Zhejiang Dade Pharmaceutical Group Co., Ltd
Zhejiang Dade Pharmaceutical Group Co., Ltd is a science and technology-based small and medium-sized enterprise in Zhejiang Province, an excellent enterprise in Jinhua City, and a high-tech research and development center in Jinhua City. The company has been awarded the Yiwu City Comprehensive Strength Award and the Contribution to Economic Development Award in successive years, and is a large taxpayer in Yiwu City.
Zhejiang Dade Pharmaceutical Co., Ltd. formerly known as Hangzhou Hu Qing Yu Tang Pharmaceutical Factory Yiwu Associated Plant, the Associated Plant was established in 1992, when the lease Yiwu City Refrigeration Plant by the housing 200 square meters as a plant, employees **** 8 people, the level of technology and production equipment is relatively obsolete, some of the main production equipment, such as tea packaging machines, rocking granulators, V-type mixer, Infrared dryer, pulverizer and so on are more backward. The production of the main products are heat bags, children's phlegm powder, lipid bags of tea, baby, winter skin spring ointment and other 5 varieties, annual output value of 300,000 yuan, belong to the small-scale production. December 9, 1997, the Provincial Department of Health and the Provincial Pharmaceutical Administration * * * with the following (Zhejiang Medical General Economic word [1997] No. 373), agreed to the joint venture with the decoupling of the Hu Qingyu Hall, and then renamed, transformed in Yiwu, founded Zhejiang Dade Pharmaceutical Co. Ltd. was founded in Yiwu, and the original production of five varieties of drugs, but also transferred to the new plant, in early 1998, Zhejiang Dade Pharmaceutical Co., Ltd. was formally established, Yiwu City, the pharmaceutical industry to achieve a zero breakthrough, in accordance with the State Council in 1996 under the relevant documents, the provisions of the new pharmaceutical companies, there must be a new drug of the second class, or two new drugs of the third class, and a new drug of the second class, worth A new drug of the second category is worth tens of millions of dollars, and a new drug of the third category is worth millions of dollars. At first, bought Hangzhou Hu Qing Yu Tang Yiwu branch of the right to operate, drug varieties and production equipment, the total *** value of 380,000 yuan.
After 6 years of development and growth of Zhejiang Dade Pharmaceutical Co., Ltd. in January 1, 2004 changed its name to Zhejiang Dade Pharmaceutical Group Co. At present, the company is located in Yiwu City Economic Development Zone, the transportation is very convenient. The company is located in Yiwu Economic Development Zone, with convenient transportation. The roads in the factory area are smooth, the road surface is leveled, the environment is elegant and the air is fresh. The construction of the company officially started in September 1998 and was completed in October of the following year, covering an area of more than 33,000 square meters, with a new plant of 10,000 square meters and a green area of 18,000 square meters, and the introduction of a number of production lines of tablets, dispersions, capsules, granules, oral liquids, sachets, and traditional Chinese medicine extraction with advanced level in the domestic market. The company has a product development department, production department, quality supervision department, engineering department, finance department, office, sales management department, GMP office and other functional departments and sales centers, the organization is set up reasonably and responsibilities are clearly defined. There are 1 general manager and 3 deputy general managers in charge of the company. The production workshop has two major workshops, namely, extraction workshop and preparation workshop, of which all the production workshops are equipped with domestic first-class equipments and have strong production capacity. The company has an annual production capacity of 50 million oral liquids, 200 million capsules, 30 million bags of granules and 200 million tablets. The company has first-class testing equipment and quality management system. The key instruments of the quality control department all adopt international famous brand products, meanwhile, the company effectively implements the internal control standard of quality, strictly controls the quality, from the purchase of raw materials to the after-sales service, each link carries out strict quality control, each employee has a high degree of quality consciousness and strong operation ability, in order to ensure that we consistently provide high-quality products and services.In December 1999, the company has all the five dosage forms, namely, tablets, capsules, granules, and pellets, successfully produced, In December 1999, the company's tablets, capsules, dispersions, granules, oral liquid five dosage forms all successfully passed the national drug production GMP dynamic certification, and became the first batch of the whole multi-dosage form of the dynamic certification of the national GMP pharmaceutical enterprises in Zhejiang Province. 2003, in the face of the impact of the "SARS", in order to provide more patients with preventive opportunities, the company has added a new production line of oral liquids, which is the first production line of oral liquid and tea production line. The oral liquid workshop and tea production line passed the GMP certification at the beginning of 2004. In mid-November, 2004, the company's existing six dosage forms of oral liquid, tablets, granules, capsules, dispersions, teas, etc. passed the national GMP re-certification inspection.
