and bioenvironmental protection are rapidly emerging. Sales of the global bio-industry double every five years, with an annual growth rate as high as 30, which is 10 times the world economic growth rate. The bio-industry has become the fastest-growing economic field. According to a 2009 US research report, the revenue of the global pharmaceutical, biotechnology and life sciences industries reached US$917 billion in 2008, of which pharmaceuticals accounted for 7.461, reaching US$684.2 billion, and the biotechnology industry accounted for 2.127, reaching US$195.1 billion. According to the annual report of the biotechnology industry released by Ernst & Young on June 14, 2011, the output value of the biotechnology industry increased steadily in 2010, which was the third time that the global biotechnology industry achieved industry-wide profitability for the first time in 2009. Two profitable years. As of the end of 2010, there were more than 4,700 biotechnology companies in the world (mainly in the United States, Canada, Europe and Australia), including 622 listed biotechnology companies. The total revenue of listed biotechnology companies was US$84.6 billion, R&D investment was US$22.8 billion, and net profit was US$4.7 billion, an increase of 30% over 2009. In 2009, the output value of my country's biological industry reached about 1.4 trillion yuan, of which the output value of the pharmaceutical industry was 1.0381 billion yuan, biological agriculture was about 120 billion yuan, biomanufacturing was about 180 billion yuan, and bioenergy was about 28 billion yuan. In 2010, the output value of my country's biological industry exceeded 1.5 trillion yuan.

(4) Biotechnology will become a breakthrough point in solving major human problems

In the 21st century, the development of human society is facing increasingly serious problems such as health, food, energy, and environment. Modern life science and biotechnology research provides scientific and feasible solutions to these major challenges. In terms of agriculture, biotechnology is an important way to improve the level of agricultural science and technology in our country, promote the upgrading of the agricultural industry structure, and ensure national food security. Biological breeding technology will greatly increase the output of agricultural products and enrich the types of agricultural products.

In terms of medical care, with economic development and social progress, the "4P" medicine of "Preventive, Predictive, Personalized, Participatory" (Preventive, Predictive, Personalized, Participatory) will replace the traditional treatment-oriented medicine. The development of diagnosis and treatment methods, high-throughput screening, omics technology, bioinformatics and other technologies provides the possibility for preventive medicine and personalized treatment. Somatic cell reprogramming technology solves the problems faced by bioethics. Regenerative medicine with stem cells and tissue engineering technology as its core shows great application prospects and is expected to become a new treatment model after drugs and surgery. Bio-based materials have brought major changes to the field of materials. Bio-manufacturing technology with synthetic cells and biocatalysts as the core and bio-fuel technology with biomass as raw materials will gradually reduce the economy's dependence on oil and greatly reduce carbon dioxide (CO2). emissions, improve environmental quality, achieve sustainable economic development, and lead mankind into a low-carbon life. The advancement of biotechnology and industrial development will bring about huge changes in our lives and the way we develop our society and economy.

(5) Biotechnology will become the support point of biosecurity

With the acceleration of globalization and the rapid development of biotechnology, the biosecurity situation is becoming increasingly severe and has gradually become a concern. Basic issues of global security and development in many fields such as politics, military, economy, science and technology, culture and society. Developed countries, represented by the United States, have invested heavily in the field of biosecurity to consolidate and expand their dominant position, and their comprehensive biosecurity strength has developed rapidly. According to expert estimates, the annual economic losses caused by just 11 highly harmful agricultural invasive organisms in my country exceed 57.4 billion yuan. Since 2003, the raging epidemics of severe acute respiratory syndrome (SARS), highly pathogenic avian influenza, and influenza A (H1N1) have alerted us to pay more attention to the safety issues caused by emerging infectious diseases. Our country is one of the countries with the richest biological resources in the world, and it is also an important target area for developed countries to plunder biological resources. It is estimated that the ratio of introduction and export of biological genetic resources in my country is about 1:10, and the loss situation is quite serious. Our country’s ability to defend against bioterrorism urgently needs to be strengthened. Due to the destruction of natural forests, the habitats and distribution areas of wild animals are shrinking, coupled with man-made deforestation and indiscriminate hunting, leading to a sharp decline in biodiversity. Among my country's animal and plant species, 15-20 species are threatened. It is urgent to protect my country's biodiversity and ecosystem security. The key to solving biosafety issues lies in accelerating the research and development of biotechnology in medicine, agriculture, environment, etc. to ensure national interests and biosecurity.

