Experimental mice used in experiments are generally healthy, and experiments cannot be carried out without health. But healthy mice don't mean they have no germs in their bodies. Because bacteria need to reach a certain number in the body to cause disease.
The toxin of puffer fish is produced by its poison glands, but it can only be produced after the poison glands develop to a certain extent. The mechanism of producing poison glands is innate, which means that this mechanism can be passed down from generation to generation.