The company attaches importance to science and technology, people-oriented, and actively introduces professional and technical personnel, so that product development, production, inspection, supply and marketing links have a strong technical force. The company has 200 employees, 132 people with college or university education, accounting for 66% of the company's total number of people; 19 engineers and technicians, accounting for 20% of the total number of employees; 16% of technical titles; of which 4 senior technical titles, accounting for 2% of the total number of employees; intermediate technical titles 6 people, accounting for 3% of the total number of people; junior technical titles 18 people, accounting for 9% of the total number of employees. There are a group of pharmacy scholars who have been working in the pharmaceutical industry for many years and have rich theoretical knowledge and practical experience in the engineering and technical personnel. Company general manager Wang Jianguo realized the "way of employing people": recruiting and employing talents is not just a question of treatment, but the most fundamental is the quality of personnel; as a new enterprise, like a blank sheet of paper, to draw the latest and most beautiful picture, relying on the entrepreneurial spirit of the staff, especially the backbone; to sit back and enjoy the benefits of a higher diploma and a higher title, but not the same. If you want to enjoy the success, the higher the diploma and the higher the title will not help. With this concept, Dade prefers to introduce talents in the style of "becoming a boss from a wage earner". At the same time, let the introduced talents to the company to participate in the shares, become the master of the enterprise, their fate and future and the enterprise closely linked. In this way, the introduction of talent is the introduction of entrepreneurs, not only to retain him, but also to encourage him to make their own contributions to the enterprise. Dade also adopts the method of "directional attraction of talents", recruiting talents from the medicine schools of colleges and universities in Anhui, Jiangxi, Shaanxi, Heilongjiang and other places. From the establishment of the plant so far, has recruited more than 80 college graduates from Anhui and other places. 2000 introduction of college graduates, most of the key positions, the work is very promising. Drug production, is a high-tech, more need for national first-class professional and technical personnel. To this end, Dade hired a professor at Peking University, a doctoral tutor, the national Chinese medicine new drug reviewer Tu Pengfei and the director of the Beijing Institute of Natural Medicines, China's pCm expert group leader Leng Fangnan as a consultant. The "borrowed" high wisdom, high technology, speed up the introduction of drugs, development and research, and promote the take-off of the enterprise.
Products are the foundation of enterprise development, is the source of the rise and fall of enterprises. Without marketable and competitive products, the enterprise is like a fish without water and wood without soil, losing its vitality. 1999, at the beginning of the establishment of the factory, the company in the new factory, the situation of a thin base, it is more important to grasp the development of new varieties of research and development. The company uses the national GMP certified enterprises in the approval of new drugs, varieties of generic advantages, and actively organize the development of varieties of development, development, imitation work, to achieve the "selection of a, development of a, success of a, a profit". At the same time, set up a special leading group, division of labor, step up to improve the production process of fresh motherwort capsule, to ensure that the fresh motherwort capsule process is mature, stable production, as the company's fist product on the market. 2000, the company invested a lot of manpower and material resources in the development of new products, complete the ginkgo biloba long toxicity, acute toxicity, pharmacology, efficacy, clinical and other aspects of the study, and declared the ginkgo biloba, It has also declared the protection of traditional Chinese medicine for Ginkgo biloba, Fatigue-eliminating Granules and Milk Spring Punch, and has obtained the production license of Gallbladder and Stone Dispelling Bulk and the clinical approval of Kangweixin Oral Liquid. Among them, the fresh motherwort declared the national science and technology small and medium-sized enterprise innovation fund project and got 700,000 RMB gratuitous grant from the state, which injected new vitality into the enterprise.In June 2000, the Sage (Azithromycin granules) produced by the company passed the provincial new product appraisal in Hangzhou. This product is developed by the company in cooperation with Henan Zhengzhou Institute of Pharmaceutical Development, belongs to the national four types of new chemical drugs, is a new type of high-efficiency, long-lasting