Yan Xijun, Han nationality, Chinese *** party member, chief pharmacist, doctoral degree, the State Council special subsidy experts, is now Tianjin 14th People's Congress, Tianjin Federation of Industry and Commerce, vice chairman of the Chinese Pharmaceutical Association of Pharmaceutical Affairs Management Committee, vice chairman of the Bohai Rim Enterprises Cooperation and Promotion Association, president of Tiansili Group Co. A chance opportunity, so that Yan Xijun began to embark on a new entrepreneurial road.
In 1989, Yan Xijun was transferred to the People's Liberation Army Hospital No. 254 as the director of the Pharmaceuticals and Equipment Department, responsible for the hospital's medical equipment, drug purchases, as well as the supply and management of drugs. At that time, the hospital funds are more difficult, the drug and equipment section of the funding is even less, the hospital to develop, to the drug and equipment section of the pressure naturally fell mainly on the shoulders of Yan Xijun, relying only on the limited allocation of the higher-ups is obviously not possible and unrealistic. To find the hospital leadership, the leadership said, you want money, no; to policy, can give, you can engage in "independent development, inward and outward". This sentence, in Yan Xijun heart lit a lamp.
In order to find a source of income, Yan Xijun engaged in a variety of business, but are no return, the money did not earn, but earned a lesson. Finally, he decided to return to his old profession --- pharmaceutical up, this time he set his sights on a deep historical and cultural deposits of Chinese medicine, dedicated to the development of modern Chinese medicine --- compound danshen drip pill.
Compound Danshen Drop Pills.
This is a road full of hardships and challenges. The dosage form of Chinese medicine for thousands of years has been "pills, dispersions, creams, dans and soups", and he preferred to condense the efficacy of the medicine in a few drops of rice, how easy it is to talk about! However, Yan Xijun will never give up on the things that he has recognized.
No funds, the start of the difficulties can be imagined. The company's main goal is to provide the best possible service to its customers, and the company's goal is to provide the best possible service to its customers, and to provide the best possible service to its customers. Lack of technical information, they *** with drilling; no technical standards, they personally tested over and over again: humidity, temperature, viscosity, content, stability, effectiveness, safety ...... like the Tang Monk to fetch the scripture to go through nine hundred and ninety-one difficulties, after countless sleepless nights, experienced countless failures of the tragic ...... Kung Fu is not a success, when they personally designed the drip pill machine spit out a small black pearl-like particles, the couple moved to raise their hands to celebrate, "Success! We did it!" At the time when the development of Compound Danshen Drop Pills was beginning to bear fruit, Yan Xijun's mind came up with another idea, he wanted to transform this achievement into a product and bring this product to the market. Compound Salvia divinorum pills of the new drug certificate is still in the process of declaring, he would like to "no fetus, the first seek maternity ward", planning the construction of a 5000 square meters, the main building on the cost of more than 800 million yuan of modern pharmaceutical buildings.
The news spread, a stone stirred up a thousand waves! Many people say that Yan Xijun is "crazy". At that time, 254 hospitals and the higher authorities in accordance with the provisions of the establishment of military hospitals, can only invest 1.4 million yuan to the preparation room, but the rest of the 7 million yuan, plus investment in equipment, the funding gap of nearly 10 million yuan, Yan Xijun self-financing. The huge funding gap is not only a problem, more difficult is due to the lack of funds, the preparation of the preparation building of the planning can not be a project, can not be launched.
Yan Xijun instinctively felt that this was another major challenge in his life. He firmly believed that compound danshen drip pills have great prospects for development. Because he knew that there are about 400 million people in the world suffering from coronary heart disease, and the number of people who die every year because of this is more than 12 million! Coronary heart disease has become the "first killer" of mankind, the ancient Chinese medicine will certainly make a big difference; the state began to brew the start of the modernization of traditional Chinese medicine project, will certainly accelerate the progress of the ancient Chinese medicine will have a bright future. If this time and then do not seize the opportunity to do fast, is to miss the opportunity, is not responsible for the cause of ah!
Wu Feng, his lover, has always stood by him at critical moments. In order to find funds, the couple traveled every day between the major pharmaceutical companies in Beijing and Tianjin, inviting them to participate in the shares. Their sincerity paid off, and they eventually found an investment partner, Tianjin Central Pharmaceutical Factory, which solved part of their valuable capital.