II. Overall approach and guiding principles

(1) Overall approach

During the "Twelfth Five-Year Plan" period, my country's biotechnology development must uphold socialism with Chinese characteristics The great banner, guided by Deng Xiaoping Theory and the important thought of "Three Represents", thoroughly implement the Scientific Outlook on Development, fully implement the "Outline", adhere to the guiding principles of independent innovation, key leaps, support development, and lead the future, and closely focus on The major strategic needs of my country's economic and social development are to seize the commanding heights of cutting-edge technology, cultivate the growth points of strategic emerging industries, select breakthrough points for independent innovation, and consolidate the support points for scientific development.

(2) Guiding principles

1. Overall deployment and step-by-step implementation. Keep up with the forefront of international biotechnology development, aim at the country's major strategic needs, take into account reality and medium- and long-term development according to the focus of major national science and technology plans, integrate resources covering various fields such as medicine, agriculture, manufacturing, energy, and environmental protection, and integrate various fields. Departmental and local efforts, overall planning, and step-by-step implementation. Reflect the connection between basic research, applied research and industrialization.

2. Highlight innovation and support industries. Fully absorb the latest achievements of cutting-edge biotechnology, combine original innovation with integrated innovation, introduction, absorption, digestion and re-innovation, strengthen collaborative innovation, form independent core technologies, cultivate original innovation results, and form sustainable development capabilities. Conduct multi-disciplinary and multi-unit joint research on key key technologies and products covering upstream, mid-stream and downstream sectors, transform and upgrade the existing industrial structure, and support the development of strategic emerging industries.

3. Combining points and aspects and developing by leaps and bounds.

Focus on the research and development of cutting-edge core key technology points, major technology systems and major products represented by next-generation sequencing technology, build major industry-leading technology systems, establish national-level biotechnology incubators and integrated demonstration bases, and integrate government and industry All parties, including academic research funds and other forces, will promote the leapfrog development of the biotechnology industry.

3. Development Goals

During the "Twelfth Five-Year Plan" period, my country's biotechnology development goals are: to significantly improve the independent innovation capabilities of biotechnology, and to enter the world's advanced level of overall biotechnology. Some areas have reached world-leading levels. Biomedicine, bioagriculture, biomanufacturing, bioenergy, bioenvironmental protection and other industries are rising rapidly, and the overall layout of the bioindustry has been basically formed, promoting the bioindustry to become one of the pillar industries of the national economy, making my country a biotechnology power and a bioindustry power. Among them, the total number of SCI papers published ranks among the top 3 in the world; the total number of applications and authorized invention patents ranks among the top 3 in the world; the number of biotechnology R&D personnel has reached more than 300,000, and the total number of biotechnology human resources ranks first in the world; the biotechnology industry has The average growth rate remains above 15.

IV. Key tasks

Key tasks cover basic research, applied research and industrialization levels and links. It is implemented through major national science and technology projects, national key basic research and development plans (973 plans), national high-tech research and development plans (863 plans), and national science and technology support plans. Among them, basic research on major scientific issues in the development of life sciences and biotechnology is mainly implemented by the 973 program; core cutting-edge technologies and revolutionary key technologies in the development of biotechnology and industry are mainly supported by the 863 program; biotechnology achievements Transformation applications and industrial development demonstrations are mainly supported by the national science and technology support plan; major technical issues and integrated technology demonstrations involving overall, cross-industry and cross-region aspects in the development of biotechnology are mainly supported by major national science and technology projects, and through market mechanisms, Mobilize all aspects of society and promote it jointly; relevant innovation capacity building is jointly supported by corresponding plans of the Ministry of Science and Technology and the National Development and Reform Commission.

