First of all, it should be pointed out that hepatitis B big three-yang and hepatitis B small three-yang are just common names, not medical terms or disease names. It is defined according to the results of five items of hepatitis B (commonly known as two and a half). The detection index of hepatitis B "two and a half" is one of the most common and effective means to detect liver diseases at present, which can explain many clinical problems. Therefore, the "two-and-a-half" examination has been widely carried out in hospitals at all levels. It is customary for people to rank these five indicators in order, namely HBsAg (hepatitis B surface antigen), anti -HBs (hepatitis B surface antibody),-—HBeAg (hepatitis B E antigen), anti -HBe (hepatitis B E antibody) and anti-—HBc (hepatitis B core antibody), and then the first, third and fifth items (namely HBsAg and hepatitis B core antibody) will be positive.
The "three major positives" of hepatitis B means that three of the five indicators (two and a half) of hepatitis B are positive, namely surface antigen (HBsAg), E antigen (HBeAg) and core antibody (HBcAb).
Small three-positive hepatitis B means that three of the five (two and a half) indicators of hepatitis B are positive for surface antigen (HBsAg), e antibody (HBeAb) and core antibody (HBcAb).
"Hepatitis B big three yang" refers to the active virus replication, often accompanied by hepatitis B virus DNA (deoxyribonucleic acid) positive, highly contagious, and more likely to evolve into chronic hepatitis B. Hepatitis B small three yang indicates that the virus has basically stopped replicating, and the infectivity is smaller than that of "hepatitis B big three yang". If the DNA of hepatitis B virus is negative, it is basically no longer contagious or less contagious. In recent years, it has been found that some patients with small three-positive hepatitis B virus have positive serum HBV-DNA and are also contagious, which proves the existence of HBV variants.
Some people say that "hepatitis B is small and sanyang" is better than "hepatitis B is big and sanyang" and it is not contagious. This is a wrong idea. "Hepatitis B, Xiao Sanyang" is still contagious, but the virus content in blood circulation is relatively low, and Xiao Sanyang is more likely to turn into cirrhosis. Whether the situation of hepatitis B virus-infected people is good or not has nothing to do with whether it is "hepatitis B small three yang" or "hepatitis B big three yang", but whether the infected people have impaired liver function. Some people who "hepatitis B is a big three-yang disease" want to become "hepatitis B is a small three-yang disease" and even use some drugs, which is actually wrong. Because "hepatitis B big three yang" is not a sign of liver function damage, it just shows that the virus content in blood is higher than "hepatitis B small three yang", and virus replication is more active. Whether the liver function of hepatitis B virus-infected people is damaged is not directly related to the degree of virus replication. For this problem, we can understand it this way: hepatitis B virus is like a tenant who lives in a liver cell house without authorization, using things and food in the room to reproduce without destroying the house. So when the owner has no ability to drive him away (when the resistance is weak), it is generally a state of peaceful coexistence. If viruses are more diligent, they will breed more offspring. Sometimes they are lazy and copy less, just like people's activities and rest. When the body's immune system resists or kills hepatitis B virus, this balance is broken. Tenants and owners began to expel each other and fight in the house, which could easily lead to the destruction of the house (liver cells) and become hepatitis B.
Some "hepatitis B big three yang" will naturally become "hepatitis B small three yang" in a few years. If it is completed before the age of 25, it is the process of clearing the virus for the body, and the damage to the liver is also light, and a few can recover slowly; However, if hepatitis continues to be active, transaminase will rise repeatedly during the clearance reaction, and patients will have different degrees of liver fibrosis or cirrhosis around the age of 40, and even turn into hepatitis B and small three positive. Therefore, in the treatment of chronic hepatitis B "big three yang" or "small three yang", we should cooperate to reverse liver fibrosis and block liver cirrhosis. At present, this treatment can only be realized by Japanese neutrino technology or German O3 technology. Blocking the sustainable development of liver cirrhosis is particularly important for the late stage of hepatitis B big three yang and hepatitis B small three yang.
Second, why is liver disease difficult to treat?
Liver disease is caused by virus, but this kind of liver disease virus has a series of drug-resistant structures and characteristics, and drugs can do nothing at all.
1. Hepatitis B is caused by hepatitis B virus. This virus has two layers in total, and it is covered with a dense and hard protein shell, which is specially used to resist the effects of drugs on it. The drug is ineffective for him;
2. Viruses replicate in liver cells, and drug molecules are larger than liver cells, so they can't get into liver cells at all, so they can't have any effect on viruses;
3. The virus has a replication module, which exists in the nucleus, specifically inducing the virus to replicate and reproduce at high speed, so that drug molecules can't even enter the cell, let alone enter the nucleus;
4. Viruses will denature and mutate. As soon as the drug approaches it, it will quickly change its structure and characteristics, making it impossible for the drug to capture it and escape the effect of the drug on it;
In a long time, virus will be associated with human genes. At this time, no medicine can be removed, and other high-tech medical means must be used;
6. The life cycle of virus is 90 days. The attached drug molecules do not have the efficacy of swallowing and killing for such a long time, and are generally digested by the human body quickly, so it is impossible to kill the virus.