His persistence was also supported by the Director of the Beijing Military Region Logistics Department, Dong Mingxiang (now the Minister of the Beijing Military Region Joint Logistics Department), who put forward the "overall design, step by step" program, which reasonably solved the problem of insufficient funds. "Plus Yan Xijun's active struggle, the preparation building was finally approved to establish the project.
The preparation of the building, so that the military Yan Xijun show another aspect of the talent. As long as he does not travel, he is almost every day "long" on the site, from design to construction, from procurement to feed, check each item. Even if it's a piece of rebar, a bag of cement, he has to be carefully calculated. His comrades laughed and said him, "Your old Yan on his own son has not been so careful!" Looking at the beautiful modern pharmaceutical building in front of him day by day grow tall, Yan Xijun feel immensely exhilarated.
By the end of 1993, the building was built, after several trial production, reporting, verification and clinical, compound danshen drip pill also successfully obtained the national new drug certificate and production number, at the same time, the technical performance, advanced process of the drop pill preparation production line was also built. The predecessor of TIANSHILI GROUP---Angel Force United Pharmaceutical Company was born in May, 1994.
New drugs on the market, this is only the first step in the long march, to make it into a commodity, this intermediate still have to "climb the snowy mountains", "cross the grasslands", "snatch crossing the Dadu River "...... but" bitter "and" difficult "to Yan Xijun are nothing, many years of military career has long created his hard-working, dare to fight the battle of Character. In order to run the market, he rubbed his lips and feet, leading his comrades to fight a "war of attrition", a city, a city, a hospital, a hospital to do publicity, tasted the "hardship", experienced a "A thousand difficulties and dangers", traveled all over the country --- provinces, cities, counties. After more than half a year of hard work, the market finally Yan Xijun smile, hospitals, pharmacies began to eight boxes, ten boxes, three boxes, five boxes of their medicine. The production and sales of compound salvia pills have entered a stage of rapid development.
Next, good news and honors came one after another, in 1995, the sales income of 16 million yuan, in 1996 reached 27 million yuan, in 1997, sales income exceeded 80 million yuan. The "Compound Danshen Drip Pill and its series of research" has won the second prize of the army scientific and technological progress, the third prize of the national scientific and technological progress, was included in the national "Ninth Five-Year Plan" major scientific and technological achievements promotion project, the national 973 basic science research projects.
In 1998, Yan Xijun experienced an unforgettable period! At the beginning of the year, the Beijing military region to tianshili as the core enterprise, the establishment of the Beijing military region pharmaceutical group (division-level establishment), Yan Xijun served as general manager of the group. Just as Yan Xijun complacent, ready to do a great job in the army pharmaceutical industry, the military region conveyed the decision of the Party Central Committee and the Military Commission, requiring the troops to stop all production and business activities, enterprises and troops decoupled! It is the duty of soldiers to follow orders! "Where to go from here? Is to take off the uniform, to go on a difficult road of business, or continue to stay in the army, with their own painstakingly operated 'TIANSHILI GROUP' goodbye?"
The troops and Tianshili are Yan Xijun's "life", Yan Xijun encountered the first dilemma of his life!
The leadership of the military region said to him: "The force reduction, but not the reduction of talent, you are the force's excellent talent, it is possible to stay, go and stay in the problem of your own decision. The words are full of retention.
The comrades advised him: "You so long military age, both honorary second-class merit, and won the army and the country's science and technology awards, both the senior position, but also won the State Council's special allowances for special experts to stay in the army steadily for a lifetime of how good." He knew that his comrades were doing him a favor.
That night, he tossed and turned, sleepless all night, the scene of his military career replayed in his mind ......
The next morning, he made a bold decision: do not want to be with the troops to the official position, do not talk to the troops on condition, out of uniform, the courage to go to the sea of business!
The leaders of the army said with concern: "Old Yan, you are not cutting off your own way? Even if you do not want the local arrangements for work, at least do a retirement, the more than 100,000 yuan of the settlement in hand ah!"
Yan Xijun said fondly: "I am an orphan, 16 years old came to the army, is the army training me to grow up, gave me now everything. My roots have been rooted in the barracks, my soul will always belong to the barracks. However, the present TIANSHI is still just a seedling, and we people have the responsibility to nurture it to grow up. Let's call it the unfinished task that the army has given to me, a veteran!"
Driven by him, 47 cadres and volunteers who started TIANSILI with him did not make any request to the organization, and collectively took off their uniforms and went to sea. Lead thousands of employees, the future road how to go? How to develop the enterprise? All of this is to "break" and "create" in the search for answers.
