The latest research report points out that a long-term ketogenic diet will have a negative impact on the body! Benefits within a week: In a study of mice, researchers at Yale University found that a ketogenic diet that provides 99% calories from fat and only 65,438+0% calories from carbohydrates can bring health benefits to the human body in a short period of time, but it will have negative effects after about a week. This result provides early signs of some problems, indicating that ketogenic diet can improve human health by reducing the risk of diabetes and inflammation in a limited time, and they also represent an important first step in clinical testing of this research in humans.
In the Yale University study published in Natural Metabolism on October 20th, 2020/kloc-0, the researchers in this study found that the positive and negative effects of ketogenic diet on human body are related to an immune cell called γδT cell, which can reduce the risk of diabetes and inflammation.
Vishwa Deep Dixit, lead author of Yale Medical College and professor of immunobiology, said that ketogenic diet can deceive people to burn fat. This is because the carbohydrate content in the diet is reduced, and the glucose concentration of the human body is also reduced. Our bodies act as if they are hungry, although it is not. So the body starts burning fat in exchange for the energy it needs, not carbohydrates. On the contrary, this process will produce a chemical called "ketone body" as an alternative fuel for energy. When the body burns ketone body, γδγ-δT cells with tissue protection will expand all over the body.
The positive and negative effects of ketogenic diet on human body are related to an immune cell called γδT cell. Ketones are a kind of compounds that are produced under hunger, fasting or some pathological conditions (such as diabetes), including acetone, acetoacetic acid and β -hydroxybutyric acid, but strictly speaking, β -hydroxybutyric acid is a hydroxy acid, not a ketone. When the body is in the above state, fat mobilization is strengthened, and a large number of fatty acids are absorbed and oxidized by liver cells; At the same time, in order to maintain the stability of blood sugar concentration, it will also promote the regeneration of sugar in the body. (Source/Wikipedia)
Professor Valdemar von Zeditz of comparative medicine and Professor Weiswa Dipper dixit of immunobiology both pointed out that ketogenic diet can reduce the risk of diabetes and inflammation and improve human metabolism. After a week of ketogenic diet, the blood sugar concentration and inflammatory state of mice decreased a lot.
At the same time, the researchers also found that when the human body is hungry rather than actually hungry, fat storage will occur at the same time as fat decomposition. Professor Vishwa Deep Dixit said that when mice continue to eat a ketogenic diet with high fat and low carbohydrate for more than a week, when they can consume more fat than they can burn, they will develop into diabetes and obesity; He also directly pointed out that this is because these mice lost the protective γδT cells in fat. With regard to this research argument, long-term human clinical research is needed to verify the rumors that ketogenic diet is beneficial to health.
Comparative medicine Comparative medicine is a unique subject of experimental medicine, which uses animal models of human and animal diseases in biomedical research. In other words, it involves and makes use of the biological similarities and differences between species, so as to better understand the disease-related mechanism between humans and animals. (Source/Wikipedia)
In addition, Professor Vishwa Deep Dixit said that before implementing or suggesting that this ketogenic diet is beneficial to human body, large-scale clinical trials must be conducted under controllable conditions to understand the mechanism of metabolic and immune benefits or potential harm to overweight and pre-diabetic individuals. With this latest discovery, researchers can now better understand the working principle of continuous ketogenic diet and why ketogenic diet can bring these health benefits to human body in a limited time.
Emily Goldberger, a doctoral student in comparative medicine, said that our findings highlight the interaction between metabolism and immune system, and how they coordinate and maintain functions related to healthy tissues. Finally, Professor Vishwa Deep Dixit also said that healthy eating habits and ideal time will be the theme and direction of future medical research. If ketone bodies can be found to be beneficial to the human body in a short time, who will be willing to go on a diet and control the state of diet forever?
Reference //news.yale, natural metabolism * * *
Editor//David