1. comfort reply: I know it is difficult to be a man now, but everyone will face such difficulties. I believe you can overcome them and live a strong life.
2. Encourage reply: The difficulty is only temporary. As long as you don't give up, you will find a solution and move on.
3. sarcastic reply: the sky will fall and hit people. First, we must suffer from their minds, work hard and starve their flesh. You are not far from the last (difficulty) now.
Please note that you should consider the other person's emotions and feelings when replying, and try to respond with encouraging and positive language to help her maintain confidence and optimism.