The original military-run enterprises, although there is no tax and other aspects of enjoying what preferential policies, but cadres, volunteers, wages from the army to ensure that the success or failure of business operations, wages can be guaranteed. The company's business is self-managed, self-financed, and self-supporting. Yan Xijun is well aware of the huge risks faced by the market, are still young Tiansili alone to bear; only to change everyone's thinking from the traditional concept of "drought and flood", the interests of each person and the fate of the enterprise firmly tied together to maximize the mobilization of everyone's ingenuity and enthusiasm to make "Tiansili" a success. TIANSHILI" ship in the market economy of the sea to break the waves. For this reason, he proposed to carry out shareholding system transformation of the enterprise in accordance with the requirements of the modern enterprise system.
The proposal was met with strong opposition. Some people questioned: "You let us invest in shares, if the enterprise is lost, we will not lose all our money?" Restructuring of the General Assembly, Yan Xijun generous speech: "business is not restructuring, there is no future; we are not tied to a warship, it is difficult to develop a good business. If the enterprise loses money, I'll lose my family's money as well as everyone else's! Before the war is not fighting to lose, the enterprise is not organized to lose, this is not the style of our soldiers! What is the style of a soldier? Military style is to dare to win, perseverance, hard-working, courageous, only with this style, our business can survive, can develop and grow!" He also solemnly asked everyone: "The equity restructuring of the enterprise is an opportunity and a challenge for everyone. We must strictly abide by the state's policies and regulations, neither can we borrow money from our business, nor can we borrow money from the institutions, we just have to actually take on this debt ourselves, self-pressurized, weighted forward."
Tianshili's shareholding transformation has received strong support from the Tianjin municipal party committee and municipal government, which agreed to a complete restructuring of Tianshili in accordance with the modern enterprise system. Yan Xijun and his wife Wu Feng took the lead and took all their family savings to buy shares in the enterprise, and his comrades and most of his backbone also bought shares. It is relying on the Tianjin municipal party committee and municipal government's support, Yan Xijun's active drive, as well as the spirit of this group of entrepreneurs dare to take risks, driving Tianshili into the fast lane of modern enterprise development.
Long-term military career created Yan Xijun superb organization and management art and the commander of the strategic boldness, these talents in the business management practice has been the best play.
From 1996, the state vigorously promote the modernization of traditional Chinese medicine, the implementation of the international strategy, Yan Xijun keenly aware of this opportunity to the Chinese medicine enterprises to bring great potential for development and the formation of a strong impact on the Chinese medicine industry.
Yan Xijun clearly remembers the profound experience of visiting the United States with the enterprise delegation organized by the State Administration of Traditional Chinese Medicine. The long-term backwardness of China's pharmaceutical industry, so that the people of the country know little about the foreign pharmaceutical market. He thought, the United States is a country with high incidence of heart disease, compound danshen drip pills will have a market there. But when he arrived at the United States, he realized that in this highly developed economic powerhouse, how difficult it was for Chinese medicine to enter the mainstream market as a pharmaceutical product! At that time, there was not a Chinese medicine enterprise products can get in the U.S. Food and Drug Administration (FDA) certification, a few large enterprises of Chinese medicine products are as health care products or food in the Chinese district grocery store on the counter to sell. Yan Xijun brought with him the compound danshen drip pill, but few people ask for it.
This is a deep-rooted memory in Yan Xijun's heart!
The Chinese medicine is our national treasure, Japan, South Korea can take the "foreign Chinese medicine" in the world to make money, we Chinese why not? A strong sense of national pride and military mission inspired him, but also spurred him: revitalization of the sacred mission of Chinese medicine has historically fallen on the shoulders of our generation, if we can not put the Chinese medicine to the world, not only the ancestors, but also to the descendants!
Bearing this heavy sense of mission, Yan Xijun is actively looking for a good opportunity to enter the international market! The company is also accumulating the strength to enter the international market!
In the second half of 1996, the state in the national selection of excellent varieties of traditional Chinese medicine, the impact of the international market. Compound danshen drip pill in the many competing products, stand out. Yan Xijun immediately began to prepare the scientific research report, submitted to the U.S. FDA application to enter the U.S. market as a pharmaceutical product of Compound Danshen Drop Pills.
He chose another furrowed and thorny path for himself!
