The dysplasia of corpus callosum is mostly sporadic, and the reason is unknown. Its clinical symptoms and somatic symptoms are related to other brain malformations, because congenital agenesis or absence of corpus callosum itself generally does not produce symptoms. In adult patients, with complex psychometric examination methods, it can be found that there is a slight obstacle in information transmission between the two hemispheres. Corpus callosum dysplasia can exist alone, even without any symptoms, but this situation is very rare.
Most children with this disease will have some appearance abnormalities, such as too big or too small head, too small chin, squint, cataract, or too small eyeball, cleft lip and palate, abnormal kidney and ureter, polydactyly or syndactyly, etc. Most people suspect that the abnormal situation of children may be caused by hydrocephalus, and then carry out computerized tomography to find out the characteristics of dysplasia or absence of corpus callosum.
The dysplasia of the corpus callosum may lead to mild mental retardation or mild visual impairment or cross-tactile localization disorder. Severe mental retardation and epilepsy may occur. Hydrocephalus can lead to increased intracranial pressure. Babies often have spasms and pyramidal signs.
X-4 sex-linked inheritors are characterized by seizures and severe developmental delay within a few hours after birth.
Although corpus callosum dysplasia has been formed in the fetal period, there is no characteristic to tell us that babies suffer from this disease after birth. It is often in the process of baby's development that there are nervous system symptoms such as slow movement or language development, epilepsy (especially baby nodding spasm) or cerebral palsy. This situation is found by brain ultrasound or brain magnetic resonance scanning. If there is any possibility, the baby's appearance deserves our suspicion of corpus callosum dysplasia. If the eyes are too far away and squint, we should be alert to the possibility of this disease. The vast majority of cases have abnormal neurodevelopment, often accompanied by motor and language retardation, mental retardation, epilepsy and cerebral palsy.