macrolide powerful anti-infective drugs in recent years with greater impact. In the appraisal meeting, Azithromycin granules won the unanimous praise from the experts, that its performance indexes are in the leading position among the similar products in China, and the production of this dosage form fills a blank in the province. At the same time, the company made full use of the advantages of national GMP-certified enterprises in the approval of new drugs, and invited relevant experts to carefully select more than 20 varieties with market development potential to declare up, and all of them were set up by the State Drug Administration, and became one of the enterprises with the largest number of set up projects in the national pharmaceutical industry in the year. To the second half of 2002, the completion of 20 projects to declare the information, and access to the Drug Administration production approval number. We won the financial support from the National Technology Innovation Fund for Small and Medium-sized Enterprises on the project of Fresh Motherwort Capsule. Fresh motherwort capsule is the new generation of gynecological medicine developed by the company in cooperation with Zhejiang Institute of Traditional Chinese Medicine, the project has applied for two national patents for protection, in order to cooperate with the production of this project, the company also established two fresh motherwort planting bases in the mountainous areas of Yiwu (the project has been included in the provincial torch program project by the science and technology system and has passed the acceptance). 2001 the company's ginkgo biloba dew by the Office of the Chinese Security Office was officially included in the national protection of traditional Chinese medicines varieties. In 2001, the company's ginkgo biloba was officially listed as a protected species of national traditional Chinese medicine by the Office of Chinese Medicine. Meanwhile, in the first half of the year, the company has also completed the declaration of a number of generic drugs, such as Yiqi Nourishing Blood Oral Liquid, Tongxin Oral Liquid, Four Seasons Sanhuang Tablet, Maiwei Di Huang Oral Liquid, Yangchun Yu Liquid, Diabetic Spirit Tablet, etc. The company has also completed the declaration of a number of generic drugs. Chinese medicine three kinds of new drugs Kang pulse heart oral liquid, Chinese medicine four kinds of new drugs fresh motherwort capsule data supplementation work, has now been issued by the State Drug Administration of the certificate of approval for the production of new drugs and new drug certificates. In addition, we have completed the phase III clinical trials of Anti-Virus Oral Liquid and Anti-Fatigue Granules, which are declared as national protected varieties of traditional Chinese medicines. In the second half of 2001, we completed the process improvement of Ganoderma lucidum granules, and improved Ganoderma lucidum granules with high sucrose content into lactose-type Ganoderma lucidum granules to enlarge the applicable population of the consumers and improve the compliance.In 2002, we declared the production of Kangweixin Oral Liquid, a new drug of the third category, based on the completion of the clinical research work, and we have obtained the certificate of approval of the production in 2003. In 2002, 1. Hepatocyte growth promoter capsule, a new drug of Class IV, was granted clinical approval and entered the clinical trial stage. 2. We obtained approval numbers for more than ten generic products, such as Yiqi Nourishing Blood Oral Liquid, Yangchun Yu Liquid, Four Seasons Sanhuang Tablet, Gastric Kangling Capsule, Mai Wei Di Huang Oral Liquid, Tong Wei Oral Liquid, and so on. Uricin Tablets, Rheumatism Capsules, and Laxative Capsules will also be approved for production.3. Completed the registration of generic products, such as Uricin Tablets, Liver Health Granules, and Azithromycin Capsules, among which Azithromycin Capsules are undergoing bio-equivalence test in cooperation with Jiangxi Medical College.4. Completed the research of Clinical Pharmacology & Efficacy of Niannian Chun Tablets, and Turtle & Deer Brain Health Tablets, which have now been declared to be registered and marketed in Hong Kong. 5. 5, complete the azithromycin granules process improvement work, and its process of patent declaration (has been accepted), modify the process declaration information has been reported to the State Drug Administration Registry. 6, motherwort capsule, fatigue particles of two products through the provincial level of new product identification. 7, efforts to do a good job of traditional Chinese medicine varieties of protection work, has been obtained antiviral oral solution, ginkgo biloba, fatigue particles of the Chinese medicine varieties of protection certificate. We have obtained the certificate of protection of Chinese medicine varieties. The protection work of Milk Spring Punch is also in progress. Completed the preliminary preparatory work for the protection of sugar-free Ganoderma lucidum granules as a traditional Chinese medicine (clinical trial). 