For this disease at the forefront, people will panic at the slightest sign of trouble. A recent online article claimed that American scientists admitted that cancer cells spread faster after surgery or radiotherapy and chemotherapy. Isn't surgery or chemotherapy a common method to treat cancer? How did it backfire? Is this statement true?
The sensational title is shocking.
?
If you want to know the ins and outs of things, you must first be familiar with relevant knowledge.
Cancer refers to malignant tumor, and the main treatment methods are surgery, chemotherapy and radiotherapy. Among them, surgical resection is suitable for local treatment and more thorough. However, once cancer occurs, it will be difficult for cancer cells to shed and proliferate through blood vessels and lymphatic vessels and transfer to the surrounding area. It will still recur after this operation, so it is not realistic to cure cancer across the board.
At this time, chemotherapy or radiotherapy is needed, in which chemotherapy is divided into systemic chemotherapy, adjuvant chemotherapy and salvage chemotherapy. Clinically, radiotherapy and chemotherapy can destroy or destroy cancer cells and even cure some tumor patients. However, these two methods will bring great pain to patients. While inhibiting and killing cancer cells, they will also have side effects, which will do harm to normal cells and body functions. Some chemotherapy drugs will also cause allergic reactions, drug-induced fever and other problems, while radiotherapy will cause great damage to local tissues of patients.
? Is radiotherapy and chemotherapy harmful to human healthy cells? This is really no problem. So, will radiotherapy and chemotherapy trigger the spread of cancer cells?
As mentioned in the original text, the spread of cancer cells is caused by a disease called TGF? Material-induced, American scientists have done experiments on mice and found that mice with breast cancer have TGF-? It is this substance that stimulates cancer cells to metastasize to the lungs.
But this does not mean that radiotherapy and chemotherapy will lead to the spread of cancer cells.
TGF-？ Its Chinese name is transforming growth factor-? (? Transforming growth factor β) is a multifunctional cytokine and an endogenous substance existing in human body. Studies have shown that it not only inhibits tumors, but also promotes tumors. When fighting cancer, TGF-? It can inhibit cell proliferation, induce cell apoptosis and inhibit the expression of inflammatory factors and cell growth factors. But it can also interfere with cell cycle, promote epithelial interstitial cells or epithelial interstitial cells, induce angiogenesis, increase protease expression and extracellular matrix deposition, and then promote the occurrence of cancer. So, TGF- It is a swing, and the anti-cancer position is not firm. Studies have shown that TGF- It is still seriously carrying out the task of inhibiting the proliferation of precancerous cells, but in the middle and late stages of cancer, it began to help others and help tumor migration.
Scientists have always been interested in TGF? The dual role of research. It regulates the development of tumor, and people want to know its mechanism, so as to stimulate its anti-cancer effect and shield its anti-cancer effect. However, the progress is very slow, and these studies are only seen in theory, not applied to clinic, but aimed at TGF-? In our study, there is no correlation between surgery and chemotherapy and cancer metastasis.
What's more, this article reprinted a report of Xinhua News Agency on April 9, 2007. From 2007 to now, the medical circles at home and abroad have never stopped using surgery or radiotherapy and chemotherapy to treat cancer. What can we learn from it?
As for the choice of treatment, it depends on the patient's condition. Whether it is chemotherapy or radiotherapy, the decisions made by doctors are well thought out. For example, for advanced patients, if the expected survival time is short, there is no need to receive endless radiotherapy and chemotherapy, which will only increase the pain. For example, liver cells are not sensitive to chemotherapy drugs, so chemotherapy is not recommended for most liver cancers except for rare special liver cancers such as cholangiocarcinoma.
Surgery, chemotherapy and radiotherapy are still the three major means of cancer treatment.
?
Cancer treatment still needs more doctor's advice.
Off-topic, we all know that malignant tumors have strong metastasis and infiltration ability to adjacent normal tissues and are difficult to deal with. It is of great significance for patients if it can be judged early whether it has metastasized. TGF can help us do this. At present, some articles show that it can be used to detect patients who have surgically removed tumors and determine whether cancer cells have metastasized.
References:
Transforming growth factor TGF-? Role of tumor microenvironment, Yang Yuan, Xu Jingyu, Wen, Duo Biguang, Journal of Zunyi Medical College, 2013-02-28;
?
?
The copyright of the content signed "Tadpole Staff" belongs to Tadpole Staff, and any media, website or individual may not reprint it without authorization, otherwise the corresponding legal responsibility shall be investigated. Please send an email to editor@kedo.gov.cn to apply for reprinting authorization or cooperation. The signed articles published on this website only represent the author's views and have nothing to do with this website. If there is any infringement, you are responsible.
Author: Zhang