The implementation of the key tasks of this plan will be organized and implemented in the corresponding national science and technology plans on an annual, step-by-step and planned basis, and will be implemented in accordance with the organization and implementation management model of each plan to do a good job in each science and technology plan connection and cooperation. Establish and improve inter-ministerial coordination mechanisms involving departments related to biotechnology and bio-industry development, hold regular department coordination meetings, coordinate and coordinate national science and technology, economic and social development plans, integrate funds and strength of various national science and technology plans, and strengthen connection and Cooperate, allocate resources scientifically, rationally and effectively, and fully promote biotechnology research and development, industrialization, enterprise innovation capacity building and other work, forming a strong synergy to promote the rapid development of my country's biotechnology and industry.

(1) Strengthen forward-looking basic research

Faced with the changes in my country’s economic and social development model and the challenges brought by the new round of scientific and technological revolution, select key bottleneck issues and strengthen forward-looking Basic research, continuously improve the level of basic research in my country's biotechnology field and the ability to solve major scientific problems, drive the combination of basic research and technical science, and lead the development of high-tech in the future.

Development focus:

1. Agricultural science

Focusing on agricultural animal and plant breeding, scientific breeding and cultivation, efficient use of resources, effective prevention and control of pests and diseases, and improvement of the ecological environment We will carry out research on high-yield, high-quality, disease-resistant, and efficient agriculture such as efficient utilization of farmland resources, pest control, biosecurity, and safety of agricultural products, and build a sustainable agricultural, forestry, and grassland ecology and comprehensive agricultural system.

2. Population and Health Sciences

Integrating the development frontiers of life sciences and focusing on major scientific issues in disease pathogenesis and prevention and treatment, we will carry out research on non-communicable diseases, chronic complex diseases, aging and Basic research on aging-related diseases, family planning and reproductive health, disaster medicine, infection and immunity and other disease mechanisms and their prevention and treatment; in response to the major needs of infectious diseases, research on the pathogenesis of major pathogens and important infectious diseases, and the creation of important vaccines Scientific issues in China, new technologies for diagnosis, treatment and early warning of important infectious diseases; focusing on the science of traditional Chinese medicine with Chinese characteristics, carry out scientific connotation interpretation of basic theories of traditional Chinese medicine, innovative development of basic theories of traditional Chinese medicine, application of traditional Chinese medicines and prescriptions, and basic research related to dialectical argumentation of acupuncture.

3. Industrial Bioscience

Research on new functional artificial life devices and their integration, genomic network analysis, precise genome synthesis principles and technologies, and new theories on the synthesis of major bio-based products , new ways, new methods, etc.

(2) Break through a batch of core key technologies

Select core key technologies with Chinese characteristics and advantages, concentrate superior resources, achieve key breakthroughs, and strive to occupy a place in the international biological frontier science field , seizing a number of commanding heights in international biotechnology research and development.

Development focus:

1. "Omics" technology

The development of next-generation sequencing technology will be a breakthrough for my country's biotechnology to achieve leapfrog development and drive genomic technology , the rapid development of various omics research technologies such as transcriptomic technology, proteomic technology, metabolomic technology, epigenome technology, and structural genome technology, the development of high-throughput biomedical data analysis and text mining technology, and high-throughput samples Analytical technology, micro-sample extraction and amplification technology, massive data analysis technology, etc., to accelerate the application of omics technology and bioinformatics technology in the fields of disease prevention and control, clinical diagnosis and treatment, biomanufacturing, variety creation, and new drug development.

2. Synthetic biology technology

Develop high-throughput, low-cost DNA synthesis technology and efficient assembly of gene fragments, analysis of protein structure and function, directional design and synthesis technology, and standardization Construction technology of biological components and functional modules, establishing application technology of synthetic biology in drug precursors and intermediates, bioenergy, bio-based chemicals, etc., and gradually exploring the application of synthetic biology in the fields of medicine and energy.

3. Bioinformatics technology

Make breakthroughs in key technologies such as calculation, design, assembly and application of biological regulatory elements, and research and develop individual genomes, population genomes, personalized information search engines and various New biological data analysis technology, research on disease risk analysis, disease diagnosis and treatment models and system research based on individual omics data; research on data mining and analysis technology related to agricultural biological adversity stress; establish national data convergence in the fields of life sciences and medical technology , management and *sharing technology platform.

