According to the needs of the topic used in 23andMe, it is called ancestor composition, and Chinese is temporarily called ancestor composition. Its fundamental logic is that no modern society is a pure group of people, but a mixture of several nationalities. Use large-scale data and ancient human DNA data, supplemented by machine learning algorithms such as Bayesian or support vector machines.
You can infer the proportion of each ethnic group in a person's genome. This calculation requires a lot of data. According to UCLA's hybrid software, the number of loci to be detected is generally not less than 65,438+0,000 polymorphic loci, and people in continents should be distinguished.
For example, in China and Japanese, the number of polymorphic loci detected is generally not less than 65438+ million; If we want to further distinguish different populations in China, such as southern Han nationality, northern Han nationality, ethnic minorities and so on, the number of polymorphic loci needed will further increase. Therefore, most of the data generated by so-called genetic testing in the market, especially in China, cannot be used for this analysis.
What ordinary consumers can buy can be used for ancestral component analysis services, and unofficial information may be somewhat fallacious:
1.BGI personal genome service: complete exon sequencing service, professional interpretation service for rare mutations, and ancestor analysis report, which are expensive. Please contact BGI's local sales or agents to buy.
2.23andme et al. Are chip inspection services headquartered in Qualcomm, USA, providing first-class reports on ancestral components with user experience. But the disadvantage is that you need to go to Haitao, and the entry and exit of samples is more troublesome. Please go to omnipotent Taobao to buy. ?
3. Source Gene: A genetic testing company, with Mr. Yan Yan, a teacher from Fudan University, as a scientific consultant, specializes in testing and analysis services related to ancestral sources.
4.BTW: The services provided by the Shanghai Anthropology Society do not include the services of ancestral component analysis, but only the interpretation services of Y chromosome haplogroup and MT chromosome haplogroup.
5. Stakeholder: WeGene co-founder.