Borane complex of amine of borane dimethyl sulfide

Generally, trivalent nitrogen atoms in amine molecules have stronger electron donating ability than divalent oxygen and sulfur atoms, so the complexes formed with electron-deficient borane are relatively stable, which gives these reagents some special uses. For example, dimethylamine borane and morpholine borane can be used as reducing agents for electroless plating (copper plating, nickel plating, chromium plating, gold plating, silver plating, palladium plating, platinum plating, rhodium plating, iridium plating, etc.). ) Under neutral or alkaline conditions, it has been widely used and produced hundreds of tons abroad. Electroless plating of boron reagent has also been widely carried out in China. The application of borane complex has the advantages of good surface finish and outstanding hardness, and the plating solution can be recycled indefinitely without pollution. At the same time, it can also be used as a reducing agent to reduce other substances. At present, dozens of tons of equipment are produced in China.

At present, the amine borane complex that has been used to synthesize pharmaceutical intermediates is N, N- diethylaniline borane complex. When preparing some pharmaceutical intermediates, it shows good chemical selectivity and optical isomerization selectivity. Vientiane enterprises provide N, N- diethylaniline borane complex and its production and supply. In addition, as chiral boron reagents, α -pinene borane (IpC2BH) and chlorinated bis (3- pinene) borane (IpC2BCl) have been applied to the synthesis of many new drugs, and the demand for these compounds is increasing.

Borane is a good chiral selective reducing agent for organic chemical synthesis, and the selective reduction of boron organic products is also different. Borane tetrahydrofuran complex, borane dimethyl sulfide complex, borane pyridine complex, catechol borane, pinacol borane, 2- methyl pyridine borane, N, N- diethylaniline borane, triethylborane, diethyl (3- pyridine) borane, etc. It is used as a very important application in the synthesis of new drugs.

The most commonly used chiral reduction catalysts in the synthesis of new drugs are (R)-2- methyl -CBS- oxazole borane, (S)-2- methyl -CBS- oxazole borane and diisopineyl chloroborane. They are widely used, especially in the production of some high value-added drugs at home and abroad, by directly reducing aldehyde groups and ketone groups in drug molecules to alcohols with specific chirality.