4. Stem cells and regenerative medicine technology

Study the mechanisms of differentiation, development, and interaction between embryonic stem cells, adult stem cells, induced pluripotent stem cells (iPS cells), and the microenvironment in the body. Cell reprogramming, genetic differentiation and stem cell induced differentiation technology, stem cell isolation, identification, amplification and identification technology, key technologies such as immune rejection, safe implantation of stem cells and accurate observation and tracing in vivo, three-dimensional construction of complex organs, and preservation of tissue engineering medical products technology and other core key technologies.

5. Gene therapy and cell therapy technology

For major diseases that seriously threaten human health, such as malignant tumors, cardiovascular and cerebrovascular diseases, genetic diseases, and autoimmune diseases, a series of A batch of forward-looking key biotherapy technology research, such as targeted gene therapy, cell therapy, and immunotherapy, will be used to drive the research and development of key products with breakthroughs in key technologies, and accelerate the application of biotherapy technology in clinical treatment.

6. Molecular typing and personalized diagnosis and treatment technology

Carry out research on key technologies for molecular typing, staging and early diagnosis of major diseases and common diseases; establish standardized, normalized and digital * Sharable clinical data, specimen databases and information systems; genome-wide association analysis technology for studying major diseases, discovery, confirmation and clinical evaluation of biomarkers for molecular typing of major diseases, and individualized clinical diagnosis and treatment plans for major diseases .

7. Biochip and bioimaging technology

Develop gene chips, protein chips and chip laboratory products with independent intellectual property rights and market prospects for clinical testing and health and epidemic prevention. Super-resolution imaging to study biomolecular structure, three-dimensional morphology and rapid changes, large-scale, cross-level high-resolution biological imaging; fast, non-destructive, parallel high-throughput imaging monitoring to study single-molecule resolution/multi-molecule network regulation, cells, patterns In vivo three-dimensional non-destructive structural imaging monitoring of small animals and the human body as a whole, high-resolution structural and functional three-dimensional non-destructive imaging monitoring of the nervous system; research on integrated modeling methods based on multi-level and multi-parameter imaging information, combined with imaging information monitoring and diagnosis and treatment of major clinical diseases representation.

8. Bioprocess engineering technology

Research and develop online detection technology of macro-metabolic information and cell growth environment information of biological processes, biological process optimization and control technology; biological macromolecules and biological Separation, extraction and purification technology of small molecules; fermentation process and separation coupling technology; design, amplification and manufacturing technology of new high-efficiency animal and plant cell bioreactors and photobioreactors.

9. Biocatalytic engineering technology

Carry out enzyme-directed transformation, efficient expression, immobilization, coenzyme regeneration, multi-enzyme coupling, enzyme-chemical coupling, enzyme-fermentation coupling, and various Research on key technologies such as symmetric and enantioselective bioconversion technology, non-aqueous biocatalytic reaction process optimization and amplification technology, establish biocatalytic engineering technology with independent intellectual property rights, low cost, and can be industrially produced, and improve my country's industrial enzyme development and application level.

10. Drug target discovery and drug molecule design technology

Research drug target network analysis technology based on systems biology, target protein function and bioactive conformation simulation technology, based on new functional genes High-throughput screening models of their signaling pathways, structure-based drug design technology for multiple targets, key technologies such as computer-assisted combinatorial compound library design, synthesis and screening, design methods of drug lead compounds, drug virtualization for druggability evaluation of compounds Design technology, network pharmacology design technology, drug metabolism engineering simulation and other technologies.

11. Animal and plant variety design technology

Based on the main plants (rice, wheat, corn, soybeans, cotton, rape, vegetables, forest grass, etc.), animals (pig, cattle, Sheep, chickens, etc.) are the research objects, focusing on the molecular composition analysis of important animal and plant variety traits, multi-gene aggregation of excellent traits; information systems for animal and plant variety molecular design, variety molecular design engineering, and technical systems and verification of variety molecular design.

