1. Is the efficacy of folic acid tablets safe?
Friends who have bought things online know that the number of online pharmacies is quite large, and the quality and style of products in each store are also uneven. It is easy to buy fake drugs if you are not careful. So, is Silian (Folic Acid Tablets) a safe and effective drug for pregnant women? Can I buy it online?
Since listing, Slian brand has been favored by consumers for its strict quality control and reasonable price positioning.
Generally, friends who have bought things online know that there are many online shops, and the quality and style of goods in each shop are also uneven. Especially in online pharmacies, the quality of a large part of drugs sold is not guaranteed, which leads to a large number of consumers being deceived.
Some consumers like to choose Taobao when buying medicines. Shops with good reputation in Taobao generally have four characteristics: First, they are popular; Second, the buyer has a good opinion of the owner; Third, the comprehensive praise rate of the store is relatively high; Finally, the delivery is quick and timely. Sellers who can generally meet these conditions, then such a shop is still relatively trustworthy.
For the general drug selling website, consumers should see whether it has a license issued by the State Drug Administration. Such a website is a regular online pharmacy.
Silian (Folic Acid Tablets) is a safe and effective drug for pregnant women. It is recommended to buy folic acid tablets in regular pharmacies, and the quality is relatively guaranteed.
2. The efficacy of folic acid
1. Normal fetal development (reducing developmental defects)
According to the current research, folic acid deficiency is related to fetal developmental defects, such as neuraltubedefects (NTDs), which are located in the embryo and are the prototype of the brain and spine. Once lacking in the third to fourth week of pregnancy, neural tube development will be abnormal, which may lead to anencephaly or spina bifida.
Spina bifida refers to the hypoplasia of the spine, which can not protect the spinal cord, resulting in premature infant death, hydrocephalus, lower limb paralysis and other complications.
In addition, folic acid intake during pregnancy has also been proved to reduce the incidence of serious diseases such as congenital heart defects, underweight, limb defects, cleft lip and palate, premature delivery and mental retardation.
Therefore, the US Centers for Disease Control and Prevention recommends that pregnant women and pregnant women consume at least 400 micrograms (mcg) of folic acid every day to meet the needs of fetal development.
2. Dementia (cognitive impairment)
With the decline of fertility rate, most developed countries are facing the problem of population aging, which not only increases the medical burden, but also seriously affects the national competitiveness (the elderly population in China currently accounts for about 17% of the total population, and will increase to 30% in 2020).
It is estimated that about 10 to 15% of the elderly suffer from mild cognitive impairment, and about 2% of them will worsen to Alzheimer's disease within one year.
A double-blind controlled study (3 years, 818 middle-aged and elderly people aged 50-70) pointed out that folic acid supplementation (800mcg per day) is helpful to improve cognitive function related indicators, such as memory, information processing speed and sensory motor speed evaluation scores.
Another controlled study (12 months, 152 elderly people with mild cognitive impairment) also pointed out that short-term use of folic acid may help improve cognition, improve memory function and reduce related inflammatory reactions (the increase of inflammatory hormones is significantly related to the decline of cognitive function).
3. cardiovascular diseases
Cardiovascular disease is the number one health killer of adults in many countries. In the United States alone, 65,438+0 people suffer from various forms of cardiovascular diseases. In recent years, it has been pointed out that cardiovascular diseases are actually the result of long-term inflammation of blood vessels, and besides the known LDL low-density cholesterol (bad cholesterol), homocysteine in blood is also one of the main reasons.
Homocysteamine is an amino acid existing in blood, which comes from the by-product of protein decomposition. If it is too high for a long time, it will destroy vascular endothelial cells, leading to vascular inflammation and cholesterol accumulation.
However, the research report from AmericanMedicalAssociation found that the incidence of cardiovascular diseases in people with higher homocysteine concentration is three times that in people with lower homocysteine concentration, and folic acid supplementation can effectively reduce homocysteine concentration and reduce the possibility of cardiovascular diseases.
Another meta-analysis (including 30 randomized controlled studies with 82,334 participants) pointed out that folic acid supplementation helped to reduce the risk of stroke by 65,438+00% and the overall cardiovascular events by 4%. However, due to the great heterogeneity between studies, such as the reduction of baseline folic acid level, patients' own diseases and homocysteine, it was judged that folic acid supplementation had no significant effect (but it was also harmless).
4. Depression
When most people hear about depression, they just think it is a distant disease, but in fact, in this stressful society, the number of people suffering from depression has soared. The World Health Organization (WTO) estimates that before 2020, depression may become the main cause of disability in developed countries, even worse than cancer and heart disease.
According to the research published in Folic Acid Journal, the incidence of depression in people who lack folic acid in their diet will increase by 67% compared with those who take enough folic acid, so taking folic acid has been proved to improve mental health and prevent depression.
5. Incidence of colorectal cancer
According to the survey, colorectal cancer is the most common cancer in China. Eating too little vegetables and fruits, loving red meat, lack of exercise and other unhealthy living habits will increase the risk of cancer.
Because the initial symptoms of colorectal cancer are not obvious, they are often ignored. Once abnormal symptoms are found, most of them are advanced cancer, and the treatment effect is not good. In addition to eating less red meat and more fruits and vegetables to reduce constipation, a large-scale study of hundreds of thousands of people also found that if the diet is rich in folic acid, the incidence of colorectal cancer can be greatly reduced.
A systematic literature review and meta-analysis (including 65,438+00 studies and 4,565,438+07 participants) pointed out that folic acid supplementation may help reduce the risk of colorectal cancer in patients with intestinal inflammation (up to 42%).