For perimenopausal syndrome, natural estrogen can be taken orally to improve symptoms, but it is not recommended to take drugs orally for a long time, otherwise it will easily stimulate the endometrium and cause endometrial hyperplasia or cancer. The ovarian function of perimenopausal women generally declines gradually from the age of 45, which leads to the change of hormones synthesized by ovaries in the body. This is the only way in life and a natural phenomenon and law. Although biomedicine regards menopause as a hormone deficiency, women often doubt whether they have reached menopause. Even when women are emotionally unstable, onlookers often remind women whether menopause has arrived, which makes women feel uneasy. In order to seek medical treatment, medication, health affirmation, contradiction, fear, expectation, understanding, etc. In menopause, the ovary loses its ability to cope with the normal pituitary gland due to aging, and gradually stops the maturation and excretion of follicles. Therefore, the estrogen produced by the ovaries gradually decreases. Estrogen plummets, losing its cardiovascular protective function, becoming a high-risk group of cardiovascular diseases and osteoporosis, and even threatening the quality of life and mortality in the late menopause and the elderly, which is predictable. It affects the central nervous system, causing inattention, decreased memory, increased Alzheimer's disease, and even related to anti-oxidation (aging). In this study, the smoking rate of patients with coronary heart disease is higher than that of the control group, indicating that smoking is one of the risk factors leading to coronary heart disease in perimenopausal women. Smoking can increase the concentration of fibrinogen, promote the increase of catecholamine and lead to platelet aggregation. Studies have confirmed that smoking in perimenopausal period will increase the risk of myocardial infarction. The increase of cholesterol is also the result of the aggravation of coronary heart disease. The relationship between hyperlipidemia and atherosclerosis is a very clear problem. Both exogenous (excessive animal fat intake) and endogenous (increased lipid synthesis and lipid "clearance" disorder) abnormal lipid metabolism can lead to atherosclerosis. Usually, the increase of blood cholesterol and triglyceride in women with bilateral ovariectomy or postmenopausal women should be regarded as a risk factor for increasing the incidence of coronary heart disease. This study also confirms this. The total cholesterol and low density lipoprotein cholesterol in coronary heart disease group were significantly higher than those in control group. The reason for this change in perimenopausal women is the decrease of estrogen, which weakens its effect and leads to abnormal blood lipid metabolism. Diabetes is one of the risk factors of coronary heart disease. The incidence of coronary heart disease in diabetic patients is twice that in non-diabetic patients. According to clinical observation, hypercholesterolemia, arteriosclerosis and diabetes often occur at the same time, which indicates that the sugar and fat metabolism of postmenopausal women (including artificial menopause) will be damaged, and the estrogen level of postmenopausal women will also change greatly, leading to neurohumoral imbalance, which will affect lipid metabolism and easily lead to cardiovascular system diseases.