The National Institutes of Health solved the mystery of longevity, and the immortal gene froze the age of mice.

Can people really live forever? The National Institutes of Health and Yangming University cooperated in animal experiments, and it was found that if the longevity gene "Cisd2 protein" could be continuously expressed during the aging process, the life span of mammals could be prolonged, the aging could be slowed down, and mice could be healthy to the old age. The research team, including the researcher jointly hired by the Institute of Molecular and Genetic Medicine of the National Institutes of Health, the postdoctoral researcher Cai Tingfen of Chen Yifan and the cooperative team of Yangming University, confirmed through animal experimental evidence that the expression of "Cisd2 gene" directly affects the life span of mammals. In 200 1 year, Harvard University in the United States analyzed more than 100 long-lived families and found that there may be genes that determine human life span on the long arm of human chromosome 4. While sequencing the fourth chromosome to find genes related to liver cancer, Yang Rong's team discovered a new gene (Cisd2) located in this long-lived chromosome region. Interestingly, Cisd2 is highly conserved in evolution, and all organisms from low (such as flies) to high (such as humans) have this gene. In 2009, Dr. Cai Tingfen's research team proved for the first time that "Cisd2 protein" is mainly located in the outer membrane of mitochondria, which plays an important role in increasing cell energy metabolism and exerting mitochondrial function, thus affecting the life control of mammals. The latest research shows that in the absence of Cisd2, the knockout mice begin to suffer from premature aging in 4 ~ 8 weeks (about 15 ~ 25 years old), including a series of aging phenomena such as neuromuscular degeneration in the early stage, blurred vision, gray hair, osteoporosis and skin relaxation in the later stage. Clinically, during the aging process of normal mammals (such as mice), the expression of Cisd2 gene will decrease with the increase of age. Dr. Cai's team used gene transfer technology to keep a certain amount of Cisd2 protein expression in mice from adolescence, middle age to old age. The results showed that as long as the expression of Cisd2 protein in the old transgenic mice was not reduced, the aging could be obviously slowed down, and the average life span of the whole system was prolonged as that of the young mice. In addition, Cisd2 protein also has the ability to alleviate the symptoms related to skin, muscle and nerve aging. In addition, Cisd2 protein also has the function of protecting mitochondria and avoiding aging-related damage and functional loss. Cai Tingfen pointed out that the results of this study show that "Cisd2" plays a very important role in life control, and the results of animal experiments also provide a strong research basis for discussing the correlation between Cisd2 and human life span. Subscribe to the health Aloha audio-visual channel, read health knowledge more easily, and pay attention to your health every day! Line @ ID: @:/supply/article/5954/National Institute of Health solves the mystery of longevity; Immortal gene frozen mice; Key words: experiment, aging, longevity, National Institutes of Health