12. Key biosafety technologies

Carry out research on key biosafety monitoring and early warning technologies and the development of public health emergency drugs and equipment; study the cross-species transmission mechanism of pathogens and establish biological Traceability technology for threat-related pathogens; carry out research on key technologies for biological invasion prevention.

(3) Research and develop a number of major products and technology systems

Focusing on my country’s current urgent need to transform the economic development model and develop strategic emerging industries, strengthen integrated innovation of biotechnology, focusing on Break through a number of revolutionary key technologies, develop major products with independent intellectual property rights and market competitiveness, focus on promoting the development of biomedicine, bioagriculture, biomanufacturing, bioenergy and bioenvironmental protection industries, and realize my country's biotechnology research and development Strategic transformation from technology accumulation to industrial development.

Development focus:

1. Biomedical technology and products

In order to meet the basic drug needs of the people and cultivate and develop the pharmaceutical industry, break through a number of drugs Create key technologies and production processes, develop innovative drugs, transform major drug varieties, improve technology platforms for new drug creation and traditional Chinese medicine modernization, build a number of strategic alliances for technological innovation in the pharmaceutical industry, and basically form a national drug innovation system with Chinese characteristics.

Focusing on major infectious diseases such as AIDS, viral hepatitis, and tuberculosis, we will make breakthroughs in key technologies such as clinical diagnosis, prediction and early warning, vaccine research and development, and clinical treatment, and develop new diagnostic reagents and new vaccines to effectively reduce the risk of AIDS, viral hepatitis, and other major infectious diseases. New infection rates and case fatality rates for hepatitis and tuberculosis.

Establish new technologies for large-scale and rapid response production of vaccines and antibodies, a systematic technical system for vaccine effectiveness and quality evaluation, and humanized antibody construction and optimization technologies; transform traditional vaccines to increase efficiency and target new Develop new vaccines and antibody drugs for the emergence and recurrence of major infectious diseases and multiple infectious diseases; develop therapeutic vaccines and antibody drugs for major non-infectious diseases such as malignant tumors, cardiovascular and cerebrovascular diseases, metabolic diseases, and autoimmune diseases. .

Make breakthroughs in major key technologies of a number of in vitro diagnostic instruments, equipment and reagents, develop a number of innovative products with independent intellectual property rights, achieve key breakthroughs in high-end products such as integrated chemiluminescent immunodiagnostic systems, and accelerate The structural adjustment, optimization and upgrading of the in vitro diagnostic industry have greatly enhanced the market competitiveness of my country's in vitro diagnostic industry.

Break through a batch of cutting-edge high-end biomedical materials products, carry out the research and development of a batch of high-value alternative products that mainly rely on imports, create a batch of large-scale and wide-ranging biomedical materials, and break through the individual design and development of biomedical material products. Surface modification of biomedical materials, biomechanics, durability and safety testing of biomaterial products and other key technologies.

2. Bio-agricultural technologies and products

Focusing on the production of major crops and livestock, make breakthroughs in key technologies such as gene cloning and functional verification, large-scale transgenics, and biosafety, and improve the cultivation and production of genetically modified organisms. Safety evaluation system, obtain a batch of functional genes with important application value and independent intellectual property rights, cultivate a batch of major new genetically modified varieties that are resistant to diseases and insect pests, resistant to stress, high quality, high yield, and efficient, and realize new genetically modified cotton, high-quality corn and other new varieties. The industrialization of varieties will improve the overall level of biological breeding in my country, enhance the ability of independent innovation in agricultural science and technology, and promote agricultural efficiency and increase farmers' income.

With the goal of achieving large-scale development, accelerate the research, development and industrialization of green agricultural biological products and forest dangerous pest control technologies; develop biopesticides, bioveterinary drugs, animal vaccines, biofertilizers, and green plants Demonstration pilots and popularization of the application of green agricultural products such as growth regulators, and promotion of the research, development and industrialization of fully degradable agricultural films; research and development of biopesticides, biofertilizers, new animal vaccines and diagnostic reagents, biotech drugs and veterinary drugs for animals, and biological Feed additives, etc.