In the past, drugs such as interferon, lamivudine or adefovir dipivoxil were often used in medicine, but these drugs could only inhibit virus replication to a certain extent, and could not reduce and treat viruses at all. Moreover, these drugs have large molecular weight, which often cause more serious damage to the liver when treating the liver, leading to increased necrosis of liver tissue and accelerated fibrosis. In addition, these drugs have great side effects, such as high fever, hair loss, sleep disorders, etc., which are unbearable for ordinary patients. After stopping the drug, the virus rebounded even more.
In addition, these western medicines often lead to serious mutation of the virus, which makes it impossible to treat it with any drugs in the later stage.
Third, a new breakthrough in the treatment of liver disease.
With the development of medical science and technology, the treatment standards and principles of liver diseases have been revised many times. First of all, although there is a virus, if the liver function is normal, it will not be treated, and then it will be treated if it is abnormal; Subsequently, interferon came out, and hepatitis B treatment entered the treatment stage of inhibiting as long as there was virus. 20 10 with leading technologies such as Japanese neutrinos overcoming the key technology of virus replication, hepatitis B treatment entered the stage of virus elimination and began to change from clinical negative to hepatitis B treatment standard. But under its treatment, the recovery of liver function becomes extremely simple, and it can be recovered several times.
Fourth, the new technology of hepatitis B treatment
In 2009, breakthrough technologies for three major liver diseases were successfully developed. The first is neutrino dialysis technology in Japan; Then, Germany's O3 technology also oscillated. At the end of the same year, the therapeutic vaccine researched by Fudan University in China also announced the completion of phase III clinical trials and was officially listed. Based on different mechanisms, the three technologies creatively overcome the key technical problems of virus treatment from different angles. Among them, Japanese neutrino liver dialysis technology is widely used by most medical institutions in the world because of its convenient treatment, low cost and relatively fast recovery.
Japanese neutrino dialysis technology and German O3 technology, because they almost simultaneously overcome the key technical problem of liver disease turning negative, have been merged into two major technologies to conquer liver disease in the world. The core of this technology is neutrino collision and targeted decomposition system. According to the ability of neutrino beam to induce, automatically identify, dissociate, destroy and accurately react with zero mass in the process of protein synthesis, it can completely eradicate several deep liver diseases that drugs can't eradicate, at the same time, it can assist the liver to complete various functions and reverse fibrosis for moderate and severe patients such as liver injury.
Neutrinos belong to the category of high-end physics, and their principles are profound and complicated. Because of its specific ability to disintegrate and destroy virus structure and life activity, it plays an irreplaceable role in the treatment of hepatitis B, hepatitis B, hepatitis B and other viral diseases, which can be divided into three categories: U neutrinos, electronic neutrinos and T neutrinos. U neutrinos mainly have the ability of high-energy disintegration and destruction. According to the difference between pathogens and normal human tissues, they can instantly condense the drug-resistant shell of virus protein structure with super energy. T neutrinos are extremely tiny, which can break through the cell membrane melting, destroy the replication module of the virus, decompose the gene nucleus that induces virus mutation, and make its life activity unable to regenerate. T neutrinos can mainly connect with T cells, thus activating, strengthening and rebuilding human immune system, dissolving and repelling abnormal components, repairing damaged liver tissue, balancing the whole immune system and relieving symptoms quickly; Electronic neutrinos mainly kill viruses and other abnormal tissue components directly by remote sensing, instantly induce nitric oxide and nitric oxide synthase, and synchronously kill viruses by tracking. Because heat will be generated during the treatment reaction, patients will feel fever and pain at the focus. At the same time, electronic neutrinos themselves will generate heat in tissues, worsen the living environment of viruses and strengthen the killing effect on related viruses, because viruses are more likely to die prematurely at abnormal temperatures. In addition, electronic neutrinos can strongly improve the microcirculation of the liver, help complete the metabolic function of the liver, and eliminate the pathogenic factors accumulated in the liver (including toxins deposited after taking drugs, etc.). ), and prevent cirrhosis and ascites.
The synergistic effect and step-by-step effect of the three drugs make the drug "get twice the result with half the effort" and the overall treatment effect increases exponentially. At the same time, it can interfere, repel and shed the integrated link between virus and human gene chain, thus cutting off the stubborn root of hepatitis B.
The simultaneous action of neutrinos and three kinds of particle rays, combined with various mechanisms, can completely eliminate every dominant and invisible cause of hepatitis B, and completely cure it without leaving the root of the disease. Ordinary patients can take effect on the spot, and can realize several basic rehabilitation soon.
Five, the Nobel Prize in Medicine nomination technology and was named the world's top ten news events.
Because of its outstanding achievements in medicine, Japanese neutrino technology attracted the attention of the Swedish Nobel Prize jury and was nominated for the medical prize. At the same time, among the top ten news events in the world published by Fortune magazine and Forbes, Japanese neutrino technology is regarded as one of the top ten news events in the world because it has overcome the key technology of world medical problems such as liver disease.