The reason why Chinese medicine is difficult to go to the international market is actually very simple. First of all, the cultural traditions of the East and the West are different, the basic theories of Chinese medicine, foreigners are difficult to accept, what "yin and yang", what "four qi and five flavors". In their view, the liver is the liver, the kidney is the kidney, where is the yin? Where is yin and where is yang? Invisible things are not recognized. Secondly, the "expression" of Chinese medicine is backward, in addition to the soup is a big pill, foreigners do not dare to eat. Thirdly, Western medicine is chemical, the ingredients are clear; while Chinese medicine is empirical medicine, which is based on the experience of our ancestors to find out little by little. As to how the disease is cured and which ingredient of the medicine works, there is no clear explanation. Fourth, herbs are mainly plants grown under natural conditions, even the same herb, due to different regions, different climates, different hydrological conditions, different planting management, the efficacy of the ingredients will be very different, with such herbs produced by the Chinese medicine preparations, the quality of which is very difficult to control.
What to do? Yan Xijun said, the road to go step by step, the fortress to be overcome one by one.
Yan Xijun is a person of great understanding. He is keenly aware that, thanks to the country's vigorous promotion, the modernization of traditional Chinese medicine will certainly appear a diversified development situation. He has a broad vision, active thinking, systematic thinking about the direction of the development of the traditional Chinese medicine industry. The modernization of traditional Chinese medicine production process has become the industry's **** knowledge. Based on the innovation of traditional Chinese medicine, he put forward the new concept of "modern Chinese medicine". Modern Chinese medicine is based on the theoretical guidance of traditional Chinese medicine, the application of modern advanced planting, extraction, separation, enzymatic and preparation technology, to remove the toxic components of herbs, with multiple active ingredients or multiple monomers composed of the active substance group formulations, the use of multivariate fingerprinting and chromatography technology qualitative, quantitative, and to meet the international standards of botanical drugs. According to this theory, Yan Xijun proposed "three innovations". First, process innovation, the development of advanced performance of the pill equipment, the process is fully automated, the use of advanced extraction technology to maximize the extraction of the active ingredients of Chinese herbs, to achieve the combination of modern pharmaceutical technology and traditional Chinese medicine theory; Second, the dosage form of innovation, we must change the backward traditional Chinese medicine, the traditional dosage form of the soup, the big pill, the use of advanced molecular dispersion technology, so that Chinese medicine to achieve the "three small". "three small" (small size, small dose, small toxic side effects), "three effects" (high efficiency, quick-acting, long-lasting) and "five convenient" (convenient production, convenient storage, convenient transportation, The third is the standard innovation, the use of high performance liquid chromatography and infrared spectroscopy and other advanced technology to monitor the quality of products, to achieve qualitative and quantitative analysis of Chinese medicine compound preparation, so that the quality of Chinese medicine, efficacy, safety and the world, to clear the obstacles for the entry of Chinese medicine into the international market.
In the process of researching and developing modern Chinese medicine, Yan Xijun strongly realized that the internationalization of Chinese medicine must create an integrated modern Chinese medicine industry chain that meets international standards. After rigorous investigation and systematic research, TIANSHILI built the first pharmaceutical source base in Shangluo, Shaanxi Province, which complies with the Good Agricultural Practice (GAP) for the cultivation and production of Chinese herbal medicines; took the lead in advocating and establishing the Good Agricultural Practice (GEP) for the production and quality management of modern Chinese medicines and extracts of botanical medicines; and pioneered the application of the world's first multivariate fingerprinting quality control technology for the whole process of drug quality control, which realizes the dual convergence of digitalization of modern Chinese medicines and world It is the first company in China to apply the international leading multivariate fingerprinting quality control technology to monitor the whole process of drug quality, realizing the digitalization of modern traditional Chinese medicine and the double convergence of the world's quality standard of plant medicine.
Pushing the traditional Chinese medicine industry into the era of modern industrial civilization and onto the advanced platform of modern manufacturing technology is Yan Xijun's unswerving belief. He was the first in China to put forward "to create a modern Chinese medicine advanced manufacturing digital platform", successfully developed the use of IT technology, intelligent control of the country's largest pill preparation and packaging production line. A modernized Chinese medicine production demonstration base in line with the modern Chinese medicine production quality management standard (GMP) was born. One hand is solidly building the foundation project of modernized traditional Chinese medicine, and the other hand is tightly grasping the international market. The market threshold of the United States is certainly high, but by no means insurmountable. A few years of trekking, investigation and exchange, Yan Xijun gradually feel the doorway into the U.S. pharmaceutical market.