8. "Preparation Method of a Pharmaceutical Preparation Hepatocyte Growth Promoting Vegetable Capsule", "Formulation and Preparation Method of a Pharmaceutical Preparation Rejuvenating Spring Tablet". 9, "Formulation and Preparation Method of a Pharmaceutical Preparation Guolu Brain Enhancement and Mind Tranquilizing Tablets", "Formulation and Preparation Method of a Pharmaceutical Preparation Kangweixin Oral Liquid", " Formulation and Preparation Method of a Pharmaceutical (Azithromycin Granules) "In 2004, we completed the application for registration of 8 products, the application for product development of 34 varieties of 7 categories, the application for patents of 5 varieties, the application for 9 projects, the application for the protection of 2 Chinese medicines, the application for the protection of 2 Chinese medicines, the application for the protection of 2 Chinese medicines, the application for the protection of 2 Chinese medicines, the application for the protection of 2 Chinese medicines, the application for the protection of 2 Chinese medicines, the application for the protection of 2 Chinese medicines, the application for the protection of 2 Chinese medicines, the application for the protection of 2 Chinese medicines, the application for the protection of 2 Chinese medicines. In 2004, we completed the application of 8 products R&D and registration, 7 categories and 34 varieties of products, 5 varieties of patent application, 9 projects, 2 varieties of traditional Chinese medicine protection, 6 varieties of OTC declaration and registration, 13 registered trademarks and trademark opposition.
Marketing is the leader of an enterprise and the key to its development. Under the condition of market economy, if an enterprise wants to survive and develop, it must take the initiative to adapt to the market economy, market-oriented, and strive to expand the market share of the products and improve the economic efficiency of the enterprise, otherwise it will be eliminated by the fierce market competition. 1998 when the company was founded, the company set up the sales department, open to the country to hire capable people with high salary to serve as marketing managers, and market promoters around the country, and to push the regional agency system, to establish a stable and stable marketing system, and to establish a stable and stable marketing system. In 2000, the company perfected the product marketing system, the sales department directly under the leadership of the general manager, fully responsible for the company's product sales, the company set up offices in major cities in Zhejiang Province, such as Hangzhou, Ningbo, Jiaxing, Shaoxing, Quzhou, Taizhou, etc., and outside the province in Beijing, Nanjing, Shandong, Tianjin, Chengdu, Wuhan, Jiangxi, Fujian, Guangxi and other areas, Jiangxi, Fujian, Guangxi and other regions have also set up offices or set up agents, and formed a set of marketing dynamic management system. The company also focuses on the development of future overseas markets, and actively contact with Thailand's Huanya Pharmaceutical Company and other organizations, ready to eliminate fatigue particles and other varieties of sales to Southeast Asia and other regions. At the same time also registered a sales company in Hong Kong (Hong Kong International Dade Pharmaceutical Co., Ltd.), for the products to enter the international market in the future to lay the foundation. At the same time, from 1998 to 2000, the company invested a lot of advertising costs, in 2001 and 2002, the company gradually increased the investment in advertising costs, in 2001 the annual investment of 5 million yuan of advertising costs, in 2002 the annual investment of 12 million yuan of advertising costs, so far the advertising costs have increased year after year. Has in zhejiang satellite television, zhejiang entertainment station, zhejiang education station, jinhua television, yiwu television on the product of advertising broadcast. The company firmly grasp the market dynamics, engage in market research, market analysis, and constantly collect information, from which the development of appropriate marketing strategies to adapt to market requirements, to better serve the market, so that the Dade brand y rooted in people's hearts, shaping the overall image of the enterprise.
In terms of enterprise production and operation, in the past six years, the enterprise's gross industrial output value (current price), industrial added value, sales value, profit and tax, profit, export delivery value, investment in technological reform and other data increased year by year, profit increased by 6 times, profit and tax increased by 109 times. It has made a significant contribution to the local financial income.
Yiwu Dade Herb Planting Co.
Yiwu Dade Herb Planting Co.
Yiwu Dade Herb Planting Co.
Yiwu Dade Herb Planting Co.
Yiwu Dade Herb Planting Co.
Yiwu Dade Herb Planting Co.
Yiwu Dade Herb Planting Co.
