What is the toxicity of DMSO? I have seen two very different versions on the internet, is there any fellow molecule maker to answer this~~~

I think the problem you mentioned can be analyzed from the point of view of different grades (or purity) of the same reagent or drug, and can not be generalized, I hope that the following information can help you:

Dimethyl Sulfoxide

Molecular Formula: (CH3)2SO (abbreviation DMSO)

Molecular Weight: 78.13

Boiling Point: 189(760mmHg) Crystallization Point: 18.45 Specific Gravity: 1.1014(20)

Flash Point: 95 Flash Point: 304

Specific Heat Capacity: 2.93J/(Kg-°C)(Liquid)

Specification: Superior Grade, Pharmaceutical Grade, Spectroscopic Grade, Food Grade, Electronic Grade.

Properties: a transparent, colorless, odorless, slightly bitter liquid with very low toxicity. It is a water-soluble compound that can dissolve most organic compounds, even for inorganic salts. Liquid dimethyl sulfoxide can be highly conjugated. It is a polar solvent with strong water absorption and permeability to the muscle. Pure product has no corrosion on metal, containing water has slight corrosion on iron, zinc, copper. Stable nature, long time in the boiling temperature of heating trace decomposition in the alkaline state can inhibit corrosion or decomposition.

Uses: used as a solvent for organic synthesis of pesticides, dyes, pharmaceutical intermediates, etc.; aromatics extraction, spandex spinning polymer polymerization, paraffin wax refinement, diesel refinement, electronic component cleaning, gas absorption, rare metal extraction solvent; capacitor media antifreeze, hydraulic fluid raw materials; chemical reaction accelerating solvents; pesticides, fertilizers, pharmaceutical effect agent. It is anti-inflammatory, analgesic, sedative, diuretic, and promotes wound healing; and other drugs dissolved in it can be infiltrated into the body through skin coating, instead of oral intake or injection. Used in the treatment of arthritis, dermatitis, foot fungus, psoriasis, sprains, tumors and other diseases. Therefore, it is named "universal medicine" or "universal solvent".

Storage and transportation: airtight, sunscreen, waterproof, crystallization below 18.

I. DMSO Product Introduction

1) Industrial grade - DMSO use: mainly used in anhydrous organic chemical synthesis reaction and pharmaceutical and intermediates synthesis reaction solvent, the use of the solvent can improve the speed of chemical reaction, improve the yield of reactants, shorten the reaction time, so that the synthesis reaction becomes more smooth.

Industrial grade-DMSO quality and technical indicators

Item Indicator Implementation standard

Content (in DMSO) %: ≥ 99.8 GB/T2307-1986

Crystallization point ℃: ≥ 18.10 GB/T7533-1993

Acid value (0.1N/ml NaOH/50g): 0.1N/ml NaOH/50g. Acid value (0.1N/ml NaOH/50g): ≤ 0.01 GB/T9736-1988

Moisture %: ≤ 0.1 GB/T6283----86

Evaporation residue PPM: ≤ 5. GB/T3209----82

Heavy metal %: ≤ 10. GB/T7532----87

Packaging PE plastic drum 225kgs, 100kgs, 50kgs, 25kg

2) Pharmaceutical grade-DMSO Usage: It is mainly used as a reaction solvent for synthesis of pharmaceuticals and intermediates, pharmaceutical solvent and carrier of drugs, etc. The use of this solvent can increase the speed of the chemical reaction and the yield of the reactants.

Pharmaceutical grade-DMSO quality and technical indicators

Item Indicator Execution standard

Content (in DMSO) %: ≥ 99.9 GB/2307-1986

Crystallization point ℃: ≥ 18.3 GB/T7533-1993

Refractive index: 1.478~~1.479 GB/T6488 1.479 GB/T6488-1986

Moisture %: ≤ 0.01 GB/T6283-1986

UV extinction value: 275nm ≤ 0.3 GB 9721-1988

285nm ≤ 0.2

295nm ≤ 0.2

Heavy Metal PPm: ≤ 10 GB/7532-1987

Specific gravity (20℃): 1.100-1.104 GB/4472-1984

Acid value (0.1N/ml NaOH/50g): ≤ 5.0 GB/9736-1988

Packing: PE plastic drums 225kgs, 100kgs, 50kgs, 25kgs

Packing: PE plastic drums 225kgs, 100kgs, 50kgs, 25kgs, 25kgs. 25kgs

3) Anhydrous grade-DMSO use: mainly used for pharmaceutical and intermediates synthesis reaction solvent, pharmaceutical solvents and drug carriers, etc., the use of the solvent can improve the chemical reaction speed, improve the yield of reactants