In the following years, Yan Xijun traveled to and from the United States many times. In the spacious conference room in the U.S. FDA building, in the face of more than 20 picky U.S. pharmacy experts, scholars, Yan Xijun and his team of experts led by the bamboo, eloquent talk: "Chinese medicine as a cultural treasure of the world's medical treasure trove, in the past history of human health has made a great contribution. Now, as the process of modernization of traditional Chinese medicine continues to advance, we are willing to the best Chinese medicine products with the American people *** enjoy ...... "In the next defense, Yan Xijun on the efficacy of compound danshen drip pills, process, quality testing methods to answer all the questions of U.S. experts.
After conducting a series of audits, the U.S. FDA's approving officer solemnly declared: Permission is granted for Compound Danshen Dripping Pills to pass the U.S. FDA-IND application and enter phase II and phase III clinical studies! Yan Xijun listened carefully to the interpreter's retelling, he had not finished listening, was drowned out by a burst of enthusiastic applause ...... This scene, y fixed in Yan Xijun's mind, he was uplifted by this, he was proud of this, as if he broke through the ice of the harsh winter and saw the dawn of the spring of traditional Chinese medicine!
January 12, 1998, 18 ministries and commissions of the national new drug research and development coordination leading group held a working meeting in Beijing, officially announced that the Tianshili compound salvia pills to become China's first through the U.S. FDA-IND cardiovascular new drug clinical trials of the application of the compound proprietary Chinese medicines to achieve the national drug, "zero breakthrough! "
Yan Xijun's first success in the United States has strengthened his determination to develop the international market and promote Chinese medicine to the world. He wrote two ancient Chinese words into his motto: "The road is long, I will go up and down to seek", "where there is a will, there is a way". From then on, Yan Xijun, like an indomitable walker, began his journey to the world pharmaceutical market, his footprints throughout the five continents. On one side is the compound danshen drip pill into the FDA's work to unswervingly promote, in addition to technical standards and international standards, and more importantly, the human environment, the language way of convergence, which is a painstaking work; the other side of the general medicine of the international market development to be carried out in full swing. TIANSHI branches and offices have been established in more than ten countries, including France, Holland, Australia, South Africa, Central Africa, West Africa, Russia, Vietnam, South Korea and the United Arab Emirates. In April 2004, Yan Xijun wrote another brilliant stroke in the development history of TIANSHILI: TIANSHILI successfully grabbed more than 400 Chinese medicine granule batch numbers in the Netherlands, and entered the pharmaceutical market of 25 countries in the European Union in one fell swoop!
Tianshili not only pays attention to independent innovation, but also pays attention to the establishment of a sound intellectual property protection system, and has set up a whole set of protection measures, such as "core patents, peripheral patents and defense patents", to build an international famous brand.
Every Monday, when the golden sun rises from the horizon, the headquarters of TIANSHILI Group and TIANSHILI subsidiaries and offices around the world will hold solemn flag-raising ceremonies with the footsteps of the sun, and the five-starred red flag of China and the flag of TIANSHILI Group will be fluttering against the wind on the blue sky of foreign countries, which constitutes a bright landscape and gives each and every yellow son and daughter of the company a sense of pride. The flag of TIANSHILI GROUP is flying in the blue sky in foreign countries, constituting a bright scenery, which makes every Chinese citizen in the country feel heroic. In many countries, those consumers who have restored their health by taking TIANSHILI's modern traditional Chinese medicines, whenever they gather, "Long live China!" The laughter of "I love TIANSHI LIK" makes people y feel that China's "national medicine" has brought the gospel to the people of the world.
11 years of entrepreneurship, TIANSHILI all the way from the wind and rain, the total assets from the original 12 million yuan to 5 billion yuan, the staff from more than 40 people to 5,500 people, from a small factory covering an area of several acres of the development of 1,300 acres of modern traditional Chinese medicine city, from a flavor of traditional Chinese medicine to expand the industrial economy to a large health industry, the product covers the modern traditional Chinese medicine, chemical drugs, biological drugs, health care products and so on, the formation of a "big disease", "the big disease, the big disease, the big disease". The products cover modern traditional Chinese medicine, chemical medicine, biological medicine, health care products and so on, forming a product group of "big diseases, big varieties, big market and serialization". Compound Danshen Drip Pill is a record-breaking product, creating a miracle that the sales of a single variety of traditional Chinese medicine exceeded 1 billion yuan for four consecutive years. 2005, "TIANSHILI" was recognized by the State Administration for Industry and Commerce as a "Famous Trademark of China", and it became the first brand of modern traditional Chinese medicine. The company has been recognized by the State Administration for Industry and Commerce as "China Well-known Trademark" in 2005, becoming the first modern Chinese medicine brand.