Yiwu Dade Herb Planting Co.
Yiwu Dade Herb Planting Co.
Yiwu Dade Herb Planting Co.
Yiwu Dade Herb Planting Co. There are two plots of land **** regulated by the company for planting, both of which are located in Yiwu City, where the company is located.
Nanwangdian planting base is located in the mountainous area of Fotang Town in the south of Yiwu City, adjacent to the Shuanglin Scenic Area, with beautiful scenery and convenient transportation, with sufficient land and water resources, which has been transformed into standard farmland, with good water conservancy measures, and with wild motherwort growing in the area all year round, which is suitable for planting fresh motherwort. The planting base has fresh air, no air pollution, no chemical factory, cement factory and other polluting enterprises, no harmful gas emission, no smoke and dust. The base is located in the upstream of the water source, and there is no pollution from production water and domestic water, and the water quality is pure. The soil is loamy to sandy loam, weakly acidic to neutral, with a fertile soil layer, which meets the requirements for fresh motherwort planting. The planting area is about 100 mu.
Dumen planting base is located in the mountainous area of Dachen Town in the northern part of Yiwu City, at the foot of Goofeng Mountain, a high peak in Yiwu City, which is easily accessible, with plenty of land and water resources, and wild motherwort growing all year round, which is suitable for fresh motherwort planting. The planting base has fresh air, no air pollution around, no chemical factory, cement factory and other polluting enterprises, no harmful gas emission, no smoke and dust. The base is located in the upstream of the water source, and there is no pollution from production water and domestic water, and the water quality is pure. The soil is loamy to sandy loam, weakly acidic to neutral, with a fertile soil layer, which meets the requirements for fresh motherwort planting. The planting area is about 50 acres.
Fresh motherwort capsule is the key product of Zhejiang Dade Pharmaceutical Group Co., Ltd, fresh motherwort capsule, compared with the traditional motherwort preparation, has wider functions, more accurate efficacy, more convenient to use, catering to the modern society's demand for green, natural and environmentally friendly medicines, and it can be used instead of the traditional motherwort preparation, with strong market competitiveness and the ability of exporting foreign exchange earning, and it is the only green medicine in the country. The company's annual output of fresh motherwort exceeds 800 tons, which can be processed to provide patients with medicines with exact efficacy.
Yiwu Dade Traditional Chinese Medicine Tablets Co., Ltd
Yiwu Dade Traditional Chinese Medicine Tablets Co., Ltd, which produces pCms for Dade Pharmaceuticals for the pre-treatment of Chinese herbal medicines and provides Chinese medicine tablets required for the extraction of Chinese medicines, covers an area of 3,000 square meters, with a building area of 2,500 square meters. Among them, the production area is 1050 square meters and the storage area is 1080 square meters. Greening area of 500 square meters. Practitioners *** there are 21 people, 15 people with secondary school education and above.
The environment around the tablets workshop is neat and tidy, the layout is reasonable, and the factory road is smooth. The production workshop is designed according to the requirements of the processing and concocting process of tablets. People flow and logistics are separated. The drug processing workshop is strictly separated from other processing and concocting operations. Strict quality assurance measures are taken in the production process. The storage conditions are good, and the functional areas are separated according to the regulations. To prevent errors. The workshop currently produces 421 varieties. The annual output of drinking tablets is more than 500 tons.
The Drinking Tablet Company*** has 14 personnel, including 4 technicians. All personnel have undergone comprehensive training in production technology. The production workshop of the tablet company has one deputy director of the workshop (presiding over the work), one technician, one QA clerk, one QC clerk and one administrator. The production workshop of tablets is directly under the production department of the company. The personnel engaged in the production management and quality management of tablets meet the requirements of acceptance standards. Personnel engaged in the operation of the production and quality inspection of the tablets are on duty after professional and technical training. Employees undergo annual medical checkups, and all those suffering from infectious diseases, skin diseases and trauma are transferred out of the jobs that are in direct contact with the tablets.
