What is carcinoembryonic antigen testing?

Question 1: What is the significance of quantitative detection of carcinoembryonic antigen? Carcinoembryonic antigen is a broad-spectrum tumor marker, which can reflect the existence of various tumors to people. It is a good tumor marker to judge the curative effect, disease development, monitoring and prognosis of colorectal cancer, breast cancer and lung cancer, but its specificity is not strong, its sensitivity is not high, and its effect on early diagnosis of tumors is not obvious. Carcinoembryonic antigen (CEA) was originally found in colon cancer and fetal intestinal tissue, hence its name. The increase of serum CEA is not only found in digestive tract tumors, but also in other systems. The quantitative detection of carcinoembryonic antigen has the following three meanings: 1. Continuous monitoring of carcinoembryonic antigen level can be used to observe the curative effect of tumor treatment and judge the prognosis. In general, the determination of CEA is mainly used for clinical monitoring of colorectal cancer, gastric cancer, pancreatic cancer, hepatocellular carcinoma, lung cancer, breast cancer and medullary thyroid cancer, but it is also found in choriocarcinoma, bone cancer, prostate cancer and ovarian cancer, but it has no early diagnostic value. In addition, slight increase of CEA was also found in some benign digestive tract diseases such as intestinal obstruction, biliary obstruction, pancreatitis, cirrhosis, colonic polyps, ulcerative colitis, smokers and the elderly. In these patients with benign diseases of digestive tract, 25% patients' serum CEA can increase with time. The level of serum carcinoembryonic antigen decreased when the condition improved and increased when the condition developed. 45-80% of patients with primary colon cancer have increased CEA. In addition to primary colon cancer, there are adenopancreatic cancer, cholangiocarcinoma and gastric cancer. The positive rate of esophageal cancer, adenocarcinoma, lung cancer, breast cancer and urinary system tumor is also very high, generally at 50-70%. 2. The determination of 2.CEA can be used as a basis for differential diagnosis of benign and malignant tumors. CEA in patients with benign tumors, inflammatory diseases and degenerative diseases such as colonic polyps, ulcerative colitis, pancreatitis and alcoholic cirrhosis is also partially increased, but it is much lower than that in patients with malignant tumors, generally less than 20μ g/L. When CEA exceeds 20ng/mL, it often indicates that there is a digestive tract tumor. Carcinoembryonic antigen is an acidic protein. The content of CEA in normal mucosa adjacent to cancer is very low or negative. The positive rate of CEA in gastric cancer was 85.58%. Among them, mucinous adenocarcinoma and signet ring cell carcinoma (mucinous cell carcinoma) were 100%. Under the electron microscope, it was found that CEA was distributed in protein synthesis and transport organelles (such as nuclear membrane, endoplasmic reticulum, Golgi apparatus and its secretory vesicles) in the cell membrane and cytoplasm of cancer cells, suggesting that cancer cells synthesized more CEA, so CEA entered the glandular cavity also increased. Because CEA is located in the sugar envelope around the cell membrane and is easily released into the surrounding body fluids, the concentration of CEA in body fluids and gastric juice is higher than that in serum.

Question 2: How much does it cost for normal people to detect carcinoembryonic antigen? Analysis: Hello, my friend. Carcinoembryonic antigen (CEA) is a proteoglycan complex existing in colon cancer, normal embryonic intestine, pancreas and liver. Guidance: Hello, the normal value of carcinoembryonic antigen (CEA) is ≤ 5 ng/ml. Your test value is 8.23, which is slightly higher than normal, but you can't diagnose cancer on this basis. It is recommended to review, and pathological examination is needed to diagnose cancer.

Question 3: What do you think of the results of carcinoembryonic antigen? According to statistics, every subject who comes to a celebrity physical examination will take the initiative to add tumor screening, and the most common one is carcinoembryonic antigen detection. Carcinoembryonic antigen (CEA) is a component produced by normal embryonic tissues, which gradually disappears after birth, or only a very small amount remains. When cells become cancerous, the expression of this antigen will increase significantly. Therefore, it is often used for broad-spectrum screening of cancer cells, but recently many subjects said that although carcinoembryonic antigen was detected, they were puzzled by the test results. To this end, celebrity health experts explain one by one: what is carcinoembryonic antigen? Colorectal cancer tissue can produce a glycoprotein, which can be used as an antigen to cause immune response in patients. This antigen is called carcinoembryonic antigen, which can be widely found in digestive system cancers originating from endodermal leaves, in digestive tract tissues of normal embryos, and also in trace amounts in normal human serum. CEA was originally found in colon cancer and fetal intestine, hence the name carcinoembryonic antigen. Elevated CEA is common in colorectal cancer, pancreatic cancer, gastric cancer, small cell lung cancer, breast cancer and medullary thyroid cancer. However, 15% ~ 53% of patients with smoking, pregnancy and cardiovascular diseases, diabetes, nonspecific colitis and other diseases will also increase their serum CEA, so CEA is not a specific marker of malignant tumor, but only has auxiliary diagnostic value. In addition, the serum CEA level is obviously related to the staging of colorectal cancer. The more serious the lesion, the higher the CEA concentration. Many people look at the high value in the report and worry about whether they have some kind of cancer, but experts suggest that a high value does not mean that there must be tumor cells. Experts suggest that the best way is to do a comprehensive anti-cancer series physical examination or the results of dynamic detection of carcinoembryonic antigen. If it is serious, consult the relevant oncologist. Anhui physical examination experts warmly suggest that carcinoembryonic antigen is a broad-spectrum tumor marker, which can reflect the existence of various tumors to people. It is a good tumor marker to judge the curative effect, disease development, monitoring and prognosis of colorectal cancer, breast cancer and lung cancer, but it is not specific and sensitive, and has no obvious effect on early diagnosis of tumors.

Question 4: What does it mean to detect serum carcinoembryonic antigen? You don't have to worry about it, and you don't have to review the carcinoembryonic antigen results. Don't test this item in the next physical examination, because there is no way to react in the early stage of cancer, and it is accurate in the late stage of cancer. If you are afraid of stomach cancer, you can do a gastroscope to find the early stage. I can't ask clearly.