Malignant brain tumor is a health killer and its initial symptoms are not obvious. Headache is one of the main symptoms. Dr. Lin Xinrong, Chairman of Taiwan Province Neurosurgery Medical Association and Dean of Beigang Mazu Hospital, pointed out that malignant brain tumor has always been regarded as an incurable disease. Although there are about 600 new cases of primary malignant brain tumors in Taiwan Province Province every year, accounting for 1% of all malignant tumor cases, the mortality rate is extremely high. According to the clinical experience of the medical community, most patients will not live 1 year only by traditional treatment methods such as surgery.
Traditional drugs have great side effects.
At present, there are three methods to treat malignant brain tumors in medicine: surgery, radiotherapy and chemotherapy. Chemotherapeutic drugs paid by medical insurance include nitrosourea agents, oral drugs and drug chips. Although there are many kinds, most of them have side effects, among which brain swelling, intracranial wounds are not easy to heal and brain pressure is easy to rise.
Take the most malignant glioblastoma multiforme as an example. Cancer cells grow along nerve fibers and spread like octopus claws. Even if the tumor visible to the naked eye is removed by surgery, 75% has metastasized to other brain lobes, and the risk of death is higher.
Taiwan Province homemade drug chip
Traditional Chinese medicine classics list Angelica sinensis as a non-toxic top-grade drug, which can enrich blood and promote blood circulation, and some elements can alleviate tumor inhibition. (This website photo/information) It is precisely because of the terrible lethality of malignant brain tumors that the Taiwan Province Neurosurgery Medical Association actively invested in the research and development of new drugs, and formed a research and development team of 20 people with Cai Hongzhi, a professor of pathology at China Medical University, Qiu, a professor at Donghua University, and 10 doctors, hoping to find a solution. At present, angelica sinensis is listed as non-toxic medicine in Chinese medical classics, which can enrich blood and promote blood circulation, regulate menstruation and relieve pain, moisten intestines and relieve constipation, and has an inhibitory effect on the treatment of brain tumors in clinic.
In animal experiments, it is proved that the z-BP substance in Angelica sinensis can be extracted and alcoholized, and then the NUR77 gene can be targeted, which can effectively destroy the mitochondria of brain tumors, narrow the tumor range, improve the survival time, and achieve the therapeutic purpose of more than half a year.
Target new drug being applied for
The new treatment method is mainly to control the "slow-release chemical chip" to put drugs into the brain tumor area. In animal experiments, it was found that the size of malignant tumor in mice decreased by 64% after 3 weeks, and the average life expectancy doubled. Based on the results of this animal clinical trial, we will apply to the US Food and Drug Administration (FDA) for human clinical trial. If all goes well, it is expected that new drugs will come out in the future to benefit patients with brain tumors.