For special biological resources, focus on research on resource utilization engineering technologies for important rare medicinal fungi such as Cordyceps sinensis and Ganoderma lucidum, and develop a series of high value-added products; discover and screen fungi that grow in special environments and have important application value. Biological resources, carry out research on artificial cultivation technology, establish a seedling breeding base, and develop a series of deeply processed products.

Research and develop key technologies for the selective breeding and breeding of new marine fishery species and standardized, large-scale, ecologically healthy breeding, develop monitoring, forecasting and immune prevention technologies for major aquaculture diseases, and establish aquatic product quality inspection systems.

3. Biomanufacturing technology and products

Focus on the construction and optimization of biosynthetic pathways for chemical products, comprehensive utilization of raw materials and biorefinery, industrial biocatalysis and transformation, and bio-chemical combinations Synthesis and other key technologies to break through the industrialization bottleneck of biomanufacturing of major chemical products such as bio-based platform compounds, chiral chemical intermediates, and bio-based materials. Form a platform technology system for the manufacturing of organic acids, chemical alcohols, bio-based materials and other products, and form an innovative bio-manufacturing route for the production of chiral alcohols, chiral acids, steroids and other high value-added chiral intermediates.

Research and carry out the application of biotechnology in textile, papermaking, leathermaking and other industries, develop new technologies and equipment such as biotextile, biodegumming, biotanning, and biopapermaking, and promote textile, papermaking, and leathermaking. Other companies apply biotechnology processes to promote cleaner production in the industry.

Choose traditional brewing products such as wine, soy sauce, and vinegar, apply modern biotechnology and engineering technology to improve bacterial strains, optimize and control the brewing process, improve product quality, reduce resource consumption, and reduce the environment pollution and improve the overall competitiveness of the industry.

4. Bioenergy technologies and products

Research and develop the ultimate key technologies in the manufacturing process of bioenergy products such as non-grain bioethanol, biodiesel, biogas, and biohydrogen production. and special equipment, using industrial and urban domestic waste as raw materials to establish a large-scale production technology demonstration of bioenergy products.

Research and develop the core key technologies of microalgae biological carbon sequestration, establish an industrial demonstration system with an annual total carbon dioxide fixation of more than 10,000 tons, take the lead in realizing the industrialization of microalgae carbon sequestration for the first time in the world, and develop high-added carbon dioxide at the same time. A series of microalgae products with high value provide technical, economic and environmental evaluation indicators for the development of large-scale carbon dioxide fixation by microalgae and microalgae energy, and provide a demonstration for the large-scale promotion and application of microalgae biological carbon fixation technology.

5. Biological environmental protection technologies and products

Vigorously develop new environmentally friendly biological technologies, new processes, and new equipment; focus on the development of high-performance water treatment flocculants, coagulants and other biotechnologies products, develop waste gas and wastewater biological purification technology, develop new aerobic, anaerobic and composite high-efficiency reactors, and new high-efficiency biological nitrogen and phosphorus removal processes; develop new species of pollutant-degrading organisms, and develop organic pollution in the petroleum refining and pharmaceutical chemical industries. Biodegradation technology promotes the biodegradation and remediation of pollutants such as petroleum, heavy metals, and pesticides.

Carry out research on microbial desulfurization technology for coal, industrial waste gas and flue gas, focusing on the research and development of high-efficiency functional bacteria selection technology, microbial control technology of sulfur metabolism pathways, and composite microbial desulfurization technology. Research on multi-bacteria, single/multi-phase reactors, and composite technologies of biochemical/physical and chemical methods promote the industrial application of microbial desulfurization technology.

(4) Strengthen the construction of biotechnology innovation capabilities

According to the needs of the development of biotechnology, systematically strengthen the construction of biotechnology innovation capabilities and optimize scientific and technological resources in the fields of life sciences and biotechnology research. Configuration, build a national key laboratory, a national engineering technology research center, a research and sharing platform and an industrialization demonstration base with reasonable layout, scientific efficiency and world-class level, and promote the integration and development sharing of biotechnology resources. Provide effective support for biotechnology research and industrialization of results.