The former Soviet scholar Obalin put forward the total hypothesis.
His experiments show that if protein, polypeptide, nucleic acid and polysaccharide are put into a suitable solution, they can be automatically concentrated and aggregated into dispersed spherical droplets, which are aggregates. Oberlin and others believe that aggregates can show life phenomena such as synthesis, decomposition, growth and reproduction. For example, the aggregate has a boundary similar to a membrane, and its internal chemical characteristics are significantly different from the external solution environment. Agglomerates can absorb some molecules from the external solution as reactants, and can also undergo specific biochemical reactions under the catalysis of enzymes, and the products of the reactions can also be released from the agglomerates.