Anhydrous grade-DMSO quality and technical indicators

Item Indicator Implementation standard

Content (in DMSO) %: ≥ 99.9 GB/2307---1986

Crystallization point ℃: ≥ 18.35 GB/T7533-1993

Acid value (mgKOH/g): ≤ 0.001 GB/T9736-1988

Refractive index (20℃): 1.478 -1.479 GB/6488---1986

Moisture %: ≤ 0.001 GB/6283---1986

Evaporation residue PPM: ≤ 5. GB/T3209----82

Heavy metal %: ≤ 10. GB/T7532----87

Packing: PE plastic drum 225kgs,100kgs,50kgs,25kgs

4) Topical medicine-DMSO use: DMSO itself has medical effects, play a pain, swelling, bruising, also has a special effect on skin diseases. 295nm ≤ 0.2

Heavy metal PPm: ≤ 10 GB/7532-1987

Specific gravity (20℃): 1.100-1.104 GB/4472-1984

Acid value (0.1N/ml NaOH/50g): ≤ 5.0 GB/9736-1988

Packing. PE plastic drum 225 kgs, 100kgs, 50kgs, 25kgs

5) Reagent grade-DMSO Usage: DMSO is used as a solvent for liquid chromatography, and also used as a reference for testing the UV extinction value of the substance when it exists in liquid form.

Reagent grade-DMSO quality and technical indicators

Item Indicator Execution standard

Content (in DMSO) %: ≥ 99.9

Acid value (MEQ/G): ≤ 0.001

Moisture %: ≤ 0.10

Evaporation residue %: ≤ 0.01

UV extinction value: ≤ 0.01

Reagent grade-DMSO is used as liquid chromatography solvent, and also used as a reference when testing substances on the UV extinction value. p>

UV extinction value: 356-400nm, ≤ 0.010

330nm, ≤ 0.02

310nm, ≤ 0.06

290nm, ≤ 0.18

270nm, ≤ 0.46

Packing: PE plastic drums 225 kgs, 100kgs, 50kgs, 25kgs, 25kgs. 50kgs,25kgs

Carbon disulfide

Uses: The product is used for viscose fiber, cellophane, rubber accelerator, pesticides, metal flotation agent is the main raw material, is sulfur, phosphorus, iodine rubber and paraffin wax good solvents, but also can be directly used as insecticides and fumigants, etc., the best products used in the pharmaceutical industry. The best products are used in pharmaceutical industry. The refined products are used as anti-corrosion additives for aviation kerosene.

Quality index (in accordance with GB/T 1615----94)

Appearance: colorless and transparent

Density: (20℃)/(g/mL): 1.262~1.267

Fractionation rate (45.6~~46.6℃, 101.32kpa) (ψ)/%: ?"97

Evaporation Residual value, %: ≤0.007

Packing: Aluminum drums or trucks.

Note: Carbon disulfide is flammable and explosive

Dimethyl sulfide

Uses: It is an intermediate product in the production of dimethyl sulfoxide, which can be used as an organic solvent in the process of polymerization, cyanide and other organic synthesis as organic solvents, and it is a textile solvent for synthetic fibers such as polypropylene acrylic. In addition, it can be used as industrial purification agent, paint release agent, hydraulic oil solvent, battery low temperature anticorrosion agent and drug penetration agent.

Quality index:

Content ≥99%

Moisture <1%

Packing: Iron drum, or car tanker transportation.

Note: Dimethyl sulfide is flammable and explosive, storage and transportation are treated as poisonous goods