Plant and facilities: the production environment of the plant is clean and tidy, people and logistics are separated, the road surface is smooth, and the overall layout of the plant is reasonable. Production plant and traffic 50 meters away from the main road, the production workshop is built with tablets workshop, as well as power systems, sewage treatment systems, administrative offices. The plant is reasonably laid out according to the process flow to prevent insects, rats and flies from entering. The surface of the plant is smooth and easy to clean and disinfect. All the pipelines and water, electricity and other pipelines in the plant are concealed; the lighting in the main operation room is not less than 300 lux. Yiwu Dade Traditional Chinese Medicine Tablets Co., Ltd. is managed according to the clean area for the internal packaging position. Inside the plant, people and things are separated, and there are facilities for shoe changing, dressing, hand washing, disinfection and cleaning, which can effectively prevent pollution. The plant is equipped with security doors. The warehousing area is equipped with Chinese herbal medicine area, drinking tablets area, waiting for inspection area, qualified products area, unqualified products area, shipping area, drug store, fumigation room, etc., which is consistent with the requirements of acceptance standards. The quality management department has laboratories for biological testing, chemical testing, instrumental analysis, bacteriological testing and sample observation. The workshop has a workshop laboratory.
Equipment: The company's production equipment, public works equipment and quality inspection instruments and equipment, from the material, capacity, as well as cleaning, disinfection, operation and maintenance are adapted to the needs of the existing production of products and in line with the requirements of the acceptance criteria. Dust-producing posts such as crushing and purifying are equipped with dust removal devices and air supply and exhaust facilities. The precision of the instruments, meters, gauges and scales used for production and inspection have been calibrated by the statutory technical supervision departments and have clear status signs. The layout of equipment installation is compatible with the process flow, and the pipelines are painted in accordance with the relevant regulations, with contents and flow direction signs. The company is equipped with fire extinguishing devices and safety doors in strict accordance with national requirements.
Material management: according to the different materials, the storage in the tablet workshop is divided into raw material area, auxiliary material area, finished product area, drug warehouse, packaging material warehouse and so on. In order to ensure the quality of tablets, raw materials, auxiliary materials, packaging materials, such as purchase, use of materials are formulated management system, and in line with national drug standards. The cargo spaces for raw and auxiliary materials and packaging materials to be tested, qualified and unqualified are strictly separated and have obvious status identification markings. Unqualified raw and auxiliary materials and packaging materials are guaranteed not to be put into use; unqualified semi-finished products and intermediates are guaranteed not to flow into the next process; and finished products that do not meet the quality standards are not shipped out. Toxic herbs are stored in special libraries and managed with double locks. The net herbs after processing and concocting are stored in clean containers. The original medicinal materials, auxiliary materials and finished products are formulated with storage period and re-inspection system. Unqualified materials and waste are handled in accordance with the prescribed procedures.
Production management and quality management: A complete set of production management and quality management documents have been established and perfected according to the actual situation of the production of tablets. The production process operates in an orderly manner according to the requirements of acceptance standards, each batch of products is fed according to 100% of the prescribed quantity, and the key processes are set up for review and QA supervision and inspection. The formulation and modification of process protocols and job operation methods are subject to drafting, review and approval procedures. Each product is organized according to the formulated technology regulations and job operation law. Personal hygiene, production plant and equipment clean, strict implementation of the health management system, the inner packaging room is managed according to the clean area. Each batch of products have a batch production records reflecting the actual production situation in line with the requirements of the acceptance criteria, batch records are archived and kept for three years, and the batch records of toxic varieties are archived and kept for five years. Different products are not produced in the same operation room at the same time, and each production operation room and production equipment and containers are marked with the status of the products being processed. The washing of herbs is done with flowing water, and the used water is discharged and cleared in time. Different herbs are not washed in the same pool at the same time. The production workshop and the main production equipment are marked with status symbols. After the completion of each production stage of each batch of products, the site is cleared and the record of clearing is filled in. Quality Supervision Department is responsible for the quality supervision of the whole process of drug production, directly under the leadership of the general manager. Quality standards and inspection procedures for raw herbs, auxiliary materials, packaging materials and tablets have been formulated for each variety of products. The quality inspection instruments are complete and advanced, with the ability to fully inspect the Chinese herbal medicines, intermediate products and finished products. All the tablets have factory inspection reports.
Yiwu Dade Traditional Chinese Medicine Drinking Tablets Co., Ltd. will spare no effort to make continuous improvement and endeavor to raise the standard of our work to produce high-quality drinking tablets to serve the patients and the society.